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A&R:1990年至2019年特定部位骨关节炎的流行趋势:2019 年全球疾病负担研究的结果

2022-07-24 MedSci原创 MedSci原创

在全球范围内,骨关节炎(OA)的流行病例增加了113.25%,从1990年的2.4751亿增加到2019年的5.2781 亿。OA患病率随着年龄的增长而增加,并揭示出女性主导、地理多样性和解剖部位差异

目的估计系统和解剖部位特定的骨关节炎(OA)年龄标准化患病率(ASR),并分析全球、区域和国家层面OA的长期趋势。

方法数据来自2019年全球疾病负担研究。ASR及其估计的年度百分比变化(EAPC是一种常用的量化手段,用于评估特定时期内ASR的长期趋势,EAPC>0 表示随时间增加,EAPC<0 表示随时间减少。包含095% CIEAPC值表示稳定,或在指定时间段内没有变化)用于根据年龄组、性别、地区、国家和领土以及涉病关节描述OA的长期趋势。根据EAPC和95% CI进行层次聚类分析,对所有 204 个国家和地区进行分类。

结果在全球范围内,OA的流行病例增加了113.25%,从1990年的2.4751亿增加到2019年的5.2781 亿。ASR1990年为6173.3810万人,在2019年为6348.2510万人,年均增加0.12%95%置信区间[ 95% CI] 0.11%, 0.14%)。膝关节(EAPC0.3295% CI 0.29, 0.34))、髋关节(EAPC0.2895% CI 0.26, 0.31))和其他关节OAEAPC0.1895% CI 0.18, 0.19))的ASR增加,但手部的ASR降低(EAPC-0.36 (95% CI -0.38, -0.33))。OA患病率随着年龄的增长而增加,并揭示出女性占主导、地理多样性和解剖部位的差异。膝关节OA对总体负担的贡献最大,而髋关节OA在大多数地区的EAPC最高。

结论:在过去的几十年中,OA一直是全球关注的主要公共卫生问题。OA的患病率随着地理位置和受累关节的不同而增加和多样化。预防和早期治疗对于减轻日益严重的OA负担至关重要。

出处:Long, H., Liu, Q., Yin, H., Wang, K., Diao, N., Zhang, Y., Lin, J. and Guo, A. (2022), Prevalence Trends of Site-Specific Osteoarthritis From 1990 to 2019: Findings From the Global Burden of Disease Study 2019. Arthritis Rheumatol, 74: 1172-1183. https://doi.org/10.1002/art.42089

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    2022-07-23 lmm397
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