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World J Pediatr:口服益生菌能有效改善RRTI患儿肠道微生态平衡,降低RTI发生频率

2020-08-01 MedSci原创 MedSci原创

复发性呼吸道感染(RRTI)是发生在学龄前儿童中的一种常见疾病。

复发性呼吸道感染(RRTI)是发生在学龄前儿童中的一种常见疾病。

将120例RRTI患儿随机分为活动组,缓解组,干预组和对照组,同时选择健康儿童30例作为健康组。干预组患儿口服双歧杆菌四联活菌片(活菌)2个月,对照组接受常规治疗。检测粪便样本,分析细菌菌株。随访1年期间,比较不同组间呼吸道感染(RTI)的发生情况。

结果显示,与健康组相比,活动组、缓解组、干预组和对照组的双歧杆菌和乳酸菌数量明显减少(P<0.05)。干预组的双歧杆菌和乳酸菌数量与其他RRTI组相比明显增加(P<0.05)。随访期间,干预组与对照组相比,不同急性RRTI的年平均发生频率和抗生素使用量均明显减少(P<0.05),干预组每次发作时的平均咳嗽、发热时间和抗生素使用量也明显缩短(P<0.05)。

综上所述,该研究结果表明,RRTI患儿容易出现肠道菌群失调。口服益生菌能有效改善RRTI患儿肠道微生态平衡,降低RTI发生频率。

原始出处:

Ke-Liang LiBen-Zhen Wang, et al., Alterations of intestinal flora and the effects of probiotics in children with recurrent respiratory tract infection. World J Pediatr. 2019 Jun;15(3):255-261. doi: 10.1007/s12519-019-00248-0.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1639568, encodeId=ccb6163956827, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri Feb 19 11:09:30 CST 2021, time=2021-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=908704, encodeId=ea40908e04be, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201216/dbf12fd1b77d4b8e8da0aaf2b1a05175/5eabb5aa9ac84023939f2ffcbea948ba.jpg, createdBy=2fd95325345, createdName=148b9707m67暂无昵称, createdTime=Wed Dec 16 21:35:26 CST 2020, time=2020-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901574, encodeId=866e9015e4d9, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201216/dbf12fd1b77d4b8e8da0aaf2b1a05175/5eabb5aa9ac84023939f2ffcbea948ba.jpg, createdBy=2fd95325345, createdName=148b9707m67暂无昵称, createdTime=Mon Nov 23 21:13:15 CST 2020, time=2020-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1728618, encodeId=ebfe1e28618e6, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu Oct 08 07:09:30 CST 2020, time=2020-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=805532, encodeId=03d080553235, content=<a href='/topic/show?id=5d0ee2249b0' target=_blank style='color:#2F92EE;'>#益生菌#</a>很多阴性结果,这个是阳性结果, beContent=null, objectType=article, channel=null, level=null, likeNumber=233, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72249, encryptionId=5d0ee2249b0, topicName=益生菌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Aug 01 10:19:45 CST 2020, time=2020-08-01, status=1, ipAttribution=)]
    2020-12-16 148b9707m67暂无昵称

    学习

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  3. [GetPortalCommentsPageByObjectIdResponse(id=1639568, encodeId=ccb6163956827, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri Feb 19 11:09:30 CST 2021, time=2021-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=908704, encodeId=ea40908e04be, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201216/dbf12fd1b77d4b8e8da0aaf2b1a05175/5eabb5aa9ac84023939f2ffcbea948ba.jpg, createdBy=2fd95325345, createdName=148b9707m67暂无昵称, createdTime=Wed Dec 16 21:35:26 CST 2020, time=2020-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901574, encodeId=866e9015e4d9, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201216/dbf12fd1b77d4b8e8da0aaf2b1a05175/5eabb5aa9ac84023939f2ffcbea948ba.jpg, createdBy=2fd95325345, createdName=148b9707m67暂无昵称, createdTime=Mon Nov 23 21:13:15 CST 2020, time=2020-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1728618, encodeId=ebfe1e28618e6, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu Oct 08 07:09:30 CST 2020, time=2020-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=805532, encodeId=03d080553235, content=<a href='/topic/show?id=5d0ee2249b0' target=_blank style='color:#2F92EE;'>#益生菌#</a>很多阴性结果,这个是阳性结果, beContent=null, objectType=article, channel=null, level=null, likeNumber=233, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72249, encryptionId=5d0ee2249b0, topicName=益生菌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Aug 01 10:19:45 CST 2020, time=2020-08-01, status=1, ipAttribution=)]
    2020-11-23 148b9707m67暂无昵称

    学习

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  4. [GetPortalCommentsPageByObjectIdResponse(id=1639568, encodeId=ccb6163956827, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri Feb 19 11:09:30 CST 2021, time=2021-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=908704, encodeId=ea40908e04be, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201216/dbf12fd1b77d4b8e8da0aaf2b1a05175/5eabb5aa9ac84023939f2ffcbea948ba.jpg, createdBy=2fd95325345, createdName=148b9707m67暂无昵称, createdTime=Wed Dec 16 21:35:26 CST 2020, time=2020-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901574, encodeId=866e9015e4d9, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201216/dbf12fd1b77d4b8e8da0aaf2b1a05175/5eabb5aa9ac84023939f2ffcbea948ba.jpg, createdBy=2fd95325345, createdName=148b9707m67暂无昵称, createdTime=Mon Nov 23 21:13:15 CST 2020, time=2020-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1728618, encodeId=ebfe1e28618e6, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu Oct 08 07:09:30 CST 2020, time=2020-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=805532, encodeId=03d080553235, content=<a href='/topic/show?id=5d0ee2249b0' target=_blank style='color:#2F92EE;'>#益生菌#</a>很多阴性结果,这个是阳性结果, beContent=null, objectType=article, channel=null, level=null, likeNumber=233, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72249, encryptionId=5d0ee2249b0, topicName=益生菌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Aug 01 10:19:45 CST 2020, time=2020-08-01, status=1, ipAttribution=)]
    2020-10-08 feather89
  5. [GetPortalCommentsPageByObjectIdResponse(id=1639568, encodeId=ccb6163956827, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Fri Feb 19 11:09:30 CST 2021, time=2021-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=908704, encodeId=ea40908e04be, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201216/dbf12fd1b77d4b8e8da0aaf2b1a05175/5eabb5aa9ac84023939f2ffcbea948ba.jpg, createdBy=2fd95325345, createdName=148b9707m67暂无昵称, createdTime=Wed Dec 16 21:35:26 CST 2020, time=2020-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=901574, encodeId=866e9015e4d9, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201216/dbf12fd1b77d4b8e8da0aaf2b1a05175/5eabb5aa9ac84023939f2ffcbea948ba.jpg, createdBy=2fd95325345, createdName=148b9707m67暂无昵称, createdTime=Mon Nov 23 21:13:15 CST 2020, time=2020-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1728618, encodeId=ebfe1e28618e6, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu Oct 08 07:09:30 CST 2020, time=2020-10-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=805532, encodeId=03d080553235, content=<a href='/topic/show?id=5d0ee2249b0' target=_blank style='color:#2F92EE;'>#益生菌#</a>很多阴性结果,这个是阳性结果, beContent=null, objectType=article, channel=null, level=null, likeNumber=233, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72249, encryptionId=5d0ee2249b0, topicName=益生菌)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Aug 01 10:19:45 CST 2020, time=2020-08-01, status=1, ipAttribution=)]
    2020-08-01 lovetcm

    #益生菌#很多阴性结果,这个是阳性结果

    0

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