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Lancet Rheumato:低剂量放疗对膝关节和手部骨关节炎无效

2019-12-02 MedSci MedSci原创

低剂量放射治疗对膝关节和手部骨关节炎患者无显著效果

在德国等一些国家,骨关节炎通常采用低剂量放射治疗。在之前的研究中,三个月的小剂量放射治疗对膝关节和手部骨关节炎患者无显著的治疗效果,近日研究人员公布了6个月和12个月的研究结果。

患者为膝关节或手部骨性关节炎患者,在过去30天中至少有15天疼痛评分5分或5分以上,且不符合2011年ACR纤维肌痛改良标准,随机接受低剂量放射治疗(2周内1Gy低剂量放射治疗,分6次进行)或模拟治疗干预。患者在基线和开始治疗后1、2、3、6和12个月完成问卷调查。研究的主要结局是按照《风湿病学骨关节炎研究学会国际应答者标准》,对治疗有反应的受试者比例。

55名膝关节炎患者参与研究,随机分为低剂量辐射治疗组(n=27)或对照组(n=28)。56名手骨关节炎患者参与研究,随机分为低剂量辐射组(n=28)或对照组(n=28)。研究人员发现在6个月或12个月时,两组对治疗有反应的参与者比例没有显著差异。在膝骨关节炎组,在6个月时,接受低剂量放射治疗的22名患者中有9名(41%)有反应,而对照组26名患者中有9名(35%)有反应(比值比[OR]1.34);在12个月时,25名患者中有13名(52%)有反应vs25名患者中有11名(44%)有反应(OR:1.41)。在手骨关节炎组,在6个月时,接受低剂量放射治疗的25名患者中有7名(28%) vs对照组27名患者中有11名(31%)有反应(OR:0.57);在12个月时,26名患者中有8名(31%) vs26名患者中有7名(27%;OR:1.23)。

研究认为,低剂量放射治疗对膝关节和手部骨关节炎患者无显著效果。

原始出处:


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    2020-04-05 howi
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    2019-12-04 lmm397
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    2020-11-03 lisa438

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