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Br J Sports Med:随着体力活动的减少,成年人代谢性疾病的风险增加!

2021-09-18 xiaozeng MedSci原创

保持一定的运动量,对于代谢性疾病风险日趋增加的中年人百利而无一害

代谢性疾病,包括2型糖尿病和脂代谢紊乱,都是血管疾病(CVD)的已明确的风险因素。尽管我们了解中-高强度体力活动 (MVPA) 在预防2型糖尿病和血脂异常方面的一般益处,但缺乏关于青年期MVPA的特定轨迹以及MVPA轨迹组与成年期CVD的关联的纵向数据。

本研究旨在确定在成年过程中的中-高强度体力活动(MVPA)轨迹与代谢性疾病(糖尿病和脂代谢紊乱)发作之间的相关性。

研究人员分析了年轻成年人研究冠状动脉风险发展研究的5115位受试者的前瞻性以社区为基础的队列数据,受试者为基线18-30岁(1985-1986年)的黑人和白人,随访了30年。采用线性混合模型为每位受试者开发了个性化的 MVPA 轨迹。

不同分类受试者MVPA随年龄增长的变化

18 岁时较低的估计 MVPA 评分与糖尿病发病几率高 12%(95% CI 6%-18%)、偶发性低水平高密度脂蛋白(HDL)发病几率高 4%(1%-7%)以及偶发性高甘油三酯发病几率高 6%(2%-11%)相关。MVPA 评分每降低 1 个单位,糖尿病的年发病率会增加 6%(95% CI 4%-9%),高甘油三酯的年发病率增加 4%(95% CI 2%-6%)。

MVPA轨迹与代谢性疾病的相关性

分析各种 MVPA 轨迹组,在 18 岁时处于最活跃组(每周活动时间超过 300 分钟),但在中年时活动量急剧下降的受试者,与从18岁起一直处于最活跃组的受试者相比,高密度脂蛋白水平降低和低密度脂蛋白水平升高的发生率更高。

综上,鉴于成年人中-高强度体力活动下降的趋势和相关代谢疾病风险增加的趋势,青年期是增加干预措施和开始维持中-高强度体力活动的重要时期。总之,保持一定的运动量,对于代谢性疾病风险日趋增加的中年人而言,百利而无一害!

原始出处:

Nagata Jason M,Vittinghoff Eric,Pettee Gabriel Kelley et al. Moderate-to-vigorous intensity physical activity from young adulthood to middle age and metabolic disease: a 30-year population-based cohort study.[J] .Br J Sports Med, 2021, https://doi.org/10.1136/bjsports-2021-104231

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    2022-05-19 sodoo
  2. [GetPortalCommentsPageByObjectIdResponse(id=1989607, encodeId=6e12198960eb9, content=<a href='/topic/show?id=5e202543023' target=_blank style='color:#2F92EE;'>#代谢性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25430, encryptionId=5e202543023, topicName=代谢性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6cc1239, createdName=sodoo, createdTime=Thu May 19 07:13:37 CST 2022, time=2022-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1611256, encodeId=cb2816112569f, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Sep 20 04:13:37 CST 2021, time=2021-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052957, encodeId=86a1105295ed8, content=多活动总是好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210804/5785b262ac614e2787c8b09e8d8ae840/5cf1162cd10d42bc817ae4b32662d7f8.jpg, createdBy=c27d4938136, createdName=小小的丁香花, createdTime=Sun Sep 19 08:00:03 CST 2021, time=2021-09-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052775, encodeId=ebe81052e7511, content=<a href='/topic/show?id=4f77e665253' target=_blank style='color:#2F92EE;'>#糖尿病#</a>动起来,更健康, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76652, encryptionId=4f77e665253, topicName=糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210725/69b5882b3c3845c19efa131b4ff8b1f7/06ccd8f1857e4e14862049ab235618eb.jpg, createdBy=74c72110107, createdName=Nebula-Qin, createdTime=Sat Sep 18 13:27:58 CST 2021, time=2021-09-18, status=1, ipAttribution=)]
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    2021-09-19 小小的丁香花

    多活动总是好的

    0

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    2021-09-18 Nebula-Qin

    #糖尿病#动起来,更健康

    0

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