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BMC Cancer:早期宫颈癌根治性子宫切除:腹腔镜vs.开腹?

2015-12-22 MedSci译 MedSci原创

研究者检索了PubMed、MEDLINE、EMBASE、the Cochrane Library和BIOSIS数据库上关于早期宫颈癌患者腹腔镜下根治性子宫切除(LRH)和开腹根治性子宫切除(RH)比较的研究,比较了两种不同术式的围手术期结局、肿瘤清除情况、并发症和长期结局。最终纳入了12项比较LRH(n = 754)和RH(n = 785)的研究。分析数据显示,与RH相比,LRH可显著减少术中出血

研究者检索了PubMed、MEDLINE、EMBASE、the Cochrane Library和BIOSIS数据库上关于早期宫颈癌患者腹腔镜下根治性子宫切除(LRH)和开腹根治性子宫切除(RH)比较的研究,比较了两种不同术式的围手术期结局、肿瘤清除情况、并发症和长期结局。

最终纳入了12项比较LRH(n = 754)和RH(n = 785)的研究。分析数据显示,与RH相比,LRH可显著减少术中出血量(加权均数差 = -268.4 mL;95 % CI -361.6, -175.1; p < 0.01),术后并发症也会更少(OR = 0.46; 95 % CI 0.34-0.63) ,住院时间也更短(加权均数差 = -3.22 天; 95 % CI-4.21, -2.23 days; p < 0.01),但手术时间更长 (加权均数差 = 26.9 分钟;95 % CI 8.08-45.82)。两组术中并发症发生率差异不大,切除淋巴结和切缘肿瘤阳性率在两组间差异也不大,除此之外,5年整体生存(HR 0.91, 95 % CI 0.48-1.71; p = 0.76)和5年无病生存仍无差异(HR 0.97, 95 % CI 0.56-1.68; p = 0.91)。

研究表明,早期宫颈癌患者LRH与RH相比有更好的短期结局,5年生存在两组间相似。

原始出处:

Wang YZ, Deng L,et al.Laparoscopy versus laparotomy for the management of early stage cervical cancer.BMC Cancer. 2015 Nov 24;15:928.

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    2015-12-24 一闲
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