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Thyroid:人绒毛膜促性腺激素、孕妇游离甲状腺素与妊娠糖尿病之间的关联

2021-03-03 MedSci原创 MedSci原创

妊娠早期hCG升高与GDM风险降低有关。母体FT4可能是该相关联的重要介导因素。

人绒毛膜促性腺激素(hCG)是胎盘功能的标志物,也可刺激母体甲状腺功能。孕妇甲状腺功能可能与妊娠糖尿病(GDM)的病理生理学机制有关。

近日,甲状腺疾病领域权威杂志Thyroid上发表了一篇研究文章,这项研究旨在探究妊娠早期hCG浓度是否与GDM相关,以及是否通过母体甲状腺激素来介导。

该研究纳入了2015年1月至2016年12月期间在上海一家三级医院就诊的18683名孕妇。根据美国糖尿病协会指南,研究人员使用2小时75克口服葡萄糖耐量测试(OGTT)来诊断GDM,并使用多变量logistic或线性回归模型来识别其相关性,并根据孕妇年龄、受教育程度、糖尿病家族史、胎次、胎儿性别、甲状腺过氧化物酶抗体(TPOAb)和孕前体重指数(BMI)进行调整。

在OGTT期间,hCG浓度与较低的血糖相关,但与妊娠早期检测的空腹血糖或血红蛋白A1c浓度无关。妊娠早期hCG水平与GDM风险呈负相关(p=0.027)。介导分析发现hCG与GDM风险之间的相关性中约有21.4%是通过游离甲状腺素(FT4)浓度的变化所介导(p<0.05)。在仅限于TPOAb阳性女性的敏感性分析中,hCG与GDM无关(p=0.452)。

由此可见,妊娠早期hCG升高与GDM风险降低有关。母体FT4可能是该相关联的重要介导因素

原始出处:

Yindi Liu,et al.Associations between Human Chorionic Gonadotropin, Maternal Free Thyroxine, and Gestational Diabetes Mellitus.Thyroid.2021.https://www.liebertpub.com/doi/10.1089/thy.2020.0356

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    2021-03-04 ms7000001977435667

    编译能力还有很大的提升空间

    0

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    2021-03-11 148aa736m21暂无昵称

    学习

    0

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  5. [GetPortalCommentsPageByObjectIdResponse(id=2060722, encodeId=47e02060e22d9, content=<a href='/topic/show?id=48522e070f0' target=_blank style='color:#2F92EE;'>#促性腺激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27070, encryptionId=48522e070f0, topicName=促性腺激素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76d3356, createdName=tongyongming, createdTime=Fri May 28 00:49:05 CST 2021, time=2021-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945505, encodeId=6179945505d0, content=编译能力还有很大的提升空间, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63c65465535, createdName=ms7000001977435667, createdTime=Thu Mar 04 17:41:44 CST 2021, time=2021-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=947423, encodeId=3b7994e4235f, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7af65320876, createdName=148aa736m21暂无昵称, createdTime=Thu Mar 11 15:08:42 CST 2021, time=2021-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1510589, encodeId=283f151058931, content=<a href='/topic/show?id=0032663e6ff' target=_blank style='color:#2F92EE;'>#游离甲状腺素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66376, encryptionId=0032663e6ff, topicName=游离甲状腺素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a0410217579, createdName=xqptu, createdTime=Fri Mar 05 05:49:05 CST 2021, time=2021-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945208, encodeId=b9c59452080c, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210301/28e81c1eda64491ea0507710c5173138/2e20c197213f4d2bb2c03374b04301e6.jpg, createdBy=bfa51746861, createdName=Angela, createdTime=Wed Mar 03 18:01:45 CST 2021, time=2021-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043523, encodeId=aef31043523d1, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Mar 03 17:49:05 CST 2021, time=2021-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945197, encodeId=a36694519e20, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Mar 03 16:59:52 CST 2021, time=2021-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945129, encodeId=6b2a945129f1, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210303/66c17b62a9f144ea8281a5b0894d47e4/c6a5dc1e748547fbb2995fbdb3ecbb88.jpg, createdBy=5dee5415333, createdName=ms7000001038472057, createdTime=Wed Mar 03 14:57:34 CST 2021, time=2021-03-03, status=1, ipAttribution=)]
    2021-03-03 Angela

    好文章

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2060722, encodeId=47e02060e22d9, content=<a href='/topic/show?id=48522e070f0' target=_blank style='color:#2F92EE;'>#促性腺激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27070, encryptionId=48522e070f0, topicName=促性腺激素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76d3356, createdName=tongyongming, createdTime=Fri May 28 00:49:05 CST 2021, time=2021-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945505, encodeId=6179945505d0, content=编译能力还有很大的提升空间, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63c65465535, createdName=ms7000001977435667, createdTime=Thu Mar 04 17:41:44 CST 2021, time=2021-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=947423, encodeId=3b7994e4235f, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7af65320876, createdName=148aa736m21暂无昵称, createdTime=Thu Mar 11 15:08:42 CST 2021, time=2021-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1510589, encodeId=283f151058931, content=<a href='/topic/show?id=0032663e6ff' target=_blank style='color:#2F92EE;'>#游离甲状腺素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66376, encryptionId=0032663e6ff, topicName=游离甲状腺素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a0410217579, createdName=xqptu, createdTime=Fri Mar 05 05:49:05 CST 2021, time=2021-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945208, encodeId=b9c59452080c, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210301/28e81c1eda64491ea0507710c5173138/2e20c197213f4d2bb2c03374b04301e6.jpg, createdBy=bfa51746861, createdName=Angela, createdTime=Wed Mar 03 18:01:45 CST 2021, time=2021-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043523, encodeId=aef31043523d1, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Mar 03 17:49:05 CST 2021, time=2021-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945197, encodeId=a36694519e20, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Mar 03 16:59:52 CST 2021, time=2021-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945129, encodeId=6b2a945129f1, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210303/66c17b62a9f144ea8281a5b0894d47e4/c6a5dc1e748547fbb2995fbdb3ecbb88.jpg, createdBy=5dee5415333, createdName=ms7000001038472057, createdTime=Wed Mar 03 14:57:34 CST 2021, time=2021-03-03, status=1, ipAttribution=)]
    2021-03-03 misszhang

    谢谢MedSci提供最新的资讯

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=2060722, encodeId=47e02060e22d9, content=<a href='/topic/show?id=48522e070f0' target=_blank style='color:#2F92EE;'>#促性腺激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27070, encryptionId=48522e070f0, topicName=促性腺激素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76d3356, createdName=tongyongming, createdTime=Fri May 28 00:49:05 CST 2021, time=2021-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945505, encodeId=6179945505d0, content=编译能力还有很大的提升空间, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63c65465535, createdName=ms7000001977435667, createdTime=Thu Mar 04 17:41:44 CST 2021, time=2021-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=947423, encodeId=3b7994e4235f, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7af65320876, createdName=148aa736m21暂无昵称, createdTime=Thu Mar 11 15:08:42 CST 2021, time=2021-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1510589, encodeId=283f151058931, content=<a href='/topic/show?id=0032663e6ff' target=_blank style='color:#2F92EE;'>#游离甲状腺素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66376, encryptionId=0032663e6ff, topicName=游离甲状腺素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a0410217579, createdName=xqptu, createdTime=Fri Mar 05 05:49:05 CST 2021, time=2021-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945208, encodeId=b9c59452080c, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210301/28e81c1eda64491ea0507710c5173138/2e20c197213f4d2bb2c03374b04301e6.jpg, createdBy=bfa51746861, createdName=Angela, createdTime=Wed Mar 03 18:01:45 CST 2021, time=2021-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043523, encodeId=aef31043523d1, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Mar 03 17:49:05 CST 2021, time=2021-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945197, encodeId=a36694519e20, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Mar 03 16:59:52 CST 2021, time=2021-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945129, encodeId=6b2a945129f1, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210303/66c17b62a9f144ea8281a5b0894d47e4/c6a5dc1e748547fbb2995fbdb3ecbb88.jpg, createdBy=5dee5415333, createdName=ms7000001038472057, createdTime=Wed Mar 03 14:57:34 CST 2021, time=2021-03-03, status=1, ipAttribution=)]
    2021-03-03 jyzxjiangqin

    好文章!

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2060722, encodeId=47e02060e22d9, content=<a href='/topic/show?id=48522e070f0' target=_blank style='color:#2F92EE;'>#促性腺激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27070, encryptionId=48522e070f0, topicName=促性腺激素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76d3356, createdName=tongyongming, createdTime=Fri May 28 00:49:05 CST 2021, time=2021-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945505, encodeId=6179945505d0, content=编译能力还有很大的提升空间, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63c65465535, createdName=ms7000001977435667, createdTime=Thu Mar 04 17:41:44 CST 2021, time=2021-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=947423, encodeId=3b7994e4235f, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7af65320876, createdName=148aa736m21暂无昵称, createdTime=Thu Mar 11 15:08:42 CST 2021, time=2021-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1510589, encodeId=283f151058931, content=<a href='/topic/show?id=0032663e6ff' target=_blank style='color:#2F92EE;'>#游离甲状腺素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66376, encryptionId=0032663e6ff, topicName=游离甲状腺素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a0410217579, createdName=xqptu, createdTime=Fri Mar 05 05:49:05 CST 2021, time=2021-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945208, encodeId=b9c59452080c, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210301/28e81c1eda64491ea0507710c5173138/2e20c197213f4d2bb2c03374b04301e6.jpg, createdBy=bfa51746861, createdName=Angela, createdTime=Wed Mar 03 18:01:45 CST 2021, time=2021-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043523, encodeId=aef31043523d1, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Mar 03 17:49:05 CST 2021, time=2021-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945197, encodeId=a36694519e20, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Mar 03 16:59:52 CST 2021, time=2021-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=945129, encodeId=6b2a945129f1, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210303/66c17b62a9f144ea8281a5b0894d47e4/c6a5dc1e748547fbb2995fbdb3ecbb88.jpg, createdBy=5dee5415333, createdName=ms7000001038472057, createdTime=Wed Mar 03 14:57:34 CST 2021, time=2021-03-03, status=1, ipAttribution=)]
    2021-03-03 ms7000001038472057

    学习了

    0

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妊娠期糖尿病与早产、极端出生体重儿以及先天异常、死产和新生儿死亡发生率增加相关。本研究旨在确定和比较与1型糖尿病和2型糖尿病女性不良妊娠结局相关的可改变的危险因素。

Clinical Nutrition: 妊娠前三个月孕期维生素D状况与妊娠糖尿病的关系

妊娠糖尿病(GDM)是指在怀孕期间发作的对葡萄糖不耐受的情况,其严重程度可轻可重。

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