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Diabetes Care:Takotsubo综合征患者糖尿病的患病率和预后影响!

2018-02-16 xing.T MedSci原创

由此可见,TTS患者中糖尿病并不常见,它与长期死亡率增加有关,并且与其他危险因素无关,是预后不良的独立预测因子。

糖化血红蛋白(A1C)用于评估择期手术患者,因为高血糖增加了不良事件的发生风险。然而,A1C、葡萄糖与手术治疗的效果之间的相互作用尚不清楚,这三个因素常常只是同时考虑两个。研究人员评估了术前A1C与围手术期血糖控制之间的关系,及其与30天死亡率之间的相关性。

在低患病率来看,糖尿病认为是Takotsubo综合征(TTS)发生的保护因素。此外,在一个小的单中心分析它与结局改善有关。近日,糖尿病领域权威杂志Diabetes Care上发表了研究文章,该研究旨在评估了合并糖尿病的TTS患病率和预后相关性。

该研究共计纳入了826名TTS患者,这些患者参与了一项国际多中心注册研究(意大利和德国八个中心)。研究人员比较糖尿病患者和无糖尿病患者的全因死亡率,并用多元回归分析评价了糖尿病患者的独立预测值。

糖尿病患病率为21.1%(n=174)。TTS的糖尿病患者多为老年人(P<0.001),男性患者更为频繁(P=0.003),高血压患病率较高(P<0.001),较低的左室射血分数(P=0.008),较高的肺水肿的发生率(P=0.032),并且住院时间更长(P=0.009)。然而,糖尿病患者和无糖尿病患者的28天全因死亡率没有差异(6.4% va. 5.7%;风险比为1.11[95%CI为0.55-2.25];P=0.772)。在超过中位随访2.5年显示糖尿病TTS患者的死亡率显著高于对照组(31.4% vs. 16.5%,P<0.001),多元回归分析表明糖尿病是不良预后的独立预测因子(风险比为1.66(95%CI为1.16-2.39),P=0.006)。

由此可见,TTS患者中糖尿病并不常见,它与长期死亡率增加有关,并且与其他危险因素无关,是预后不良的独立预测因子。

原始出处:

Thomas Stiermaier,Prevalence and Prognostic Impact of Diabetes in Takotsubo Syndrome: Insights From the International, Multicenter GEIST Registry.Diabetes Care 2018. https://doi.org/10.2337/dc17-2609

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    2018-02-19 惠映实验室

    学习.谢谢分享.

    0

  5. 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createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDcVAydhtcpjiaxLrZD7Eb5YnKPgf7ypGpfyl7FflFyAenvQLbib6T0LPXIhXo9SPNPXYYFFJbEgykztwJ0HQ61I3F9GxIVKWsgQ/0, createdBy=f38d2052407, createdName=周周人, createdTime=Sat Feb 17 08:10:34 CST 2018, time=2018-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=288455, encodeId=740b28845549, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=140, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/30/21f1f0d02514796066d52523c747be51.jpg, createdBy=75a31960463, createdName=zdvfsadb, createdTime=Fri Feb 16 19:45:12 CST 2018, time=2018-02-16, status=1, ipAttribution=)]
    2018-02-18 清风拂面

    谢谢分享学习

    0

  6. 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    2018-02-17 周周人

    学习.

    0

  10. 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