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Mayo Clin Proc:ω-3脂肪酸可降低心脏病、高脂血病风险(Meta分析)

2017-01-12 MedSci MedSci原创

一项由一个随机对照试验(RCT)的荟萃分析和另一个前瞻性队列研究的荟萃分析组成的研究表明,美国心脏协会(AHA)关于每天摄入至少1克的二十碳五烯酸(EPA)和二十二碳六烯酸(DHA)来降低冠心病(CHD)事件风险的推荐是合理的。研究结果还表明,那些具有高水平的甘油三酯或低密度脂蛋白胆固醇的患者摄入最佳剂量的ω-3脂肪酸后将获益匪浅。该研究成果发表在今年1月的《梅奥诊所学报》(Mayo Clinic

一项由一个随机对照试验(RCT)的荟萃分析和另一个前瞻性队列研究的荟萃分析组成的研究表明,美国心脏协会(AHA)关于每天摄入至少1克的二十碳五烯酸(EPA)和二十二碳六烯酸(DHA)来降低冠心病(CHD)事件风险的推荐是合理的。

研究结果还表明,那些具有高水平的甘油三酯或低密度脂蛋白胆固醇的患者摄入最佳剂量的ω-3脂肪酸后将获益匪浅。该研究成果发表在今年1月的《梅奥诊所学报》(Mayo Clinic Proceedings)上。

研究人员检索了从1947到2015年11月2日的EPA和DHA的摄入对冠心病事件的影响的相关文献,确定了18个随机对照试验(约93000例)和16项前瞻性队列研究(约732000例)。

通过两个荟萃分析研究人员发现EPA和DHA能减少冠心病的风险,约为6%-18%。

具体而言,在对随机对照试验的荟萃分析中,研究人员发现:与对照组相比,从食物或补充剂中摄入ω-3脂肪酸(EPA / DHA)的实验组的CHD事件风险的降低了无足轻重的6%,心血管事件被定义为心梗、心源性猝死、冠心病死亡、或心绞痛。不过,ω-3脂肪酸的摄入明显与高甘油三酯(> 150mg/dL)或高LDL胆固醇(> 130mg/dL)患者的冠心病风险降低相关。

在对前瞻性队列研究的荟萃分析中,研究人员发现:与ω-3脂肪酸的低摄入量相比,ω-3脂肪酸较高与冠心病风险降低显著相关,降低了18%

然而,这两个荟萃分析有着其固有的局限性(如在设计试验时不一样的措施),同时该研究没有探讨最佳剂量。

最后,研究人员建议:对于普通人群,适度补充ω-3脂肪酸(EPA + DHA,约250mg/天)可能就足够了;而对于更高风险的患者,如那些曾患有心梗和/或高甘油三酯的患者来说,更高的目标不是不合理的。为了更好地了解在这些特定人群中ω-3脂肪酸的潜在好处,未来需要更多的试验来证明。

原始出处:


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    2017-11-22 一闲
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    2017-12-06 guojianrong
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    2017-05-19 linlin2312
  7. [GetPortalCommentsPageByObjectIdResponse(id=1895987, encodeId=1402189598e26, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Wed Nov 22 02:21:00 CST 2017, time=2017-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1822333, encodeId=696618223336d, content=<a href='/topic/show?id=0f551026242e' target=_blank style='color:#2F92EE;'>#高脂血病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102624, encryptionId=0f551026242e, topicName=高脂血病风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2726119, createdName=july_975, createdTime=Wed Jun 07 02:21:00 CST 2017, time=2017-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887590, encodeId=4d95188e590d4, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Wed Dec 06 11:21:00 CST 2017, time=2017-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1778763, encodeId=fb431e78763cb, content=<a href='/topic/show?id=2216130401' target=_blank style='color:#2F92EE;'>#3脂肪酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1304, encryptionId=2216130401, topicName=3脂肪酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Sun Apr 09 09:21:00 CST 2017, time=2017-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779139, encodeId=2b7e1e79139f3, content=<a href='/topic/show?id=2216130401' target=_blank style='color:#2F92EE;'>#3脂肪酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1304, encryptionId=2216130401, topicName=3脂肪酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Thu Jun 15 19:21:00 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1976906, encodeId=004c19e6906b9, content=<a href='/topic/show?id=b9f11560065' target=_blank style='color:#2F92EE;'>#ROC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15600, encryptionId=b9f11560065, topicName=ROC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d590125, createdName=linlin2312, createdTime=Fri May 19 01:21:00 CST 2017, time=2017-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329876, encodeId=80a413298e65a, content=<a href='/topic/show?id=8f3a19290dd' target=_blank style='color:#2F92EE;'>#ω-3脂肪酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19290, encryptionId=8f3a19290dd, topicName=ω-3脂肪酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=232a2500033, createdName=1249859em38(暂无昵称), createdTime=Sat Jan 14 12:21:00 CST 2017, time=2017-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1574576, encodeId=be9715e457627, content=<a href='/topic/show?id=9b56102616bb' target=_blank style='color:#2F92EE;'>#高脂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102616, encryptionId=9b56102616bb, topicName=高脂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c3b716021149, createdName=pcw111, createdTime=Sat Jan 14 12:21:00 CST 2017, time=2017-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601827, encodeId=fe82160182e54, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Sat Jan 14 12:21:00 CST 2017, time=2017-01-14, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1895987, encodeId=1402189598e26, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Wed Nov 22 02:21:00 CST 2017, time=2017-11-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1822333, encodeId=696618223336d, content=<a href='/topic/show?id=0f551026242e' target=_blank style='color:#2F92EE;'>#高脂血病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102624, encryptionId=0f551026242e, topicName=高脂血病风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2726119, createdName=july_975, createdTime=Wed Jun 07 02:21:00 CST 2017, time=2017-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887590, encodeId=4d95188e590d4, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Wed Dec 06 11:21:00 CST 2017, time=2017-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1778763, encodeId=fb431e78763cb, content=<a href='/topic/show?id=2216130401' target=_blank style='color:#2F92EE;'>#3脂肪酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1304, encryptionId=2216130401, topicName=3脂肪酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Sun Apr 09 09:21:00 CST 2017, time=2017-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779139, encodeId=2b7e1e79139f3, content=<a href='/topic/show?id=2216130401' target=_blank style='color:#2F92EE;'>#3脂肪酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1304, encryptionId=2216130401, topicName=3脂肪酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Thu Jun 15 19:21:00 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1976906, encodeId=004c19e6906b9, content=<a href='/topic/show?id=b9f11560065' target=_blank style='color:#2F92EE;'>#ROC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15600, encryptionId=b9f11560065, topicName=ROC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d590125, createdName=linlin2312, createdTime=Fri May 19 01:21:00 CST 2017, time=2017-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1329876, encodeId=80a413298e65a, content=<a href='/topic/show?id=8f3a19290dd' target=_blank style='color:#2F92EE;'>#ω-3脂肪酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19290, encryptionId=8f3a19290dd, topicName=ω-3脂肪酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=232a2500033, createdName=1249859em38(暂无昵称), createdTime=Sat Jan 14 12:21:00 CST 2017, time=2017-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1574576, encodeId=be9715e457627, content=<a href='/topic/show?id=9b56102616bb' target=_blank style='color:#2F92EE;'>#高脂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102616, encryptionId=9b56102616bb, topicName=高脂)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c3b716021149, createdName=pcw111, createdTime=Sat Jan 14 12:21:00 CST 2017, time=2017-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601827, encodeId=fe82160182e54, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Sat Jan 14 12:21:00 CST 2017, time=2017-01-14, status=1, ipAttribution=)]
    2017-01-14 pcw111
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    2017-01-14 sunylz

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根据呈现在IDWeek 2016的研究数据,对于感染HIV、稳定ART的患者,每日高剂量ω-3脂肪酸,与安慰剂相比,可降低患者的甘油三酯和C-反应蛋白水平。塔夫斯大学医学中心的Gretchen Volpe博士说,心血管疾病在艾滋病病毒感染者中普遍存在。“艾滋病毒通过多种途径增加心血管疾病,包括血脂异常、慢性炎症和血管功能障碍,”她在这里的一个演讲中说。Volpe及其同事进行了她所说的最长的随机对照

JAMA Intern Med:补充鱼油能降低致命性冠心病风险

近期有荟萃分析结果表明,植物性和海鲜性ω-3脂肪酸的生物标志物浓度与致命性冠心病(CHD)风险的降低有关。斯坦福大学医学院的博士后研究人员Liana C. Del Gobbo对来自16个国家涉及45637名参与者的19项研究进行了荟萃分析。其中前瞻性队列研究有10项,前瞻性嵌套病例对照研究有7项,回顾性病例对照研究有2项。这些研究中的生物标志物类型的测定包括磷脂(血浆或红细胞,N = 10)、总血

盘点:ω-3脂肪酸这么多好处,你不知道怪我咯

ω-3脂肪酸是机体的必须脂肪酸,可对机体产生多种健康益处。但是人体并不能合成ω-3脂肪酸,需要从食物中获得。ω-3脂肪酸共有11种类型,其中最重要的3种分别是ALA(α-亚麻酸)、EPA(二十碳五烯酸)和DHA(二十二碳六烯酸)。下面小编和大家一起学习ω-3脂肪酸对健康的诸多益处。 1-JAMA Intern Med:补充鱼油能降低致命性冠心病风险 斯坦福大学医学院的研究人员对45

Diabetes Care:ω-3脂肪酸对于高心血管风险成人预后没有作用

ORIGIN试验报告成甘精胰岛素对于高心血管风险的血糖代谢障碍成人进行6.2年的积极治疗对心血管结果,癌症以及减少糖尿病的发生有中性影响。ω-3脂肪酸对心血管预后有中性影响。ORIGIN和ORIGINALE研究检测了这些干预措施在附加的2.7年中的试验后影响。幸存的ORIGIN参与者参加了两个额外的研究。从随机化开始的整个随访期的临床结果风险进行了计算。在12,537名随机化参与者中,试验后数据分

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