Baidu
map

Clinical Nutrition: 妊娠前三个月维生素D状况与妊娠糖尿病之间的关系

2021-01-19 MedSci原创 MedSci原创

妊娠期糖尿病(GDM)是怀孕期间最常见的并发症之一。从长远来看,它与许多不良妊娠,胎儿和新生儿结局以及母亲和儿童的风险增加有关。人们对维生素D及其在代谢性疾病发展中的潜在作用越来越感兴趣。

背景与目标:

妊娠期糖尿病(GDM)是怀孕期间最常见的并发症之一。从长远来看,它与许多不良妊娠,胎儿和新生儿结局以及母亲和儿童的风险增加有关。人们对维生素D及其在代谢性疾病发展中的潜在作用越来越感兴趣。但是,医学文献尚未达成共识。这项研究的目的是根据孕早期的维生素D状况评估GDM的风险。

方法:

这项研究是一项病例对照研究,所有进行25-OH维生素D水平(25OHD)检测的孕妇组成了本项研究的研究对象,总共包括1191名孕妇。将250例患有GDM的妇女(病例)与941例没有GDM的妇女(对照组)进行配对,以确认其胎次,年龄,怀孕前的体重指数,受孕的季节在比较时不存在差异。

结果:

25OHD水平<20 ng / mL的患者,GDM的风险明显更高(OR = 1∙42,95%CI 1∙06–1∙91; p = 0∙021)。但是,与其他变量没有显着关系。对25OHD水平以5个单位间隔进行更精确切割显示出与GDM风险的可变关系:非常低的25OHD水平的发生GDM的风险低,中等水平25OHD则会导致GDM发生风险增加。

结论

妊娠前三个月GDM与25OHD水平之间似乎有线性关系,因为随着25OHD浓度增加,GDM风险会持续降低。

原始出处:

Eleonora Salakos. Et al. Relationship between vitamin D status in the first trimester of pregnancy and gestational diabetes mellitus - A nested case–control study. Clinical Nutrition.2021.

 

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1661621, encodeId=d8a51661621ff, content=<a href='/topic/show?id=1b3c1315481' target=_blank style='color:#2F92EE;'>#nutrition#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13154, encryptionId=1b3c1315481, topicName=nutrition)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f0d25331316, createdName=膀胱癌, createdTime=Wed Oct 27 18:13:51 CST 2021, time=2021-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1946749, encodeId=06be1946e49bc, content=<a href='/topic/show?id=8a0844838ca' target=_blank style='color:#2F92EE;'>#妊娠前#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44838, encryptionId=8a0844838ca, topicName=妊娠前)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38232500109, createdName=1249898am15暂无昵称, createdTime=Thu Jul 15 04:13:51 CST 2021, time=2021-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507740, encodeId=3e6e150e740d1, content=<a href='/topic/show?id=8764484014' target=_blank style='color:#2F92EE;'>#clinical#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4840, encryptionId=8764484014, topicName=clinical)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ee59933733, createdName=zll0628, createdTime=Thu Jan 21 01:13:51 CST 2021, time=2021-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918108, encodeId=0da09181081e, content=<a href='/topic/show?id=27b94491893' target=_blank style='color:#2F92EE;'>#妊娠糖尿病#</a>事实上,仅仅补充<a href='/topic/show?id=5b0fe906618' target=_blank style='color:#2F92EE;'>#维生素D#</a>想见效,并不容易吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=267, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44918, encryptionId=27b94491893, topicName=妊娠糖尿病), TopicDto(id=79066, encryptionId=5b0fe906618, topicName=维生素D)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=lifefamily, createdTime=Tue Jan 19 16:34:12 CST 2021, time=2021-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043475, encodeId=8def10434e5f2, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Tue Jan 19 13:13:51 CST 2021, time=2021-01-19, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1661621, encodeId=d8a51661621ff, content=<a href='/topic/show?id=1b3c1315481' target=_blank style='color:#2F92EE;'>#nutrition#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13154, encryptionId=1b3c1315481, topicName=nutrition)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f0d25331316, createdName=膀胱癌, createdTime=Wed Oct 27 18:13:51 CST 2021, time=2021-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1946749, encodeId=06be1946e49bc, content=<a href='/topic/show?id=8a0844838ca' target=_blank style='color:#2F92EE;'>#妊娠前#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44838, encryptionId=8a0844838ca, topicName=妊娠前)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38232500109, createdName=1249898am15暂无昵称, createdTime=Thu Jul 15 04:13:51 CST 2021, time=2021-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507740, encodeId=3e6e150e740d1, content=<a href='/topic/show?id=8764484014' target=_blank style='color:#2F92EE;'>#clinical#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4840, encryptionId=8764484014, topicName=clinical)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ee59933733, createdName=zll0628, createdTime=Thu Jan 21 01:13:51 CST 2021, time=2021-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918108, encodeId=0da09181081e, content=<a href='/topic/show?id=27b94491893' target=_blank style='color:#2F92EE;'>#妊娠糖尿病#</a>事实上,仅仅补充<a href='/topic/show?id=5b0fe906618' target=_blank style='color:#2F92EE;'>#维生素D#</a>想见效,并不容易吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=267, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44918, encryptionId=27b94491893, topicName=妊娠糖尿病), TopicDto(id=79066, encryptionId=5b0fe906618, topicName=维生素D)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=lifefamily, createdTime=Tue Jan 19 16:34:12 CST 2021, time=2021-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043475, encodeId=8def10434e5f2, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Tue Jan 19 13:13:51 CST 2021, time=2021-01-19, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1661621, encodeId=d8a51661621ff, content=<a href='/topic/show?id=1b3c1315481' target=_blank style='color:#2F92EE;'>#nutrition#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13154, encryptionId=1b3c1315481, topicName=nutrition)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f0d25331316, createdName=膀胱癌, createdTime=Wed Oct 27 18:13:51 CST 2021, time=2021-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1946749, encodeId=06be1946e49bc, content=<a href='/topic/show?id=8a0844838ca' target=_blank style='color:#2F92EE;'>#妊娠前#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44838, encryptionId=8a0844838ca, topicName=妊娠前)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38232500109, createdName=1249898am15暂无昵称, createdTime=Thu Jul 15 04:13:51 CST 2021, time=2021-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507740, encodeId=3e6e150e740d1, content=<a href='/topic/show?id=8764484014' target=_blank style='color:#2F92EE;'>#clinical#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4840, encryptionId=8764484014, topicName=clinical)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ee59933733, createdName=zll0628, createdTime=Thu Jan 21 01:13:51 CST 2021, time=2021-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918108, encodeId=0da09181081e, content=<a href='/topic/show?id=27b94491893' target=_blank style='color:#2F92EE;'>#妊娠糖尿病#</a>事实上,仅仅补充<a href='/topic/show?id=5b0fe906618' target=_blank style='color:#2F92EE;'>#维生素D#</a>想见效,并不容易吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=267, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44918, encryptionId=27b94491893, topicName=妊娠糖尿病), TopicDto(id=79066, encryptionId=5b0fe906618, topicName=维生素D)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=lifefamily, createdTime=Tue Jan 19 16:34:12 CST 2021, time=2021-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043475, encodeId=8def10434e5f2, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Tue Jan 19 13:13:51 CST 2021, time=2021-01-19, status=1, ipAttribution=)]
    2021-01-21 zll0628
  4. [GetPortalCommentsPageByObjectIdResponse(id=1661621, encodeId=d8a51661621ff, content=<a href='/topic/show?id=1b3c1315481' target=_blank style='color:#2F92EE;'>#nutrition#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13154, encryptionId=1b3c1315481, topicName=nutrition)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f0d25331316, createdName=膀胱癌, createdTime=Wed Oct 27 18:13:51 CST 2021, time=2021-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1946749, encodeId=06be1946e49bc, content=<a href='/topic/show?id=8a0844838ca' target=_blank style='color:#2F92EE;'>#妊娠前#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44838, encryptionId=8a0844838ca, topicName=妊娠前)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38232500109, createdName=1249898am15暂无昵称, createdTime=Thu Jul 15 04:13:51 CST 2021, time=2021-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507740, encodeId=3e6e150e740d1, content=<a href='/topic/show?id=8764484014' target=_blank style='color:#2F92EE;'>#clinical#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4840, encryptionId=8764484014, topicName=clinical)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ee59933733, createdName=zll0628, createdTime=Thu Jan 21 01:13:51 CST 2021, time=2021-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918108, encodeId=0da09181081e, content=<a href='/topic/show?id=27b94491893' target=_blank style='color:#2F92EE;'>#妊娠糖尿病#</a>事实上,仅仅补充<a href='/topic/show?id=5b0fe906618' target=_blank style='color:#2F92EE;'>#维生素D#</a>想见效,并不容易吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=267, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44918, encryptionId=27b94491893, topicName=妊娠糖尿病), TopicDto(id=79066, encryptionId=5b0fe906618, topicName=维生素D)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=lifefamily, createdTime=Tue Jan 19 16:34:12 CST 2021, time=2021-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043475, encodeId=8def10434e5f2, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Tue Jan 19 13:13:51 CST 2021, time=2021-01-19, status=1, ipAttribution=)]
    2021-01-19 lifefamily

    #妊娠糖尿病#事实上,仅仅补充#维生素D#想见效,并不容易吧

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1661621, encodeId=d8a51661621ff, content=<a href='/topic/show?id=1b3c1315481' target=_blank style='color:#2F92EE;'>#nutrition#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13154, encryptionId=1b3c1315481, topicName=nutrition)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f0d25331316, createdName=膀胱癌, createdTime=Wed Oct 27 18:13:51 CST 2021, time=2021-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1946749, encodeId=06be1946e49bc, content=<a href='/topic/show?id=8a0844838ca' target=_blank style='color:#2F92EE;'>#妊娠前#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44838, encryptionId=8a0844838ca, topicName=妊娠前)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38232500109, createdName=1249898am15暂无昵称, createdTime=Thu Jul 15 04:13:51 CST 2021, time=2021-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507740, encodeId=3e6e150e740d1, content=<a href='/topic/show?id=8764484014' target=_blank style='color:#2F92EE;'>#clinical#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4840, encryptionId=8764484014, topicName=clinical)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ee59933733, createdName=zll0628, createdTime=Thu Jan 21 01:13:51 CST 2021, time=2021-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918108, encodeId=0da09181081e, content=<a href='/topic/show?id=27b94491893' target=_blank style='color:#2F92EE;'>#妊娠糖尿病#</a>事实上,仅仅补充<a href='/topic/show?id=5b0fe906618' target=_blank style='color:#2F92EE;'>#维生素D#</a>想见效,并不容易吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=267, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44918, encryptionId=27b94491893, topicName=妊娠糖尿病), TopicDto(id=79066, encryptionId=5b0fe906618, topicName=维生素D)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=lifefamily, createdTime=Tue Jan 19 16:34:12 CST 2021, time=2021-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043475, encodeId=8def10434e5f2, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Tue Jan 19 13:13:51 CST 2021, time=2021-01-19, status=1, ipAttribution=)]
    2021-01-19 misszhang

    谢谢MedSci提供最新的资讯

    0

相关资讯

World Allergy Organ J:产前维生素D补充和儿童呼吸道健康:随机对照试验系统回顾和元分析

对母体维生素D状态和呼吸道过敏性疾病风险的观察性研究的系统回顾和元分析表明,母亲在怀孕期间补充维生素D可以降低后代复发性喘息或哮喘的风险。最近,有研究人员进行了随机对照试验的元分析,调查产前补充维生素

Nat Commun:老年人补充维生素D会如何影响肠道微生物组?

其对567名老年男性进行横断面分析,利用LC-MSMS量化血清维生素D代谢物,并从16S核糖体RNA基因测序数据中定义粪便亚操作分类单元。

Clin Nutrition:维生素D缺乏与脑组织健康程度存在关联

有文献已经证实,维生素D缺乏与痴呆症的风险增加有关。

Dig Dis Sci:维生素D缺乏导致结肠局部肾素-血管紧张素系统的激活而加剧结肠炎症

炎性肠病(IBD)是人类胃肠道的慢性疾病,由克罗恩病(CD)和溃疡性结肠炎(UC)组成。

Clin Nutrition: 25(OH)D的生物利用度与弥漫性大B细胞淋巴瘤患者的临床结局相关

我们已经知道,维生素D功能不足与多种癌症类型的临床结局较差有关。然而,其在弥漫性大B细胞淋巴瘤(DLBCL)患者中的作用仍不清楚。

Nat Commun:孟德尔随机化分析评估维生素D与癌症易感性的关联性

维生素D是一种必需的脂溶性维生素,主要是由皮肤暴露于紫外线辐射所产生的。

Baidu
map
Baidu
map
Baidu
map