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World J Gastroenterology:为期两天的灌肠抗生素治疗可根除寄生虫感染并缓解症

2020-09-20 MedSci原创 MedSci原创

甲硝唑作为口服的抗生素于1962年首次被用于滴虫病的治疗,在一项研究用甲硝唑或四环素治疗D. fragilis的研究中,在60%的患者中观察到了治疗反应。

        两种厌氧原生动物,人双歧杆菌Blastocystis hominis(B. hominis)和脆弱性衣原体Dientamoeba fragilis(D. fragilis)被认为是“被忽视的寄生虫”,它们在人的肠道中普遍存在。在许多低收入国家,贫困和卫生条件差是造成传染的主要原因。两种寄生虫通常通过粪便-口腔接触或水/食物污染传播,出现的胃肠道症状与肠易激综合症(IBS)和炎症性肠病(IBD)的症状相似。甲硝唑作为口服的抗生素于1962年首次被用于滴虫病的治疗,在一项研究用甲硝唑或四环素治疗D. fragilis的研究中,在60%的患者中观察到了治疗反应,在仅用甲硝唑治疗的患者中有30%的患者症状缓解,而四环素则无效果。因此,本项研究旨在探究使用灌肠输液的三联抗生素疗法在人双歧杆菌和脆弱性衣原体感染中的治疗效果。

 

 

        这是一项回顾性纵向研究,对人双歧杆菌和脆弱性衣原体感染阳性的54名患者(≥18岁)进行连续两天的通过直肠灌肠三联抗生素治疗。从参与者的治疗前后收集粪便样品,并使用显微镜和聚合酶链反应检测其寄生虫。在治疗前后记录患者的症状以及患者的人口统计数据。

 

 

        所有患者均为人双歧杆菌(37%)感染或脆弱弧菌阳性(35%)感染或两者(28%)都感染病例。所有患者均完成了为期两天的治疗,未报告严重不良反应。患者在治疗期间经历的最常见的副作用是尿液变色。治疗前报告的常见症状为腹泻,腹痛,便秘和疲劳。其他症状包括腹部不适,头晕和便血。89%的患者在治疗后完成了最终的粪便测试。治疗后六周,有79%的患者从粪便中清除了寄生虫。治疗后7天和6周,腹部不适,头昏眼花和便血等症状显着降低(P<0.040)。灌肠保留时间,肠道准备,先前的抗生素治疗或先前的胃肠道问题对根除寄生虫没有显着影响。

 

        总体而言,在行为期两天的灌肠抗生素治疗的患者中观察到了寄生虫的根除和临床结果的改善,显示了这治疗方法能根除寄生虫并改善临床结果。

 

原始出处:

Niloufar Roshan. Et al. Two-day enema antibiotic therapy for parasite eradication and resolution of symptoms. World J Gastroenterology.2020.

 

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    2021-02-23 风铃830
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    2021-01-02 Lucky*tian

    👍

    0

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    2021-08-06 许安
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    2020-09-22 zchen
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