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Neurology:瑞典多发性硬化患者死亡率变化趋势——1968-2012

2017-07-10 zhangfan MedSci原创

研究表明,在近半个世纪的时间,随着医疗水平的进步,多发性硬化患者的生存率以及时间已取得了显著的进步

研究人员对于瑞典多发性硬化(MS)的患者的死亡率以及死因的变化趋势进行了研究。

研究人员考察了1964-2012年间瑞典多发性硬化患者数据。在本次研究中,每一名多发性硬化患者(n = 29617)依据性别、年龄、疾病阶段以及确诊时间匹配10名非多发性硬化参与者(n = 296164)。利用Cox比例风险模型来评估MS患者的死亡风险。

研究发现,在整个研究期间多发性硬化患者的全因死亡风险为2.92(95%,CI,2.86-2.99),其中相对于非MS人群,MS患者死于呼吸系统疾病(HR 5.07, 95% CI 4.87-5.26)以及感染(HR 4.07, 95% CI 3.70-4.47)的风险差异较大。MS患者总体以及各疾病的死亡风险在研究期间呈现出下降趋势,1968-1980年间为6.52 (95% CI 5.79-7.34),2001-2012年间为2.08 (95% CI 1.95-2.22)。

研究表明,在近半个世纪的时间,随着医疗水平的进步,多发性硬化患者的生存率以及时间已取得了显著的进步。

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    2018-06-24 yinhl1978
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    2018-05-14 jml2009
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    2017-07-10 139****5926

    好好文章学习了

    0

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    2017-07-10 执着追梦

    学习,谢谢分享

    0

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    2017-07-10 flysky120

    多发性硬化性

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