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Hepatology:酒精在丙型肝炎感染患者肝纤维化中的作用

2020-05-11 MedSci原创 MedSci原创

丙型肝炎病毒(HCV)和饮酒是加速肝纤维化进程的风险因素,但很少有随机对照试验对基于临床的饮酒干预措施进行相关研究。本项研究旨在探究酒精在丙型肝炎感染患者肝纤维化中的作用。

背景和目标: 丙型肝炎病毒(HCV)和饮酒是加速肝纤维化进程的风险因素,但很少有随机对照试验对基于临床的饮酒干预措施进行相关研究。本项研究旨在探究酒精在丙型肝炎感染患者肝纤维化中的作用。

方法: 研究人员收集了总共181例在三个肝中心的HCV患者,所有患者被随机分配到以下分组:(1)接受酒精治疗(SBIRT),或(2)SBIRT加上6个月的综合托管酒精疗法(SBIRT +酒精治疗)。时间线跟踪方法用于评估基线,3、6和12个月的饮酒情况。主要的结果是戒酒6个月和大量饮酒6到12个月后肝纤维程度。次要结果包括6个月时每周消耗的酒精克数。

结果: 对于SBIRT仅六个月的患者,六个月的平均治疗时间为8.8月,对于SBIRT +酒精治疗参与者为10.1月。(P= 0.70)。两组中有大量饮酒天的参与者的比例在6个月时均下降,但仅使用SBIRT(87.5%至26.7%)和使用SBIRT +酒精治疗(85.7%至42.1%)的两组之间无显着差异(P= 0.30) 。尽管两个小组将每周平均饮酒克数从基线开始明显减少,但治疗之间的影响并不显着。

结论: 当前或先前HCV感染的患者将接受酒精治疗可以延缓肝的纤维化程度。

原始出处:

Myung Ji Goh. Et al. Statin Use and the Risk of Hepatocellular Carcinoma in Patients With Chronic Hepatitis B. Hepatology.2020.

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    2020-05-13 gwc384

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