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JAHA:血液透析患者使用促红细胞生成素治疗与卒中风险

2021-06-27 MedSci原创 MedSci原创

接受血液透析的患者采用促红细胞生成素治疗与卒中或其任何亚型卒中的风险增加无关。

采用促红细胞生成素靶向提高血红蛋白水平来治疗慢性肾病患者的贫血与其血管风险增加相关,包括卒中风险。在接受血液透析的终末期肾病患者中使用促红细胞生成素治疗后,卒中、缺血性卒中、出血性卒中和未明确亚型卒中的风险尚未明确。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,该研究总共纳入了12948名在1999年至2010年期间接受过血液透析的终末期肾病成年患者。该研究的终点是卒中及其亚型的发生率。

研究人员使用Cox比例风险回归模型来估计促红细胞生成素治疗者与非治疗者相比卒中及其亚型的风险比 (HR)。

比值比分析结果

与非促红细胞生成素使用者相比,促红细胞生成素使用者的卒中风险并未增加(调整后的HR为1.03;95%CI为0.92–1.15)。与非促红细胞生成素治疗者相比,促红细胞生成素治疗者发生缺血性、出血性或未明确亚型卒中风险并未升高(调整后的HR为1.08 [95%CI为0.93-1.26]、0.96 [95%CI为0.78-1.18]和1.03[95%CI为0.80–1.32])。

由此可见,接受血液透析的患者采用促红细胞生成素治疗与卒中或其任何亚型卒中的风险增加无关

原始出处:

Peir‐Haur Hung.et al.Erythropoietin Use and the Risk of Stroke in Patients on Hemodialysis: A Retrospective Cohort Study in Taiwan.J AM HEART ASSOC.2021.https://www.ahajournals.org/doi/full/10.1161/JAHA.120.019529

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    2021-07-15 ms8000000839225845

    学习了

    0

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  4. 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  5. 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topicList=[TopicDto(id=94835, encryptionId=e53d94835a5, topicName=透析患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4b0915676167, createdName=ewsr6, createdTime=Tue Jun 29 13:57:09 CST 2021, time=2021-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=977600, encodeId=582d9e7600d0, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210628/d028dd72803b466fbec4fbb95fb69ab8/36dc5ab269ac424d983ff54da9dc4e15.jpg, createdBy=37881573320, createdName=liuyingying35, createdTime=Mon Jun 28 15:34:16 CST 2021, time=2021-06-28, status=1, ipAttribution=)]
    2021-06-29 zhaohui6731
  6. 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  7. 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