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Stem cells:维生素C通过DNA羟甲基化促进星形胶质细胞分化

2018-08-03 MedSci MedSci原创

既往研究表明维生素C(VC)可通过DNA羟甲基化诱导多巴胺(DA)神经元特异性基因的转录激活促进神经干/前体细胞(NSC)向DA神经元分化。为进一步明确VC对NSC分化的影响,Jong-Hwan Kim等人采用高通量测序进行转录本和DNA甲基化图谱/羟甲基化图谱分析。研究人员意外的发现RNA测序分析显示,用VC处理分化的NSC培养基中,除了DA神经元基因,星形胶质细胞基因Gfap、Slc1a3和S

既往研究表明维生素C(VC)可通过DNA羟甲基化诱导多巴胺(DA)神经元特异性基因的转录激活促进神经干/前体细胞(NSC)向DA神经元分化。为进一步明确VC对NSC分化的影响,Jong-Hwan Kim等人采用高通量测序进行转录本和DNA甲基化图谱/羟甲基化图谱分析。

研究人员意外的发现RNA测序分析显示,用VC处理分化的NSC培养基中,除了DA神经元基因,星形胶质细胞基因Gfap、Slc1a3和S100a16的表达水平也上调。与上述发现一致,在经VC处理的分化培养基中,GFAP+星形胶质细胞数量增多,提示VC也可促进星形胶质细胞分化。

全基因组羟甲基化分析显示,VC处理可诱导DNA羟甲基化(5羟甲基胞嘧啶;5hmC)在核因子I(NFI)结合模体附近富集。而且,研究人员还发现VC可显着增强星形胶质细胞特异性基因的5hmC富集区域的NFI和STAT3(星形胶质细胞发生的关键转录因子)的招募。

综上所述,本研究表明VC在脑发育过程中的星形胶质细胞发生中发挥重要作用。

原始出处:

Jong-Hwan Kim,et al. Vitamin C Promotes Astrocyte Differentiation Through DNA Hydroxymethylation. Stem cells.July 13,2018.https://doi.org/10.1002/stem.2886

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    2019-06-13 维他命
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  5. 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    2018-08-03 1ddf0692m34(暂无匿称)

    学习了,长知识

    0

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神经元(神经细胞)具有长突起,是构成神经系统结构和功能的基本单位。

Nature Medicine:脊髓损伤后星形胶质细胞瘢痕形成的新机制!

该研究的发现揭示了调节星形细胞命运决定的环境线索,从而为中枢神经系统损伤提供了潜在的治疗靶点。

Stem Cell Reports:科学家利用小分子化合物将成人星形胶质细胞转变为神经细胞

2 月 16 日,《干细胞报道》(Stem Cell Reports)在线发表了中国科学院上海生命科学研究院生物化学与细胞生物学研究所裴钢研究组的研究论文 Direct Generation of Human Neuronal Cells from Adult Astrocytes by Small Molecules,报道了利用小分子化合物组合实现将成人星形胶质细胞直接转变为神经细胞的研究成果。

Autophagy:星形胶质细胞通过KISS1调节自噬促进乳腺癌转移到大脑的进展。

转移灶的形成,是乳腺癌(BrCa)进展中的一个重要阶段。KISS1 的表达与转移进展受到抑制相关。最近,作者的研究表明,BrCa 转移到大脑时在mRNA和蛋白水平都只有低水平的KISS1表达。

Biol Psychiat:发炎的星形胶质细胞也能导致自闭症

加州大学圣地亚哥医学院(University of California San Diego School of Medicine)的研究人员与来自巴西的同事们建立了一个由自闭症谱系障碍儿童(ASD)衍生的神经元与星形胶质细胞之间相互作用的模型,他们说,星形胶质细胞的先天炎症似乎在某种形式的疾病中会导致神经功能障碍。

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