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JAMA Netw Open:低温大气电浆可加快糖尿病足溃疡的伤口愈合

2021-05-10 MedSci原创 MedSci原创

糖尿病足溃疡是糖尿病的一种常见并发症,需要专门的治疗。既往小样本系列病例报告中,低温大气电浆(CAP)有益于治疗伤口感染促进愈合。然而,与标准护理疗法相比,CAP对糖尿病足溃疡的伤口愈合的影响仍有待研

糖尿病足溃疡是糖尿病的一种常见并发症,需要专门的治疗。既往小样本系列病例报告中,低温大气电浆(CAP)有益于治疗伤口感染促进愈合。然而,与标准护理疗法相比,CAP对糖尿病足溃疡的伤口愈合的影响仍有待研究。近日,研究人员进行了一项前瞻性、随机、安慰剂对照、患者盲法的临床试验,旨在确定与标准护理疗法相比,CAP是否能加速糖尿病足溃疡的伤口愈合,研究结果已发表于JAMA Netw Open。

研究在2家诊所进行,2016年8月17日至2019年4月20日招募了45名糖尿病足溃疡患者,随访至2024年4月30日。统计患者的足溃疡数目,随机分组,分别接受标准护理治疗,8次应用CAP,或8次应用安慰剂治疗。主要终点是与治疗开始时相比,足溃疡伤口大小、临床感染和微生物量减少。次要终点是相关伤口缩小(>10%)的时间,感染的减少,病人的幸福感参数,以及治疗相关的不良事件。

 

研究纳入的45名糖尿病患者的65个足溃疡伤口中,29名患者的33个伤口被随机分配到CAP,28名患者的32个伤口被分配到安慰剂,最终评估包括43名患者的62个伤口(每组31个伤口)(平均[SD]年龄,68.5[9.1]岁)。CAP组4名患者(共31个伤口,其中5个伤口,16.1%),安慰剂组3名患者(共31个伤口,其中4个伤口,13%)是活跃的吸烟者。

 

分析结果显示,无论是平均(SD)总面积减少量(CAP VS. 安慰剂相对单位,-26.31[11.72];P = .03)还是相关伤口面积减少的平均(SD)时间(CAP VS. 安慰剂相对单位,从基线10%,1.60 [0.58];P = .009),CAP治疗都显著提高伤口的愈合率。感染和微生物量的减少方面,CAP和安慰剂之间没有明显差异。治疗期间没有发生与治疗相关的不良事件;患者在治疗期间的感受相似。

综上所述,该研究结果表明,在这项随机临床试验中,CAP疗法有益于加快慢性伤口的愈合,无论有无感染。

 

原始出处:

 

Bernd Stratmann, et al., Effect of Cold Atmospheric Plasma Therapy vs Standard Therapy Placebo on Wound Healing in Patients With Diabetic Foot Ulcers: A Randomized Clinical Trial. JAMA Netw Open. 2020 Jul 1;3(7):e2010411. doi: 10.1001/jamanetworkopen.2020.10411.

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    2021-11-20 feather89
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    2022-01-17 canlab
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    2021-05-10 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1728940, encodeId=f1871e2894092, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sat Nov 20 19:18:55 CST 2021, time=2021-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1734359, encodeId=bc4c1e3435909, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Mon Jan 17 04:18:55 CST 2022, time=2022-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1648561, encodeId=f7f7164856139, content=<a href='/topic/show?id=531793000f9' target=_blank style='color:#2F92EE;'>#足溃疡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93000, encryptionId=531793000f9, topicName=足溃疡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=943123606403, createdName=meichuangyi, createdTime=Tue Aug 24 15:18:55 CST 2021, time=2021-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1309913, encodeId=b13013099138d, content=<a href='/topic/show?id=5e6926003ae' target=_blank style='color:#2F92EE;'>#伤口愈合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26003, encryptionId=5e6926003ae, topicName=伤口愈合)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8949377, createdName=chenzhuanggui, createdTime=Wed May 12 03:18:55 CST 2021, time=2021-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512549, encodeId=c2b61512549c3, content=<a href='/topic/show?id=881ce679132' target=_blank style='color:#2F92EE;'>#糖尿病足溃疡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76791, encryptionId=881ce679132, topicName=糖尿病足溃疡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a50210475224, createdName=ms3875500703114551, createdTime=Wed May 12 03:18:55 CST 2021, time=2021-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1036602, encodeId=c613103660281, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Mon May 10 15:18:55 CST 2021, time=2021-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043600, encodeId=1d81104360055, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Mon May 10 15:18:55 CST 2021, time=2021-05-10, status=1, ipAttribution=)]
    2021-05-10 misszhang

    谢谢MedSci提供最新的资讯

    0

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糖尿病足溃疡愈合缓慢,常常合并感染,给患者造成沉重的负担。临床研究表明,人类皮肤类似物移植可促进糖尿病足溃疡愈合。 为了探讨同种异体羊膜/绒毛膜移植是否可以缩短糖尿病足溃疡愈合时间,以及,每周一次人脱水羊膜/绒毛膜移植是否比两周一次人脱水羊膜/绒毛膜移植更有效,来自美国巴里大学医学院的Zelen教授及其团队进行了一项研究。该研究结果在线发表在2014年02月21日的International W

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