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Nat Commun：华东师大发现糖尿病人伤口难愈合新机制

2016-11-26 黄辛 中国科学报

糖尿病
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华东师范大学生命科学院赖玉平课题组揭示了糖尿病伤口难愈合的新机制，为糖尿病伤口愈合的临床治疗提供了新靶点和新方法。相关成果日前在线发表于《自然—通讯》杂志。糖尿病伤口不愈合（糖尿病足）是糖尿病患者的主要并发症之一，会导致患者面临截肢危险。2012年，赖玉平课题组在《免疫学》杂志上发文，报导了胰再生源蛋白REG3A/RegIIIγ可通过诱导角质形成细胞的增殖促进皮肤伤口愈合。4年后，该课题组的进一步

华东师范大学生命科学院赖玉平课题组揭示了糖尿病伤口难愈合的新机制，为糖尿病伤口愈合的临床治疗提供了新靶点和新方法。相关成果日前在线发表于《自然—通讯》杂志。

糖尿病伤口不愈合（糖尿病足）是糖尿病患者的主要并发症之一，会导致患者面临截肢危险。2012年，赖玉平课题组在《免疫学》杂志上发文，报导了胰再生源蛋白REG3A/RegIIIγ可通过诱导角质形成细胞的增殖促进皮肤伤口愈合。

4年后，该课题组的进一步研究表明，胰再生源蛋白REG3A/RegIIIγ在糖尿病病人及糖病小鼠皮肤伤口中低表达，导致糖尿病伤口的过度炎症反应，最终导致糖尿病伤口难愈合。

该项研究表明，糖尿病伤口的过度炎症反应依赖于TLR3信号通路，而胰再生源蛋白REG3A/RegIIIγ通过诱导负调节子SHP-1的表达，抑制糖尿病伤口中TLR3诱导的炎症反应。因此，在糖尿病皮肤伤口中，高血糖抑制REG3A/RegIIIγ的表达，使其不能控制TLR3诱导的炎症反应，从而使糖尿病伤口持续产生过度的炎症因子，导致伤口不能愈合。


原始出处

Yelin Wu, Yanchun Quan, Yuanqi Liu, Keiwei Liu, Hongquan Li, Ziwei Jiang, Tian Zhang, Hu Lei, Katherine A. Radek, Dongqing Li, Zhenhua Wang, Jilong Lu, Wang Wang, Shizhao Ji, Zhaofan Xia & Yuping Lai.Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes.Nat Commun.2016

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    2017-06-12 zhaohui6731

    #难愈合#

    0

  2. 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    2017-05-26 liye789132251

    #Nat#

    0

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    2017-07-24 liuli5079

    #COMMUN#

    0

  4. 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likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Sun Nov 27 09:05:57 CST 2016, time=2016-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158354, encodeId=86ba15835422, content=好想法！, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=34c01688919, createdName=1de520fem71(暂无匿称), createdTime=Sat Nov 26 19:49:59 CST 2016, time=2016-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158345, encodeId=ea1515834567, content=希望能造福临床, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00ac1544010, createdName=mendydong, createdTime=Sat Nov 26 19:04:01 CST 2016, time=2016-11-26, status=1, ipAttribution=)]
    2016-12-06 脱因不花

    胰再生源蛋白REG3A/RegIIIγ在糖尿病病人及糖病小鼠皮肤伤口中低表达，导致糖尿病伤口的过度炎症反应，最终导致糖尿病伤口难愈合。

    0

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    2016-11-29 博雷

    医学在进步，泪崩

    0

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    2016-11-27 jihuaijun1112

    厉害！！！

    0

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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00ac1544010, createdName=mendydong, createdTime=Sat Nov 26 19:04:01 CST 2016, time=2016-11-26, status=1, ipAttribution=)]
    2016-11-27 虈亣靌

    讲的好，学习了

    0

  8. 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likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Sun Nov 27 09:05:57 CST 2016, time=2016-11-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158354, encodeId=86ba15835422, content=好想法！, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=34c01688919, createdName=1de520fem71(暂无匿称), createdTime=Sat Nov 26 19:49:59 CST 2016, time=2016-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=158345, encodeId=ea1515834567, content=希望能造福临床, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00ac1544010, createdName=mendydong, createdTime=Sat Nov 26 19:04:01 CST 2016, time=2016-11-26, status=1, ipAttribution=)]
    2016-11-27 医路开来

    学习啦，谢谢分享

    0

  9. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00ac1544010, createdName=mendydong, createdTime=Sat Nov 26 19:04:01 CST 2016, time=2016-11-26, status=1, ipAttribution=)]
    2016-11-26 1de520fem71(暂无匿称)

    好想法！

    0

  10. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00ac1544010, createdName=mendydong, createdTime=Sat Nov 26 19:04:01 CST 2016, time=2016-11-26, status=1, ipAttribution=)]
    2016-11-26 mendydong

    希望能造福临床

    0

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2016年10月，美国心脏协会(AHA)发布了关于慢性心衰合并高血压，肥胖，糖尿病，高脂血症和代谢综合征的管理以及分摊风险的科学声明。高血压，糖尿病，肥胖，高脂血症和代谢综合征是心衰患者常见的合并症并且影响临床结局。本文的主要目的是总结了分摊风险的相关数据并对心衰患者合并高血压，肥胖，糖尿病，高脂血症和代谢综合征的管理提供指导。全文获取：下载地址：指南下载 (需要扣积分2分, 

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