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Am J Geriatr Psychiatry：脑血管风险与老年精神病患者的重度抑郁有关

2015-12-30 徐媛 MedSci原创

抑郁精神病
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本研究旨在研究老年患者的脑血管风险、执行能力和处理速度与精神病性抑郁症的急性治疗结果是否有关。 研究人员纳入了142名具有精神病特征的重度抑郁老年患者，年龄在60岁以上,并将患者随机分配至奥氮平+舍曲林组和奥氮平+安慰剂组，进行一项为期12周的随机对照试验(RCT)。研究中的独立变量是基线脑血管风险(Framingham卒中风险评分)、基线执行能力(Stroop干扰评分和Mattis痴呆评定量表

本研究旨在研究老年患者的脑血管风险、执行能力和处理速度与精神病性抑郁症的急性治疗结果是否有关。

研究人员纳入了142名具有精神病特征的重度抑郁老年患者，年龄在60岁以上,并将患者随机分配至奥氮平+舍曲林组和奥氮平+安慰剂组，进行一项为期12周的随机对照试验(RCT)。研究中的独立变量是基线脑血管风险(Framingham卒中风险评分)、基线执行能力(Stroop干扰评分和Mattis痴呆评定量表的起始/持续分量表)以及基线处理速度(Stroop的颜色和单词阅读部分)。结果变量是抑郁程度的变化，在研究过程中通过17项Hamilton抑郁量表总分进行评估。

随着时间的推移，在控制了相关协变量之后，若抑郁的严重程度得不到较好的改善，则会明显增加基线脑血管病的风险。执行能力和处理速度不能预测结果。

这项研究表明脑血管风险与老年精神病患者的重度抑郁有关，但与执行能力和处理速度不能预测结果。

原始出处

Bingham KS1, Whyte EM2, Meyers BS3, Mulsant BH4, Rothschild AJ5, Banerjee S6, Flint AJ7; STOP-PD Study Group.Relationship Between Cerebrovascular Risk, Cognition, and Treatment Outcome in Late-Life Psychotic Depression.Am J Geriatr Psychiatry. 2015 Dec;

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    2016-10-23 ms5353107019656438

    #血管风险#

    0

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    2016-03-14 12498c32m68暂无昵称

    #GER#

    0

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    2016-06-17 neizongke

    #精神病患者#

    0

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    2016-03-19 diushouji

    #Psychiatry#

    0

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    2016-01-05 小玉6951

    以前没做碰见过这一类的研究，好棒

    0

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