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JCEM:补充合生元和生活方式改变对多囊卵巢综合征妇女的影响

2021-06-13 MedSci原创 MedSci原创

补充合生元对生活方式改变引起的体重减轻具有效应,并导致血清睾酮水平显著减少。

多囊卵巢综合征(PCOS)是影响育龄妇女最常见的内分泌疾病。

近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,该研究旨在评估生活方式改变和补充合生元对PCOS的疗效。

该研究为一项在教学医院进行的随机(1:1)双盲、安慰剂对照试验。研究人员根据鹿特丹标准确定确定了超重和肥胖的PCOS妇女。研究人员在基线时对受试者进行了评估,并在治疗3个月后再次进行评估。该研究的干预为生活方式改变与补充合生元或安慰剂。该研究的主要结局指标为BMI和睾酮水平的变化。

生活方式改变和合生元的效应

在安慰剂组中,体重指数下降5%的同时,腰围、臀部和大腿围也显著减小。合生元组的BMI下降了8%,显著高于对照组(P=0.03),同时腰围、臀围和大腿围也下降了。在安慰剂组睾酮水平没有显著降低(下降了6%),而合生元组睾酮水平下降了32% (P<0.0001)。与安慰剂组相比,合生元组的睾酮水平下降更为显著(P=0.016)。

由此可见,补充合生元对生活方式改变引起的体重减轻具有效应,并导致血清睾酮水平显著减少

原始出处:

Izabela Chudzicka-Strugała.et al.Effects of synbiotic supplementation and lifestyle modifications on women with polycystic ovary syndrome.JCEM.2021.https://doi.org/10.1210/clinem/dgab369

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    2022-03-15 achengzhao
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    2022-03-21 smallant2015
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    2021-06-15 weigq

    0

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    2021-06-15 zt123

    学习了一下

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    2021-06-14 ms9000000883963153

    十分有帮助

    0

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