Baidu
map

Am J Respir Crit Care Med:奥马利珠单抗对阿司匹林加重的呼吸系统疾病的疗效如何?

2020-11-13 MedSci原创 MedSci原创

阿司匹林加重型呼吸道疾病的特点是严重的哮喘、非甾体抗炎药物过敏、鼻息肉病和白三烯过度分泌。系统性皮质激素治疗不能完全抑制终生的阿司匹林超敏反应。目前,尚未有随机试验探究奥马利珠单抗对阿司匹林加重的呼吸

阿司匹林加重型呼吸道疾病的特点是严重的哮喘、非甾体抗炎药物过敏、鼻息肉病和白三烯过度分泌。系统性皮质激素治疗不能完全抑制终生的阿司匹林超敏反应。目前,尚未有随机试验探究奥马利珠单抗对阿司匹林加重的呼吸系统疾病的疗效。本研究旨在评估奥马利珠单抗对阿司匹林过敏、白三烯E4过量产生和阿司匹林加重呼吸道疾病患者口服阿司匹林治疗期间的症状的疗效,研究已在线发表于Am J Respir Crit Care Med
研究人员于2015年8月至2016年12月在相模原国立医院进行了一项双盲、随机、交叉、安慰剂对照的单中心研究。将阿司匹林加重的呼吸系统疾病的特应性患者(20-79岁)随机(1:1)分配,分别接受奥马利珠单抗或安慰剂治疗3个月,然后进行>18周的冲洗期(交叉设计)。主要终点是口服阿司匹林挑战期间,意向治疗人群的尿白三烯E4浓度对数下面积水平与时间曲线的差异。
 
结果,16名患者完成了研究,并纳入分析。口服阿司匹林挑战期间尿白三烯E4浓度与时间曲线的对数下面积水平在奥马珠单抗阶段(中位数[四分位数范围],51.1[44.5-59.8])显著低于安慰剂阶段(80.8[四分位数范围,65.4-87.8])(P <0.001)。10名患者(62.5%)在奥马利珠单抗阶段出现了口服阿司匹林耐受性,最高累计剂量为930mg(P <0.001)。
综上所述,该研究结果表明,奥马利珠单抗治疗抑制了口服阿司匹林治疗过程中尿液白三烯E4的过量产生和上/下呼吸道症状,会使62.5%的阿司匹林加重型呼吸道疾病患者产生阿司匹林耐受。
 
原始出处:
 
Hiroaki Hayashi, Yuma Fukutomi, et al., Omalizumab for Aspirin Hypersensitivity and Leukotriene Overproduction in Aspirin-exacerbated Respiratory Disease. A Randomized Controlled Trial. Am J Respir Crit Care Med. 2020 Jun 15;201(12):1488-1498. doi: 10.1164/rccm.201906-1215OC.
 

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=904250, encodeId=08a290425001, content=这个研究意义比较小吧,对于<a href='/topic/show?id=51639e734cb' target=_blank style='color:#2F92EE;'>#阿司匹林#</a>引发的哮喘,只需要不再使用阿司匹林即可。不过,阿司匹林哮喘的机制值得研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=231, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97734, encryptionId=51639e734cb, topicName=阿司匹林)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=lifefamily@163, createdTime=Wed Dec 02 11:46:26 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419020, encodeId=23a114190208e, content=<a href='/topic/show?id=ab4d3969143' target=_blank style='color:#2F92EE;'>#呼吸系统疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39691, encryptionId=ab4d3969143, topicName=呼吸系统疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=75de3457664, createdName=医生2395, createdTime=Sun Nov 15 13:26:20 CST 2020, time=2020-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610787, encodeId=6cf51610e877b, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Nov 15 13:26:20 CST 2020, time=2020-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032708, encodeId=bab61032e08ca, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Sat Nov 14 01:26:20 CST 2020, time=2020-11-14, status=1, ipAttribution=)]
    2020-12-02 lifefamily@163

    这个研究意义比较小吧,对于#阿司匹林#引发的哮喘,只需要不再使用阿司匹林即可。不过,阿司匹林哮喘的机制值得研究

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=904250, encodeId=08a290425001, content=这个研究意义比较小吧,对于<a href='/topic/show?id=51639e734cb' target=_blank style='color:#2F92EE;'>#阿司匹林#</a>引发的哮喘,只需要不再使用阿司匹林即可。不过,阿司匹林哮喘的机制值得研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=231, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97734, encryptionId=51639e734cb, topicName=阿司匹林)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=lifefamily@163, createdTime=Wed Dec 02 11:46:26 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419020, encodeId=23a114190208e, content=<a href='/topic/show?id=ab4d3969143' target=_blank style='color:#2F92EE;'>#呼吸系统疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39691, encryptionId=ab4d3969143, topicName=呼吸系统疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=75de3457664, createdName=医生2395, createdTime=Sun Nov 15 13:26:20 CST 2020, time=2020-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610787, encodeId=6cf51610e877b, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Nov 15 13:26:20 CST 2020, time=2020-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032708, encodeId=bab61032e08ca, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Sat Nov 14 01:26:20 CST 2020, time=2020-11-14, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=904250, encodeId=08a290425001, content=这个研究意义比较小吧,对于<a href='/topic/show?id=51639e734cb' target=_blank style='color:#2F92EE;'>#阿司匹林#</a>引发的哮喘,只需要不再使用阿司匹林即可。不过,阿司匹林哮喘的机制值得研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=231, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97734, encryptionId=51639e734cb, topicName=阿司匹林)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=lifefamily@163, createdTime=Wed Dec 02 11:46:26 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419020, encodeId=23a114190208e, content=<a href='/topic/show?id=ab4d3969143' target=_blank style='color:#2F92EE;'>#呼吸系统疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39691, encryptionId=ab4d3969143, topicName=呼吸系统疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=75de3457664, createdName=医生2395, createdTime=Sun Nov 15 13:26:20 CST 2020, time=2020-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610787, encodeId=6cf51610e877b, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Nov 15 13:26:20 CST 2020, time=2020-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032708, encodeId=bab61032e08ca, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Sat Nov 14 01:26:20 CST 2020, time=2020-11-14, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=904250, encodeId=08a290425001, content=这个研究意义比较小吧,对于<a href='/topic/show?id=51639e734cb' target=_blank style='color:#2F92EE;'>#阿司匹林#</a>引发的哮喘,只需要不再使用阿司匹林即可。不过,阿司匹林哮喘的机制值得研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=231, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97734, encryptionId=51639e734cb, topicName=阿司匹林)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=lifefamily@163, createdTime=Wed Dec 02 11:46:26 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419020, encodeId=23a114190208e, content=<a href='/topic/show?id=ab4d3969143' target=_blank style='color:#2F92EE;'>#呼吸系统疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39691, encryptionId=ab4d3969143, topicName=呼吸系统疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=75de3457664, createdName=医生2395, createdTime=Sun Nov 15 13:26:20 CST 2020, time=2020-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610787, encodeId=6cf51610e877b, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Nov 15 13:26:20 CST 2020, time=2020-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1032708, encodeId=bab61032e08ca, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Sat Nov 14 01:26:20 CST 2020, time=2020-11-14, status=1, ipAttribution=)]
    2020-11-14 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

相关资讯

J Asthma:奥马珠单抗可改善哮喘的症状

抗免疫球蛋白E单克隆抗体奥马珠单抗用于治疗重症哮喘,具有改善气道炎症的潜力。然而,奥马利珠单抗改善上气道炎症的效果尚未完全阐明。本研究旨在探究上、下气道炎症与奥马珠单抗治疗反应的关系。

Environ Res:吸烟、环境烟草烟雾、室内粉刷和居住在新旧建筑中对哮喘、鼻炎和呼吸道症状影响情况的前瞻性研究

最近,有研究人员对北欧11506名成年人进行了为期10年的跟踪调查,探索了烟草烟雾、家庭环境和呼吸系统健康之间的关系。

赛诺菲的IL-4/IL-13单抗Dupixent显著减轻儿童的严重哮喘发作

Dupixent是是唯一一个在III期临床试验中显著改善儿童肺功能的生物制剂。

Thorax:哮喘患者口服和吸入皮质类固醇导致骨质疏松和脆性骨折的风险

OCS或ICS是哮喘患者骨骼健康的独立危险因素。建议以尽可能低的类固醇激素维持哮喘控制。

哮喘治疗新突破:IL-15Rα单抗FASENRA让62%的患者摆脱口服糖皮质激素

在有史以来规模最大的重度哮喘患者中,62%的患者摆脱了口服糖皮质激素。

阿斯利康的TSLP单抗tezepelumab治疗严重哮喘,III期临床成功

“tezepelumab不同其他哮喘生物药物,是通过阻断胸腺基质淋巴细胞生成素(TSLP)发挥作用。”

Baidu
map
Baidu
map
Baidu
map