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J Periodontol:家族性地中海热和慢性牙周炎患者唾液氧化应激的评价

2018-09-25 MedSci MedSci原创

家族性地中海热(FMF)是一种固有的自身炎症性疾病,在地中海国家流行率很高。本研究的目的是评估FMF和慢性牙周炎患者的唾液水平的氧化应激参数。

家族性地中海热(FMF)是一种固有的自身炎症性疾病,在地中海国家流行率很高。本研究的目的是评估FMF和慢性牙周炎患者的唾液水平的氧化应激参数。

方法:研究人群包括81名FMF患者和85名系统健康对照。试验组和对照组分为慢性牙周炎和牙周健康[FMF-牙周炎(n = 37); FMF-牙周健康(n = 44);全身健康 - 牙周炎(n = 37);全身和牙周健康(n = 48)。收集全部的唾液样本。临床牙周参数包括菌斑指数,牙龈指数(GI),探诊深度(PD),探诊出血百分比(BOP%)和临床附着水平测量(CAL)。评价唾液总抗氧化状态(TAS),总氧化剂状态(TOS),8-羟基脱氧鸟苷(8-OHdG),丙二醛(MDA)和氧化应激指数(OSI)。

结果:FMF-牙周炎组的8-OHdG,MDA和OSI水平显着高于FMF-牙周健康组。在FMF-牙周炎组中,PD,8-OHdG,MDA和OSI水平显着高于全身健康 - 牙周炎组(分别为P = 0.035,P = 0.000,P = 0.000和P = 0.000)。 8-OHdG值与BOP%和GI显着相关,TOS值与FMF-牙周炎组的PD和CAL显着相关。

在FMF和慢性牙周炎的存在下,唾液水平的氧化应激增加。因此,氧化应激可能是FMF和慢性牙周炎中重要的炎症机制。进一步的研究需要阐明FMF和慢性牙周炎的氧化机制。

原始出处:

Gozde Dinc, et al.The evaluation of salivary oxidative stress in patients with familial Mediterranean fever and chronic periodontitis. Journal of  Periodontology. 2018 September. Doi:10.1002/JPER.17-0638

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2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629542, encodeId=f7ce1629542bb, content=<a href='/topic/show?id=c61d4641821' target=_blank style='color:#2F92EE;'>#家族性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46418, encryptionId=c61d4641821, topicName=家族性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Thu Sep 27 12:14:00 CST 2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346618, encodeId=f04234661899, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Tue Sep 25 21:43:08 CST 2018, time=2018-09-25, status=1, ipAttribution=)]
    2018-09-27 huagfeg
  5. 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2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629542, encodeId=f7ce1629542bb, content=<a href='/topic/show?id=c61d4641821' target=_blank style='color:#2F92EE;'>#家族性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46418, encryptionId=c61d4641821, topicName=家族性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Thu Sep 27 12:14:00 CST 2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346618, encodeId=f04234661899, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Tue Sep 25 21:43:08 CST 2018, time=2018-09-25, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1924305, encodeId=e7e81924305dc, content=<a href='/topic/show?id=ff7f464238f' target=_blank style='color:#2F92EE;'>#家族性地中海热#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46423, encryptionId=ff7f464238f, topicName=家族性地中海热)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/vLodSSFTQLpHtfwJicWJibSWH7pbiauxvpCMvQIv0N9Oes8vHkDkCIW2HNDkt7icUq3RCZiaDcHR9Rap17fFySRbiaFg/132, createdBy=9f202500205, createdName=ms3297076796458174, createdTime=Sun Aug 11 02:14:00 CST 2019, time=2019-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727615, encodeId=22f81e27615b2, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, 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encodeId=f8a0145102016, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Thu Sep 27 12:14:00 CST 2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1575483, encodeId=e54c15e548321, content=<a href='/topic/show?id=cd9941326bc' target=_blank style='color:#2F92EE;'>#地中海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41326, encryptionId=cd9941326bc, topicName=地中海)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=303116130321, createdName=wgx311, createdTime=Thu Sep 27 12:14:00 CST 2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629542, encodeId=f7ce1629542bb, content=<a href='/topic/show?id=c61d4641821' target=_blank style='color:#2F92EE;'>#家族性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46418, encryptionId=c61d4641821, topicName=家族性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Thu Sep 27 12:14:00 CST 2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346618, encodeId=f04234661899, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Tue Sep 25 21:43:08 CST 2018, time=2018-09-25, status=1, ipAttribution=)]
  7. 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encodeId=f8a0145102016, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=125, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Thu Sep 27 12:14:00 CST 2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1575483, encodeId=e54c15e548321, content=<a href='/topic/show?id=cd9941326bc' target=_blank style='color:#2F92EE;'>#地中海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41326, encryptionId=cd9941326bc, topicName=地中海)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=303116130321, createdName=wgx311, createdTime=Thu Sep 27 12:14:00 CST 2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629542, encodeId=f7ce1629542bb, content=<a href='/topic/show?id=c61d4641821' target=_blank style='color:#2F92EE;'>#家族性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46418, encryptionId=c61d4641821, topicName=家族性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Thu Sep 27 12:14:00 CST 2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346618, encodeId=f04234661899, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Tue Sep 25 21:43:08 CST 2018, time=2018-09-25, status=1, ipAttribution=)]
    2018-09-27 wgx311
  8. 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  9. 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2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629542, encodeId=f7ce1629542bb, content=<a href='/topic/show?id=c61d4641821' target=_blank style='color:#2F92EE;'>#家族性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46418, encryptionId=c61d4641821, topicName=家族性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Thu Sep 27 12:14:00 CST 2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346618, encodeId=f04234661899, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Tue Sep 25 21:43:08 CST 2018, time=2018-09-25, status=1, ipAttribution=)]
    2018-09-25 天地飞扬

    了解一下,谢谢分享!

    0

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