Photodiagnosis Photodyn Ther：N-乙酰半胱氨酸防止由光动力治疗引起的脉络膜视网膜损伤

2018-04-26 cuiguizhong MedSci原创

韩国首尔国立大学医学院眼科的Kim TW近日在Photodiagnosis Photodyn Ther发表了他们近期的一项工作，他们在脉络膜新生血管（CNV）大鼠模型中，探讨了N-乙酰半胱氨酸（NAC）对由光动力治疗（PDT）引起的脉络膜视网膜损伤的保护作用。

韩国首尔国立大学医学院眼科的Kim TW近日在Photodiagnosis Photodyn Ther发表了他们近期的一项工作，他们在脉络膜新生血管（CNV）大鼠模型中，探讨了N-乙酰半胱氨酸（NAC）对由光动力治疗（PDT）引起的脉络膜视网膜损伤的保护作用。

在PDT治疗前7天，在24只Brown挪威大鼠中用氩激光诱导实验性CNV造模。从CNV诱导后1天开始，每天对NAC阳性组（12只大鼠）口服0.5mL NAC，并向NAC阴性组（12只大鼠）注射0.5mL生理盐水。在注射维替泊芬（PDT-）之前，在左眼进行42秒（总能量，25J / cm 2）的激光治疗，并且在这种输注（PDT +）之后15-20分钟，对右眼进行相同处理。在PDT和眼球摘除前进行荧光素血管造影以评估荧光素渗漏和CNV闭合情况。通过末端dUTP缺口末端标记（TUNEL）来评估PDT诱导的细胞凋亡情况，比较CNV厚度、荧光素血管造影数据和两组间切割的半胱天冬酶-3和超氧化物歧化酶（SOD）的免疫组织荧光染色的程度。

结果他们发现，激光治疗后14天，PDT治疗组的CNV闭合率显着高于对照组。然而，NAC阴性和NAC阳性组之间的CNV闭合率没有显着差异。在第1、3、7和14天，NAC- / PDT +中的视网膜细胞的TUNEL活性（用来衡量PDT诱导的细胞凋亡程度）高于NAC + / PDT +组。在第3天和第7天，在NAC-/PDT+中裂解的胱天蛋白酶-3和SOD水平比在NAC + / PDT +组中更高。

因此，他们认为，PDT可以引发氧自由基，进而诱导视网膜损伤和细胞凋亡。NAC可减少PDT对视网膜的损伤而不影响CNV的治疗效果。

原文出处：

Kim， T.W.， J.W. Moon， and H.G. Yu， N-acetylcysteine Protects Against Chorioretinal Damage Induced by Photodynamic Therapy for Experimental Choroidal Neovascularization in a Rat Model. Photodiagnosis Photodyn Ther， 2018.

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2018-08-09 wshxjq

#光动力治疗#

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2019-03-04 ms7421025882867189

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2018-09-08 ms9608593228839890

#DIA#

64 0
[GetPortalCommentsPageByObjectIdResponse(id=1719553, encodeId=0b971e195537c, content=<a href='/topic/show?id=404928e34f6' target=_blank style='color:#2F92EE;'>#光动力治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28734, encryptionId=404928e34f6, topicName=光动力治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c432763729, createdName=wshxjq, createdTime=Thu Aug 09 11:40:00 CST 2018, time=2018-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2054924, encodeId=1e8c2054924fe, content=<a href='/topic/show?id=e2365922f4' target=_blank style='color:#2F92EE;'>#diagnosis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5922, encryptionId=e2365922f4, topicName=diagnosis)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3c932500160, createdName=ms7421025882867189, createdTime=Mon Mar 04 00:40:00 CST 2019, time=2019-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638585, encodeId=be7116385854e, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Sep 08 01:40:00 CST 2018, time=2018-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1687016, encodeId=4ecd168e016bb, content=<a href='/topic/show?id=5f688449023' target=_blank style='color:#2F92EE;'>#脉络膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, 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style='color:#2F92EE;'>#photo#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14201, encryptionId=ce4314201f3, topicName=photo)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cb3a261, createdName=liuxiaona, createdTime=Sat Feb 23 18:40:00 CST 2019, time=2019-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1270047, encodeId=fa4112e00479a, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Sat Apr 28 14:40:00 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397526, encodeId=4eff139e526a7, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Sat Apr 28 14:40:00 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546304, encodeId=2fa615463042a, content=<a href='/topic/show?id=0da528e33ce' target=_blank style='color:#2F92EE;'>#光动力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28733, encryptionId=0da528e33ce, topicName=光动力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2b6213920685, createdName=luckyshitiancai_42705688, createdTime=Sat Apr 28 14:40:00 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309738, encodeId=92ff309e3845, content=学习学习.了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Fri Apr 27 08:25:25 CST 2018, time=2018-04-27, status=1, ipAttribution=)]
2018-05-08 12498568m59暂无昵称

#脉络膜#

93 0
[GetPortalCommentsPageByObjectIdResponse(id=1719553, encodeId=0b971e195537c, content=<a href='/topic/show?id=404928e34f6' target=_blank style='color:#2F92EE;'>#光动力治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28734, encryptionId=404928e34f6, topicName=光动力治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c432763729, createdName=wshxjq, createdTime=Thu Aug 09 11:40:00 CST 2018, time=2018-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2054924, encodeId=1e8c2054924fe, content=<a href='/topic/show?id=e2365922f4' target=_blank style='color:#2F92EE;'>#diagnosis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5922, encryptionId=e2365922f4, topicName=diagnosis)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3c932500160, createdName=ms7421025882867189, createdTime=Mon Mar 04 00:40:00 CST 2019, time=2019-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638585, encodeId=be7116385854e, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Sep 08 01:40:00 CST 2018, time=2018-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1687016, encodeId=4ecd168e016bb, content=<a href='/topic/show?id=5f688449023' target=_blank style='color:#2F92EE;'>#脉络膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84490, encryptionId=5f688449023, topicName=脉络膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a15828309522, createdName=12498568m59暂无昵称, createdTime=Tue May 08 22:40:00 CST 2018, time=2018-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1735651, encodeId=c6341e35651e1, content=<a href='/topic/show?id=687923464ae' target=_blank style='color:#2F92EE;'>#乙酰半胱氨酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23464, encryptionId=687923464ae, topicName=乙酰半胱氨酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=859133934050, createdName=yhj-time, createdTime=Wed Dec 19 13:40:00 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788725, encodeId=559c1e8872555, content=<a href='/topic/show?id=ce4314201f3' target=_blank style='color:#2F92EE;'>#photo#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14201, encryptionId=ce4314201f3, topicName=photo)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cb3a261, createdName=liuxiaona, createdTime=Sat Feb 23 18:40:00 CST 2019, time=2019-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1270047, encodeId=fa4112e00479a, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Sat Apr 28 14:40:00 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397526, encodeId=4eff139e526a7, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Sat Apr 28 14:40:00 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546304, encodeId=2fa615463042a, content=<a href='/topic/show?id=0da528e33ce' target=_blank style='color:#2F92EE;'>#光动力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28733, encryptionId=0da528e33ce, topicName=光动力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2b6213920685, createdName=luckyshitiancai_42705688, createdTime=Sat Apr 28 14:40:00 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309738, encodeId=92ff309e3845, content=学习学习.了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Fri Apr 27 08:25:25 CST 2018, time=2018-04-27, status=1, ipAttribution=)]
2018-12-19 yhj-time

#乙酰半胱氨酸#

103 0
[GetPortalCommentsPageByObjectIdResponse(id=1719553, encodeId=0b971e195537c, content=<a href='/topic/show?id=404928e34f6' target=_blank style='color:#2F92EE;'>#光动力治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28734, encryptionId=404928e34f6, topicName=光动力治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c432763729, createdName=wshxjq, createdTime=Thu Aug 09 11:40:00 CST 2018, time=2018-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2054924, encodeId=1e8c2054924fe, content=<a href='/topic/show?id=e2365922f4' target=_blank style='color:#2F92EE;'>#diagnosis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5922, encryptionId=e2365922f4, topicName=diagnosis)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3c932500160, createdName=ms7421025882867189, createdTime=Mon Mar 04 00:40:00 CST 2019, time=2019-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638585, encodeId=be7116385854e, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Sep 08 01:40:00 CST 2018, time=2018-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1687016, encodeId=4ecd168e016bb, content=<a href='/topic/show?id=5f688449023' target=_blank style='color:#2F92EE;'>#脉络膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84490, encryptionId=5f688449023, topicName=脉络膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a15828309522, createdName=12498568m59暂无昵称, createdTime=Tue May 08 22:40:00 CST 2018, time=2018-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1735651, encodeId=c6341e35651e1, content=<a href='/topic/show?id=687923464ae' target=_blank style='color:#2F92EE;'>#乙酰半胱氨酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23464, encryptionId=687923464ae, topicName=乙酰半胱氨酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=859133934050, createdName=yhj-time, createdTime=Wed Dec 19 13:40:00 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788725, encodeId=559c1e8872555, content=<a href='/topic/show?id=ce4314201f3' target=_blank style='color:#2F92EE;'>#photo#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14201, encryptionId=ce4314201f3, topicName=photo)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cb3a261, createdName=liuxiaona, createdTime=Sat Feb 23 18:40:00 CST 2019, time=2019-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1270047, encodeId=fa4112e00479a, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Sat Apr 28 14:40:00 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397526, encodeId=4eff139e526a7, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Sat Apr 28 14:40:00 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546304, encodeId=2fa615463042a, content=<a href='/topic/show?id=0da528e33ce' target=_blank style='color:#2F92EE;'>#光动力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28733, encryptionId=0da528e33ce, topicName=光动力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2b6213920685, createdName=luckyshitiancai_42705688, createdTime=Sat Apr 28 14:40:00 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309738, encodeId=92ff309e3845, content=学习学习.了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Fri Apr 27 08:25:25 CST 2018, time=2018-04-27, status=1, ipAttribution=)]
2019-02-23 liuxiaona

#photo#

84 0
[GetPortalCommentsPageByObjectIdResponse(id=1719553, encodeId=0b971e195537c, content=<a href='/topic/show?id=404928e34f6' target=_blank style='color:#2F92EE;'>#光动力治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28734, encryptionId=404928e34f6, topicName=光动力治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c432763729, createdName=wshxjq, createdTime=Thu Aug 09 11:40:00 CST 2018, time=2018-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2054924, encodeId=1e8c2054924fe, content=<a href='/topic/show?id=e2365922f4' target=_blank style='color:#2F92EE;'>#diagnosis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5922, encryptionId=e2365922f4, topicName=diagnosis)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3c932500160, createdName=ms7421025882867189, createdTime=Mon Mar 04 00:40:00 CST 2019, time=2019-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638585, encodeId=be7116385854e, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Sep 08 01:40:00 CST 2018, time=2018-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1687016, encodeId=4ecd168e016bb, content=<a href='/topic/show?id=5f688449023' target=_blank style='color:#2F92EE;'>#脉络膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84490, encryptionId=5f688449023, topicName=脉络膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a15828309522, createdName=12498568m59暂无昵称, createdTime=Tue May 08 22:40:00 CST 2018, time=2018-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1735651, encodeId=c6341e35651e1, content=<a href='/topic/show?id=687923464ae' target=_blank style='color:#2F92EE;'>#乙酰半胱氨酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23464, encryptionId=687923464ae, topicName=乙酰半胱氨酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=859133934050, createdName=yhj-time, createdTime=Wed Dec 19 13:40:00 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788725, encodeId=559c1e8872555, content=<a href='/topic/show?id=ce4314201f3' target=_blank style='color:#2F92EE;'>#photo#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14201, encryptionId=ce4314201f3, topicName=photo)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cb3a261, createdName=liuxiaona, createdTime=Sat Feb 23 18:40:00 CST 2019, time=2019-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1270047, encodeId=fa4112e00479a, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Sat Apr 28 14:40:00 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397526, encodeId=4eff139e526a7, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Sat Apr 28 14:40:00 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546304, encodeId=2fa615463042a, content=<a href='/topic/show?id=0da528e33ce' target=_blank style='color:#2F92EE;'>#光动力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28733, encryptionId=0da528e33ce, topicName=光动力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2b6213920685, createdName=luckyshitiancai_42705688, createdTime=Sat Apr 28 14:40:00 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309738, encodeId=92ff309e3845, content=学习学习.了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Fri Apr 27 08:25:25 CST 2018, time=2018-04-27, status=1, ipAttribution=)]
2018-04-28 zutt

#视网膜#

69 0
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createdBy=3c932500160, createdName=ms7421025882867189, createdTime=Mon Mar 04 00:40:00 CST 2019, time=2019-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638585, encodeId=be7116385854e, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Sep 08 01:40:00 CST 2018, time=2018-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1687016, encodeId=4ecd168e016bb, content=<a href='/topic/show?id=5f688449023' target=_blank style='color:#2F92EE;'>#脉络膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84490, encryptionId=5f688449023, topicName=脉络膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a15828309522, createdName=12498568m59暂无昵称, createdTime=Tue May 08 22:40:00 CST 2018, time=2018-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1735651, encodeId=c6341e35651e1, content=<a href='/topic/show?id=687923464ae' target=_blank style='color:#2F92EE;'>#乙酰半胱氨酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23464, encryptionId=687923464ae, topicName=乙酰半胱氨酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=859133934050, createdName=yhj-time, createdTime=Wed Dec 19 13:40:00 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788725, encodeId=559c1e8872555, content=<a href='/topic/show?id=ce4314201f3' target=_blank style='color:#2F92EE;'>#photo#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14201, encryptionId=ce4314201f3, topicName=photo)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cb3a261, createdName=liuxiaona, createdTime=Sat Feb 23 18:40:00 CST 2019, time=2019-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1270047, encodeId=fa4112e00479a, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Sat Apr 28 14:40:00 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397526, encodeId=4eff139e526a7, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Sat Apr 28 14:40:00 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546304, encodeId=2fa615463042a, content=<a href='/topic/show?id=0da528e33ce' target=_blank style='color:#2F92EE;'>#光动力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28733, encryptionId=0da528e33ce, topicName=光动力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2b6213920685, createdName=luckyshitiancai_42705688, createdTime=Sat Apr 28 14:40:00 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309738, encodeId=92ff309e3845, content=学习学习.了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Fri Apr 27 08:25:25 CST 2018, time=2018-04-27, status=1, ipAttribution=)]
2018-04-28 ms3046638856685384

#损伤#

62 0
[GetPortalCommentsPageByObjectIdResponse(id=1719553, encodeId=0b971e195537c, content=<a href='/topic/show?id=404928e34f6' target=_blank style='color:#2F92EE;'>#光动力治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28734, encryptionId=404928e34f6, topicName=光动力治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c432763729, createdName=wshxjq, createdTime=Thu Aug 09 11:40:00 CST 2018, time=2018-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2054924, encodeId=1e8c2054924fe, content=<a href='/topic/show?id=e2365922f4' target=_blank style='color:#2F92EE;'>#diagnosis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5922, encryptionId=e2365922f4, topicName=diagnosis)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3c932500160, createdName=ms7421025882867189, createdTime=Mon Mar 04 00:40:00 CST 2019, time=2019-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638585, encodeId=be7116385854e, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Sep 08 01:40:00 CST 2018, time=2018-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1687016, encodeId=4ecd168e016bb, content=<a href='/topic/show?id=5f688449023' target=_blank style='color:#2F92EE;'>#脉络膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84490, encryptionId=5f688449023, topicName=脉络膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a15828309522, createdName=12498568m59暂无昵称, createdTime=Tue May 08 22:40:00 CST 2018, time=2018-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1735651, encodeId=c6341e35651e1, content=<a href='/topic/show?id=687923464ae' target=_blank style='color:#2F92EE;'>#乙酰半胱氨酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23464, encryptionId=687923464ae, topicName=乙酰半胱氨酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=859133934050, createdName=yhj-time, createdTime=Wed Dec 19 13:40:00 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788725, encodeId=559c1e8872555, content=<a href='/topic/show?id=ce4314201f3' target=_blank style='color:#2F92EE;'>#photo#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14201, encryptionId=ce4314201f3, topicName=photo)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cb3a261, createdName=liuxiaona, createdTime=Sat Feb 23 18:40:00 CST 2019, time=2019-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1270047, encodeId=fa4112e00479a, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Sat Apr 28 14:40:00 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397526, encodeId=4eff139e526a7, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Sat Apr 28 14:40:00 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546304, encodeId=2fa615463042a, content=<a href='/topic/show?id=0da528e33ce' target=_blank style='color:#2F92EE;'>#光动力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28733, encryptionId=0da528e33ce, topicName=光动力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2b6213920685, createdName=luckyshitiancai_42705688, createdTime=Sat Apr 28 14:40:00 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309738, encodeId=92ff309e3845, content=学习学习.了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Fri Apr 27 08:25:25 CST 2018, time=2018-04-27, status=1, ipAttribution=)]
2018-04-28 luckyshitiancai_42705688

#光动力#

78 0
[GetPortalCommentsPageByObjectIdResponse(id=1719553, encodeId=0b971e195537c, content=<a href='/topic/show?id=404928e34f6' target=_blank style='color:#2F92EE;'>#光动力治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28734, encryptionId=404928e34f6, topicName=光动力治疗)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c432763729, createdName=wshxjq, createdTime=Thu Aug 09 11:40:00 CST 2018, time=2018-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2054924, encodeId=1e8c2054924fe, content=<a href='/topic/show?id=e2365922f4' target=_blank style='color:#2F92EE;'>#diagnosis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5922, encryptionId=e2365922f4, topicName=diagnosis)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3c932500160, createdName=ms7421025882867189, createdTime=Mon Mar 04 00:40:00 CST 2019, time=2019-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1638585, encodeId=be7116385854e, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Sep 08 01:40:00 CST 2018, time=2018-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1687016, encodeId=4ecd168e016bb, content=<a href='/topic/show?id=5f688449023' target=_blank style='color:#2F92EE;'>#脉络膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84490, encryptionId=5f688449023, topicName=脉络膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a15828309522, createdName=12498568m59暂无昵称, createdTime=Tue May 08 22:40:00 CST 2018, time=2018-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1735651, encodeId=c6341e35651e1, content=<a href='/topic/show?id=687923464ae' target=_blank style='color:#2F92EE;'>#乙酰半胱氨酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23464, encryptionId=687923464ae, topicName=乙酰半胱氨酸)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=859133934050, createdName=yhj-time, createdTime=Wed Dec 19 13:40:00 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1788725, encodeId=559c1e8872555, content=<a href='/topic/show?id=ce4314201f3' target=_blank style='color:#2F92EE;'>#photo#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14201, encryptionId=ce4314201f3, topicName=photo)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cb3a261, createdName=liuxiaona, createdTime=Sat Feb 23 18:40:00 CST 2019, time=2019-02-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1270047, encodeId=fa4112e00479a, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Sat Apr 28 14:40:00 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397526, encodeId=4eff139e526a7, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Sat Apr 28 14:40:00 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546304, encodeId=2fa615463042a, content=<a href='/topic/show?id=0da528e33ce' target=_blank style='color:#2F92EE;'>#光动力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28733, encryptionId=0da528e33ce, topicName=光动力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2b6213920685, createdName=luckyshitiancai_42705688, createdTime=Sat Apr 28 14:40:00 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=309738, encodeId=92ff309e3845, content=学习学习.了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Fri Apr 27 08:25:25 CST 2018, time=2018-04-27, status=1, ipAttribution=)]
2018-04-27 1dd8c52fm63(暂无匿称)

学习学习.了解了解

98 0

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Photodiagnosis Photodyn Ther：N-乙酰半胱氨酸防止由光动力治疗引起的脉络膜视网膜损伤

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