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Ann Rheum Dis :SpA疾病结局中个人层面和国家层面的社会经济决定因素

2019-01-29 xiangting MedSci原创

SpA患者中也存在个体水平和国家水平的健康不平等。女性和受教育程度低的患者疾病活动性和身体机能更差。

这项研究旨在探讨个人层面和国家层面的社会经济地位(SES)决定因素对脊柱关节炎(SpA)患者疾病活动性和躯体功能的独立影响。

使用来自横断面、多国(全球范围22个国家)COMOSPA研究(SpA中的并发症)的数据。调整临床和人口学混杂因素后,在多级回归模型中分析了个体SES因素(性别、教育)和居住国家对强直性脊柱炎疾病活动性评分(ASDAS)和Bath强直性脊柱炎功能指数(BASFI)的影响。其次,还探讨了国家宏观经济指标(国内生产总值[GDP]、人类发展指数、医疗保健支出和基尼指数)的额外影响。通过检验间接效应,探讨了使用生物性疾病改善抗风湿药物在教育或GDP与ASDAS之间的介导作用。

共纳入3370名SpA患者:65%为男性,平均年龄43岁(SD 14),ASDAS为2.0(SD 1.1),BASFI评分为3.1(SD 2.7)。在调整后的模型中,受教育程度低患者和女性患者的OR值分别为1.7(95%CI 1.3至2.2)和1.7(95%CI 1.4至2.0),ASDAS≥2.1。受教育程度低患者和女性患者的功能略差。观察到国家间的差异很大,与个体SES和临床混杂因素无关。来自SES较低国家患者的ASDAS较差,而BASFI类型无显著差异。使用生物性药物并不介导个体水平或国家水平SES与疾病活动性间的关系。

SpA患者中也存在个体水平和国家水平的健康不平等。女性和受教育程度低的患者疾病活动性和身体机能更差。虽然社会经济不发达国家的患者疾病活动性更高,但其报告的躯体功能相似。


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    2019-10-02 gostraight
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