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Diabetes Care:“神药”二甲双胍使用与GDF15有关

2017-01-04 佚名 生物探索

最广泛使用的2型糖尿病药物、抗癌、抗衰老,二甲双胍因具有治疗多种疾病的潜能一直备受关注。今天,小编要为大家介绍的一项研究进展与“神药”二甲双胍的生物标志物有关。2016年12月14日,发表在Diabetes Care杂志上题为“Growth Differentiation Factor 15 as a Novel Biomarker for Metformin”的研究中,科学家们发现了二甲双胍使用

最广泛使用的2型糖尿病药物、抗癌、抗衰老,二甲双胍因具有治疗多种疾病的潜能一直备受关注。今天,小编要为大家介绍的一项研究进展与“神药”二甲双胍的生物标志物有关。

2016年12月14日,发表在Diabetes Care杂志上题为“Growth Differentiation Factor 15 as a Novel Biomarker for Metformin”的研究中,科学家们发现了二甲双胍使用和剂量的新型生物标志物——GDF15(The growth differentiation factor 15)。加拿大麦克马斯特大学的Hertzel C. Gerstein博士是这一研究的通讯作者兼第一作者。

具体来说,为了鉴定与二甲双胍剂量或使用相关的标志物,研究小组评估了参与者237种血清生物标志物。这些参与者来自一个名为“Outcome Reduction with Initial Glargine Intervention”(ORIGIN) 的试验,8401人中有2317人服用二甲双胍。


A 1.64 ng/mL higher GDF15 level predicted a 188-mg higher metformin dose (P < 0.0001)

最终,研究人员发现,GDF15与二甲双胍密切相关。GDF15水平每增加一个标准差,二甲双胍使用的几率就会从3.73增加到3.94。其它25种相关标志物与二甲双胍使用之间的关联见下表:


作者们在论文中写道,GDF15水平是患有血糖代谢障碍的人二甲双胍使用的生物标志物,且它的浓度反应了二甲双胍的剂量。二甲双胍作用机制及其对多种其它疾病的影响是目前研究的热点方向之一。新型生物标志物的发现将为这些研究提供新的工具。

原始出处:

Gerstein HC, Pare G, Hess S, Ford RJ, Sjaarda J, Raman K, McQueen M, Lee S, Haenel H, Steinberg GR; ORIGIN Investigators.. Growth Differentiation Factor 15 as a Novel Biomarker for Metformin. Diabetes Care. 2016 Dec 14. pii: dc161682

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    backKKK

    0

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    2017-01-04 大旺旺

    学习了啊

    0

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    2017-01-04 雅文博武

    学习了很多先进的医学知识讲座

    0

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    2017-01-04 雾夜芭蕾

    二甲双胍其实是植物药

    0

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    2017-01-04 雾夜芭蕾

    新型生物标志确实很多

    0

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    2017-01-04 yafeiliutjh

    新发现呀

    0

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