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Nat Commun:基于钼的纳米晶簇能够作为抗氧化物减轻急性肾脏损伤

2018-12-31 AlexYang MedSci原创

急性肾损伤(AKI)是一种常见的与活性氧(ROS)相关的肾脏疾病,每年都能够引起巨大的死亡人数,然而,该疾病的支持性治疗只有在诊所中才可以进行。能够具有在肾脏中高速积累的抗氧化物的开发是迫切需要的,从而来帮助组织AKI。最近,有研究人员报道了基于钼的多金属氧酸盐(POM)纳米晶簇且肾脏优势吸收作为一种新的保护肾脏的纳米抗氧化药物。这些POM纳米晶簇含有钼离子不稳定的可变的价态,具有清除有害的ROS

急性肾损伤(AKI)是一种常见的与活性氧(ROS)相关的肾脏疾病,每年都能够引起巨大的死亡人数,然而,该疾病的支持性治疗只有在诊所中才可以进行。能够具有在肾脏中高速积累的抗氧化物的开发是迫切需要的,从而来帮助阻止AKI。

最近,有研究人员报道了基于钼的多金属氧酸盐(POM)纳米晶簇且肾脏优势吸收作为一种新的保护肾脏的纳米抗氧化药物。这些POM纳米晶簇含有钼离子不稳定的可变的价态,具有清除有害的ROS的能力。他们的结果阐释了POM纳米晶簇能够有效减轻AKI在小鼠中的临床症状,并且与肾脏中动态PET成像、血清测试、肾脏组织染色和生物标记检测结果一致。

最后,研究人员指出,POM纳米晶簇对活体动物AKI的治疗性作用表明了POM纳米晶簇在AKI患者治疗中是有应用价值的,同时也包括了其他ROS相关的疾病。

原始出处:

Dalong Ni, Dawei Jiang, Christopher J. Kutyreff et al. Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice. Nat Commun. 21 Dec 2018.

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    2019-09-03 liye789132251
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    2019-07-18 liuli5079
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A1M Pharma宣布,该公司的候选药物ROSgard在美国与印第安纳大学合作进行的临床前研究中显示出对急性肾损伤(AKI)的强大保护作用。该公司为ROSgard在急性肾损伤领域的持续发展奠定了越来越坚实的基础。I期研究计划于2018年晚些时候开始,主要目的是评估候选药物的安全性。

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