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EASL 2014:3D-MRE可准确诊断NASH及晚期肝硬化

2014-04-14 佚名 dxy

与二维磁共振弹性成像技术(2D-MRE)相比,三维磁共振弹性成像(3D-MRE)做为一种评估肝脏硬度的新方法更加地可靠。 为了验证三维磁共振弹性成像诊断非酒精性脂肪性肝炎(NASH)和晚期肝硬化的准确性,来自加州大学圣地亚哥分校的Loomba教授进行了一项前瞻性队列研究。 研究包括了80名(54%为女性)经过活检证实为非酒精性脂肪性肝病(NAFLD)的患者。通过受试者工作特征曲线下面积(AUROC

与二维磁共振弹性成像技术(2D-MRE)相比,三维磁共振弹性成像(3D-MRE)做为一种评估肝脏硬度的新方法更加地可靠。

为了验证三维磁共振弹性成像诊断非酒精性脂肪性肝炎(NASH)和晚期肝硬化的准确性,来自加州大学圣地亚哥分校的Loomba教授进行了一项前瞻性队列研究。

研究包括了80名(54%为女性)经过活检证实为非酒精性脂肪性肝病(NAFLD)的患者。通过受试者工作特征曲线下面积(AUROC )来评估磁共振弹性成像对NASH和晚期肝硬化(分期≥3)的诊断价值。

研究包括NASH和non-NASH患者分别为70和10例。纤维化0、1、2、3、4期的患者分别为33、25、10、6和6例。磁共振弹性成像识别NASH的AUROC为0.852,识别晚期肝硬化的AUROC为0.969。

研究表明,三维磁共振弹性成像能准确地诊断非酒精性脂肪性肝炎及晚期肝硬化。

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    2014-04-16 kksonne
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    2014-04-16 kord1983
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    2014-04-16 lq1771
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    2015-01-10 freve

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长期以来,对于终末期肝病都没有一个较完善的评分指标以评价其严重程度。终末期肝病模型(Model for end-stage liver disease,MELD)标准可对终末期肝病短中期死亡率进行有效的预测,并因其评价指标易得、客观、易于计算,在肝病诊治中广为应用。 然而,MELD分级中使用的血清肌酐、胆红素、INR等指标,容易受非肝病因素的影响,这将直接影响判断真实的肝病病情。对于MELD评分较

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