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Cardiovasc Diabetol:空腹血糖变异性越高,心血管疾病风险越高!

2021-10-17 Nebula MedSci原创

空腹血糖变异性越高,心血管疾病风险越高!关注空腹血糖变异性或可指导临床实践以减低 CVD 的终生风险。

血管疾病 (CVD) 是世界范围内的主要死因,给医疗保健和社会经济带来沉重的负担。识别和管理 CVD 的危险因素对于实现 CVD 的一级预防是必要的。

糖代谢失调是心血管疾病的一项重要危险因素。既往研究表明,较高的空腹血糖 (FBG) 变异性与心血管疾病 (CVD) 之间存在不良关联。终生风险提供个人余生中的绝对风险评估。但是,空腹血糖变异性与心血管疾病终生风险之间的相关性尚未完全明确。

该研究旨在调查随诊空腹血糖变异性对 CVD 终生风险的影响。

纳入了来自 Kailuan 研究的受试者,这些受试者在索引年纪35、45和55岁时没有 CVD。空腹血糖变异性定义为在 2006-2007、2008-2009 和 2010-2011 年检查期间检测的三个空腹血糖值的变异系数 (CV)。采使用改进的 Kaplan-Merrier 方法根据空腹血糖变异性的三分位数估计 CVD 的终生风险。

索引年纪35岁时,空腹血糖变异性低、中、高三组受试者的CVD风险

在索引年纪35岁时,研究样本包含46018位受试者。在中位随访7.0年里,1889位受试者发生了 CVD 事件。在索引35岁时,与空腹血糖变异性低和中等的受试者相比,空腹血糖变异性最高的受试者发生 CVD 事件的风险最高(26.3% vs 28.3% vs 32.5%)。研究人员还发现高空腹血糖变异性于男性的终生 CVD 事件风险升高相关,但在女性中无此相关性。在索引年纪45和55岁时观察到相似的模式。

索引年纪45和55岁时,空腹血糖变异性低、中、高三组受试者的CVD风险

综上所述,高空腹血糖变异性与每个索引年纪受试者的终生 CVD 风险升高相关。关注空腹血糖变异性或可指导临床实践以减低 CVD 的终生风险

原始出处:

Bi, J., Song, L., Wang, L. et al. Visit-to-visit fasting blood glucose variability and lifetime risk of cardiovascular disease: a prospective study. Cardiovasc Diabetol 20, 207 (2021). https://doi.org/10.1186/s12933-021-01397-1

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    2022-03-26 quxin068
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    2021-10-17 马永芳

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