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JAHA:非心脏手术患者新发术后房颤的病程特点

2021-03-19 MedSci原创 MedSci原创

非心脏手术后POAF患者中AF复发的比例为16.8%。AF复发与较高的不良临床结局风险相关。考虑到抗凝相关出血的高风险,应在该人群中仔细权衡常规抗凝的益处。主动监测AF复发十分必要。

术后房颤(POAF)在心脏手术后很常见,但对于非心脏手术后其发生率和自然病程知之甚少。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员评估了POAF的自然病程和临床影响,以及抗凝治疗对无房颤史的非心脏手术患者的长期影响。

研究人员回顾性分析了Asan医学中心(韩国首尔)的数据库,旨在明确2006年1月至2016年1月期间接受非心脏手术后新发POAF的患者。该研究的主要结局为房颤复发、血栓栓塞事件和随访期间的大出血。

在322688例接受非心脏手术的患者中,有315例(平均年龄为66.4岁;男性为64.4%)患者出现新发POAF,出院后定期进行心律监测。随访2年期间,53例(16.8%)患者出现AF复发。高血压(风险比为2.12;P=0.02)、中度至重度左心房扩大(风险比为2.33;P=0.007)与复发独立相关。与没有复发性AF患者相比,复发性AF患者发生血栓栓塞事件(11.2% vs. 0.8%;P<0.001)和大出血(26.9% vs. 4.1%;P<0.001)的风险更高。未进行抗凝治疗的AF复发患者尤其容易发生血栓栓塞事件(P<0.001)。总体而言,抗凝治疗与血栓栓塞事件没有显著相关性(1.4% vs. 2.5%,P=0.95)。

由此可见,非心脏手术后POAF患者中AF复发的比例为16.8%。AF复发与较高的不良临床结局风险相关。考虑到抗凝相关出血的高风险,应在该人群中仔细权衡常规抗凝的益处。主动监测AF复发十分必要

原始出处:

Junho Hyun.et al.Natural Course of New‐Onset Postoperative Atrial Fibrillation after Noncardiac Surgery.J AM HEART ASSOC.2021.https://www.ahajournals.org/doi/full/10.1161/JAHA.120.018548

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    2021-03-21 zhaohui6731
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  5. [GetPortalCommentsPageByObjectIdResponse(id=2066841, encodeId=2a1e2066841f7, content=<a href='/topic/show?id=fe1a6106394' target=_blank style='color:#2F92EE;'>#术后房颤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61063, encryptionId=fe1a6106394, topicName=术后房颤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24a22500182, createdName=1696533704_45270454, createdTime=Sat Jun 26 21:33:15 CST 2021, time=2021-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819301, encodeId=634418193017d, content=<a href='/topic/show?id=aba89940943' target=_blank style='color:#2F92EE;'>#非心脏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99409, encryptionId=aba89940943, topicName=非心脏)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=917c196, createdName=sjzlzc007, createdTime=Thu Sep 02 10:33:15 CST 2021, time=2021-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268464, encodeId=1897126846454, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sun Mar 21 11:33:15 CST 2021, time=2021-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488301, encodeId=b7721488301d5, content=<a href='/topic/show?id=f37799413a6' target=_blank style='color:#2F92EE;'>#非心脏手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99413, encryptionId=f37799413a6, topicName=非心脏手术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b5438409695, createdName=bnurmamat, createdTime=Sun Mar 21 11:33:15 CST 2021, time=2021-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031364, encodeId=48a810313642c, content=房颤,临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Fri Mar 19 23:33:15 CST 2021, time=2021-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949588, encodeId=70f7949588ac, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd5c2462821, createdName=储酒仙, createdTime=Fri Mar 19 21:39:42 CST 2021, time=2021-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949587, encodeId=42ca94958ede, content=进来学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200627/83a502bff6c14b759a7d0863b4068e7b/32ad40676056418ea58a94afac9c5b81.jpg, createdBy=6f475314305, createdName=水-晶, createdTime=Fri Mar 19 21:35:22 CST 2021, time=2021-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949580, encodeId=5e14949580cb, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=40982815356, createdName=penghaiwen, createdTime=Fri Mar 19 20:50:58 CST 2021, time=2021-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949579, encodeId=781f9495e9dc, content=👍🏻👍🏻, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5935456773, createdName=ms4000001054197562, createdTime=Fri Mar 19 20:49:31 CST 2021, time=2021-03-19, status=1, ipAttribution=)]
    2021-03-19 心介

    房颤,临床上碰到很多哦

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2066841, encodeId=2a1e2066841f7, content=<a href='/topic/show?id=fe1a6106394' target=_blank style='color:#2F92EE;'>#术后房颤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61063, encryptionId=fe1a6106394, topicName=术后房颤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24a22500182, createdName=1696533704_45270454, createdTime=Sat Jun 26 21:33:15 CST 2021, time=2021-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819301, encodeId=634418193017d, content=<a href='/topic/show?id=aba89940943' target=_blank style='color:#2F92EE;'>#非心脏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99409, encryptionId=aba89940943, topicName=非心脏)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=917c196, createdName=sjzlzc007, createdTime=Thu Sep 02 10:33:15 CST 2021, time=2021-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268464, encodeId=1897126846454, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sun Mar 21 11:33:15 CST 2021, time=2021-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488301, encodeId=b7721488301d5, content=<a href='/topic/show?id=f37799413a6' target=_blank style='color:#2F92EE;'>#非心脏手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99413, encryptionId=f37799413a6, topicName=非心脏手术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b5438409695, createdName=bnurmamat, createdTime=Sun Mar 21 11:33:15 CST 2021, time=2021-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031364, encodeId=48a810313642c, content=房颤,临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Fri Mar 19 23:33:15 CST 2021, time=2021-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949588, encodeId=70f7949588ac, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd5c2462821, createdName=储酒仙, createdTime=Fri Mar 19 21:39:42 CST 2021, time=2021-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949587, encodeId=42ca94958ede, content=进来学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200627/83a502bff6c14b759a7d0863b4068e7b/32ad40676056418ea58a94afac9c5b81.jpg, createdBy=6f475314305, createdName=水-晶, createdTime=Fri Mar 19 21:35:22 CST 2021, time=2021-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949580, encodeId=5e14949580cb, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=40982815356, createdName=penghaiwen, createdTime=Fri Mar 19 20:50:58 CST 2021, time=2021-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949579, encodeId=781f9495e9dc, content=👍🏻👍🏻, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5935456773, createdName=ms4000001054197562, createdTime=Fri Mar 19 20:49:31 CST 2021, time=2021-03-19, status=1, ipAttribution=)]
    2021-03-19 储酒仙

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2066841, encodeId=2a1e2066841f7, content=<a href='/topic/show?id=fe1a6106394' target=_blank style='color:#2F92EE;'>#术后房颤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61063, encryptionId=fe1a6106394, topicName=术后房颤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24a22500182, createdName=1696533704_45270454, createdTime=Sat Jun 26 21:33:15 CST 2021, time=2021-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819301, encodeId=634418193017d, content=<a href='/topic/show?id=aba89940943' target=_blank style='color:#2F92EE;'>#非心脏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99409, encryptionId=aba89940943, topicName=非心脏)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=917c196, createdName=sjzlzc007, createdTime=Thu Sep 02 10:33:15 CST 2021, time=2021-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268464, encodeId=1897126846454, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sun Mar 21 11:33:15 CST 2021, time=2021-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488301, encodeId=b7721488301d5, content=<a href='/topic/show?id=f37799413a6' target=_blank style='color:#2F92EE;'>#非心脏手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99413, encryptionId=f37799413a6, topicName=非心脏手术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b5438409695, createdName=bnurmamat, createdTime=Sun Mar 21 11:33:15 CST 2021, time=2021-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031364, encodeId=48a810313642c, content=房颤,临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Fri Mar 19 23:33:15 CST 2021, time=2021-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949588, encodeId=70f7949588ac, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd5c2462821, createdName=储酒仙, createdTime=Fri Mar 19 21:39:42 CST 2021, time=2021-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949587, encodeId=42ca94958ede, content=进来学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200627/83a502bff6c14b759a7d0863b4068e7b/32ad40676056418ea58a94afac9c5b81.jpg, createdBy=6f475314305, createdName=水-晶, createdTime=Fri Mar 19 21:35:22 CST 2021, time=2021-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949580, encodeId=5e14949580cb, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=40982815356, createdName=penghaiwen, createdTime=Fri Mar 19 20:50:58 CST 2021, time=2021-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949579, encodeId=781f9495e9dc, content=👍🏻👍🏻, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5935456773, createdName=ms4000001054197562, createdTime=Fri Mar 19 20:49:31 CST 2021, time=2021-03-19, status=1, ipAttribution=)]
    2021-03-19 水-晶

    进来学习了

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2066841, encodeId=2a1e2066841f7, content=<a href='/topic/show?id=fe1a6106394' target=_blank style='color:#2F92EE;'>#术后房颤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61063, encryptionId=fe1a6106394, topicName=术后房颤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24a22500182, createdName=1696533704_45270454, createdTime=Sat Jun 26 21:33:15 CST 2021, time=2021-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1819301, encodeId=634418193017d, content=<a href='/topic/show?id=aba89940943' target=_blank style='color:#2F92EE;'>#非心脏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99409, encryptionId=aba89940943, topicName=非心脏)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=917c196, createdName=sjzlzc007, createdTime=Thu Sep 02 10:33:15 CST 2021, time=2021-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268464, encodeId=1897126846454, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sun Mar 21 11:33:15 CST 2021, time=2021-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488301, encodeId=b7721488301d5, content=<a href='/topic/show?id=f37799413a6' target=_blank style='color:#2F92EE;'>#非心脏手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99413, encryptionId=f37799413a6, topicName=非心脏手术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b5438409695, createdName=bnurmamat, createdTime=Sun Mar 21 11:33:15 CST 2021, time=2021-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031364, encodeId=48a810313642c, content=房颤,临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Fri Mar 19 23:33:15 CST 2021, time=2021-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949588, encodeId=70f7949588ac, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd5c2462821, createdName=储酒仙, createdTime=Fri Mar 19 21:39:42 CST 2021, time=2021-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949587, encodeId=42ca94958ede, content=进来学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200627/83a502bff6c14b759a7d0863b4068e7b/32ad40676056418ea58a94afac9c5b81.jpg, createdBy=6f475314305, createdName=水-晶, createdTime=Fri Mar 19 21:35:22 CST 2021, time=2021-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949580, encodeId=5e14949580cb, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=40982815356, createdName=penghaiwen, createdTime=Fri Mar 19 20:50:58 CST 2021, time=2021-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=949579, encodeId=781f9495e9dc, content=👍🏻👍🏻, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5935456773, createdName=ms4000001054197562, createdTime=Fri Mar 19 20:49:31 CST 2021, time=2021-03-19, status=1, ipAttribution=)]
    2021-03-19 penghaiwen

    0

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    2021-03-19 ms4000001054197562

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