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PLoS One:免疫逃逸基因在葡萄膜黑色素瘤中的差异调节和预后表征

2019-01-31 MedSci MedSci原创

意大利卡塔尼亚大学生物医学与生物技术科学系的Basile MS和眼科的Russo A等人近日在PLoS One杂志上发表了一篇重要的工作。葡萄膜黑色素瘤(UM)是成人中最常见的原发性眼内癌症。在该项研究中,作者旨在描述原发性UM癌症的免疫学特征,并对预后标志物和治疗结果进行关联分析。此外,他们评估了微环境对UM中抑制性免疫检查点表达的影响。感兴趣的基因包括MHC I类和II类分子以及抑制性免疫检查

意大利卡塔尼亚大学生物医学与生物技术科学系的Basile MS和眼科的Russo A等人近日在PLoS One杂志上发表了一篇重要的工作。葡萄膜黑色素瘤(UM)是成人中最常见的原发性眼内癌症。在该项研究中,作者旨在描述原发性UM癌症的免疫学特征,并对预后标志物和治疗结果进行关联分析。此外,他们评估了微环境对UM中抑制性免疫检查点表达的影响。感兴趣的基因包括MHC I类和II类分子以及抑制性免疫检查点,即PDL1、PDL2、B7-H3、B7-H4、TBFRSF6B、CD47、CD155、GAL9、HVEM和CD200。

与正常葡萄膜黑素细胞相比,他们观察到在UM细胞中,MHC基因的表达水平显着降低。然而,出乎意料的是,与正常黑素细胞相比,在癌细胞中,分析的大多数抑制性免疫检查点基因的表达水平没有差异,只有CD200和HVEM的表达水平显着降低。另一方面,PDL1与OS、PFS和肿瘤厚度之间存在负相关。此外,在炎性条件下,PDL1与PDL2的表达显着增加。最后,他们首次提出,CD47可能在UM的免疫逃避中具有特异性作用。

总之,他们在该研究中显示,CD47在炎症刺激后被UM细胞显着上调,它可以作为疾病进展的良好独立预测因子。此外,该研究的结果可能推动UM患者的免疫疗法发展。

原文出处:

Basile, M.S., et al., Differential modulation and prognostic values of immune-escape genes in uveal melanoma. PLoS One, 2019. 14(1): p. e0210276.

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