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Cell:甲状腺癌基因组分析或可帮助寻找恶性肿瘤标记物

2014-10-28 佚名 生物谷

近日,来自美国密歇根大学医学院的研究人员通过对甲状腺癌进行研究鉴别出了恶性肿瘤的标记物,其或许可以帮助开发治疗癌症的个体化靶向疗法,相关研究刊登于国际杂志Cell上。 文章中,研究者Thomas J. Giordano表示,对甲状腺癌基因组蓝图的理解将会进一步帮助其进行精确分类及改善分子诊断技术,同时也可以帮助我们分离出那些需要进行积极治疗的病人。甲状腺癌的发病率在过去30年增加了3倍,而且

近日,来自美国密歇根大学医学院的研究人员通过对甲状腺癌进行研究鉴别出了恶性肿瘤的标记物,其或许可以帮助开发治疗癌症的个体化靶向疗法,相关研究刊登于国际杂志Cell上。

文章中,研究者Thomas J. Giordano表示,对甲状腺癌基因组蓝图的理解将会进一步帮助其进行精确分类及改善分子诊断技术,同时也可以帮助我们分离出那些需要进行积极治疗的病人。甲状腺癌的发病率在过去30年增加了3倍,而且其在美国是一种增长速度比较快的癌症,甲状腺肿瘤通常生长缓慢,而且很容易通过外科手术、甲状腺激素及放射性碘联合疗法进行治疗,但是仍有一些病人会发展成为恶性甚至是致死性的甲状腺癌。

这项研究中,研究人员分析了约500份甲状腺癌样本来鉴别引发癌症的遗传突变,结果发现了许多新型的癌症基因及现有致癌基因的新型突变。甲状腺癌的基因组相对稳定,相比其它癌症来讲其携带的遗传突变很少,这也正可以解释为何甲状腺癌进展比较缓慢。新型突变的产生就意味着研究人员需要研究其介导的信号路径及其驱动甲状腺癌的分子机制。

研究者Getz表示,本文研究整合了多种基因组数据,其不仅可以鉴别出驱动癌症发生的驱动子,而且可以对比不同驱动因素的行为差别;更有意思的是我们发现了BRAF突变的甲状腺癌亚群可以通过特殊的机制来引发癌症,而且某些甲状腺癌亚群和某些高风险、低分化的癌症风险直接相关。

如今研究人员就可利用甲状腺癌基因组的数据开发一些新型策略来确定肿瘤信号产生的原因及甲状腺癌的发展程度;本文研究或许可以帮助医生和病人对甲状腺癌进行精确的诊断及开发新型靶向疗法来治疗甲状腺癌。

原始出处

The Cancer Genome Atlas Research Network .Integrated Genomic Characterization of Papillary Thyroid Carcinoma.Cell.2014

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    2016-03-22 Gsurgeon

    希望有启发

    0

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    2015-03-25 wjywjy
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    2015-05-21 jasonuclear

    希望能有所启发!

    0

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  6. [GetPortalCommentsPageByObjectIdResponse(id=72492, encodeId=161ae2492d2, content=希望有启发, beContent=null, objectType=article, channel=null, level=null, likeNumber=202, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a6a1604604, createdName=Gsurgeon, createdTime=Tue Mar 22 00:05:00 CST 2016, time=2016-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1904425, encodeId=1fa119044257e, content=<a href='/topic/show?id=b8aa619690e' target=_blank style='color:#2F92EE;'>#标记物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61969, encryptionId=b8aa619690e, topicName=标记物)], attachment=null, authenticateStatus=null, createdAvatar=/img/user_icon.png, createdBy=1072181, createdName=wjywjy, createdTime=Wed Mar 25 17:07:00 CST 2015, time=2015-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=24388, encodeId=280624388cf, content=希望能有所启发!, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160515/IMG57380B859AD1F1019.jpg, createdBy=2c5c1621956, createdName=jasonuclear, createdTime=Thu May 21 12:17:00 CST 2015, time=2015-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1931819, encodeId=cc1d1931819c3, content=<a href='/topic/show?id=7b6c829e4b8' target=_blank style='color:#2F92EE;'>#肿瘤标记物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82974, encryptionId=7b6c829e4b8, topicName=肿瘤标记物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e07307, createdName=lingaifan, createdTime=Tue Aug 25 09:07:00 CST 2015, time=2015-08-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1868930, encodeId=53ce18689300b, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Fri May 29 17:07:00 CST 2015, time=2015-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959176, encodeId=d90a19591e6e7, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Thu Jun 04 16:07:00 CST 2015, time=2015-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1736135, encodeId=3c851e3613596, content=<a href='/topic/show?id=e5504182238' target=_blank style='color:#2F92EE;'>#基因组分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41822, encryptionId=e5504182238, topicName=基因组分析)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Dec 01 23:07:00 CST 2014, time=2014-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1373871, encodeId=67e613e3871ea, content=<a href='/topic/show?id=3644e1286f1' target=_blank style='color:#2F92EE;'>#癌基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71286, encryptionId=3644e1286f1, topicName=癌基因)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ee7b365, createdName=zhucaizhong7766, createdTime=Thu Oct 30 00:07:00 CST 2014, time=2014-10-30, status=1, ipAttribution=)]
    2015-06-04 维他命
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