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Allergy Asthma Clin Immunol:儿童哮喘、过敏性鼻炎和过敏性皮肤炎共有的产前影响研究

2019-10-04 AlexYang MedSci原创

儿童过敏性疾病的增加是一个全球健康问题。最近,有研究人员调查了儿童哮喘的产前风险因素,并且强调了儿童哮喘、过敏性鼻炎(AR)和过敏性皮肤炎(AD)可能的产前共有影响。研究总共包括了628878对母亲和孩子,其中43915(6.98%)名儿童在6岁之前发展为哮喘。研究发现男性性别(aOR 1.50, 95%CI 1.47-1.53)、母亲哮喘(aOR 1.80, 95%CI 1.71-1.89)、母

儿童过敏性疾病的增加是一个全球健康问题。最近,有研究人员调查了儿童哮喘的产前风险因素,并且强调了儿童哮喘、过敏性鼻炎(AR)和过敏性皮肤炎(AD)可能的产前共有影响。

研究总共包括了628878对母亲和孩子,其中43915(6.98%)名儿童在6岁之前发展为哮喘。研究发现男性性别(aOR 1.50, 95%CI 1.47-1.53)、母亲哮喘(aOR 1.80, 95%CI 1.71-1.89)、母亲过敏性鼻炎(aOR 1.33, 95%CI 1.30-1.37)、早产(aOR 1.32, 95%CI 1.27-1.37)、低出生体重(aOR 1.14, 95%CI 1.10-1.19)和剖宫产(aOR 1.10, 95%CI 1.08-1.13)是儿童哮喘的独立预测因子。较高的城市化水平和较少的哥哥姐姐数量与哮喘呈现剂量依赖的模式。明显的是,研究人员鉴定了母亲哮喘与儿童哮喘的相关性(aOR 1.80, 95%CI 1.71-1.89)比母亲消化和儿童AR之间的相关性(aOR 1.67, 95%CI 1.50-1.87)和儿童AD的相关性(aOR 1.31, 95%CI 1.22-1.40)更强。相似的,母亲AR与儿童AR(aOR 1.62, 95%CI 1.53-1.72)相关性要比母亲AR和儿童哮喘(aOR 1.33, 95%CI 1.30-1.37)和儿童AD (aOR 1.35, 95%CI 1.31-1.40)相关性更高。更多的是,母亲过敏性疾病的数量与儿童3种过敏性呈现剂量依赖的模式。

最后,研究人员指出,他们的研究提供了母亲对儿童哮喘的影响,并阐释了儿童哮喘、AR和AD共有的母亲方面的影响。

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    2020-01-05 skhzy
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    2019-10-06 膀胱癌
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    2019-10-06 qilu_qi

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【1】Rhinology:泛福舒能够通过改善Th1/Th2细胞因子平衡减轻永久过敏性鼻炎 https://www.ncbi.nlm.nih.gov/pubmed/31403136益生菌主要分布在粘膜系统且能够增强粘膜障碍功能和调控免疫响应。泛福舒(BV)是一种益生菌,已经用于呼吸道感染患者的治疗,但是对过敏性鼻炎可能的效果仍旧没有评估。最近,有研究人员调查了BV在永久AR患者中的临床疗效,并阐

Immunotherapy:益生菌提取物的鼻腔滴注能够抑制试验过敏性鼻炎

过敏性鼻炎(AR)是一种常见的疾病。AR的治疗效果仍旧需要改善。最近,有研究人员评估了局部益生菌提取物给药对抑制试验性AR的效果情况。研究人员将上皮细胞(ECs)与丁酸梭菌提取物(CBe)共培养提高IL-10的表达,并建立了小鼠AR模型来评估CBe对AR的影响。研究发现,CBe能够显著的诱导IL-10在ECs中的表达。而B细胞与CBe处理的ECs共培养也能够显著的增加B细胞(iB-10)中IL-1

Clin Otolaryngol:鼻用中药软膏Biyeom-go治疗鼻炎相关鼻症状的前瞻性观察研究

最近,有研究人员调查了Biyeom-go在治疗鼻炎相关鼻症状中的效果和临床可行性情况。研究是一个前瞻性的观察性研究。研究包括了58名患有鼻炎的患者。所有的患者均接受每天大于3次的Biyeom-go治疗,总共进行4周。研究的主要结果为总的鼻症状评分。研究发现,Biyeom-go给药与总鼻症状评分(p<0.0001)、微型鼻结膜炎生活质量问卷评分(p<0.0001)的改善显著相关,并且是时

Allergol Immunopathol (Madr):过敏性鼻炎儿童中鼻粘膜纤毛清除及疾病严重程度关系分析

鼻粘膜清除(MCC)由于过敏性鼻炎中的慢性炎症而受到损伤。最近,有研究人员评估了MCC在过敏性鼻炎儿童中的情况,并确定了与疾病严重度的关系,评估了MCC在鼻腔灌洗后的变化情况。研究人员在51名过敏性鼻炎患者和50名对照中进行了糖精测试。研究人员对患者进行鼻腔灌洗并每10分钟进行一次糖精测试,并记录了总鼻症状评分(TNSS)和视觉模拟评分(VAS)结果。研究人员根据TNSS、VAS和ARIA指南将患

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