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Rheumatology:超重女性膝骨关节炎:生活方式干预和硫酸氨基葡萄糖治疗有用吗?

2017-08-31 王立群 环球医学

2017年8月,发表了《Rheumatology》的一项研究调查了生活方式干预和口服硫酸氨基葡萄糖对基线无膝骨关节炎(OA)、中年超重女性6~7年后膝OA发病率的影响。



2017年8月,发表了《Rheumatology》的一项研究调查了生活方式干预和口服硫酸氨基葡萄糖对基线无膝骨关节炎(OA)、中年超重女性6~7年后膝OA发病率的影响。

目标:本研究评估旨在减重的生活方式干预和口服硫酸氨基葡萄糖对基线无膝OA、中年超重女性6~7年后膝OA发病率的影响。

方法:超重女性膝骨关节炎的预防研究ISRCTN42823086是一项2×2析因设计的随机对照试验。407例50~60岁、BMI≥27 kg/m2、无膝OA的女性被随机分配。

结果:平均随访6.6年之后,获得来自245例患者中的477个膝盖数据。其中19%发生膝OA。两种干预措施对膝OA的发生均无显着预防作用。尽管实际上每个协议分析都显示两组之间的生活方式干预有较大的差异,但没有达到显着性。根据主要结局发现在最初12个月内,减少体重≥5kg或≥5%的基线体重对膝OA发生率有显着影响(比值比=0.10;95%CI:0.02,0.41)。

结论:生活方式干预或硫酸氨基葡萄糖干预均对膝OA事件没有显着的预防作用。作为一个概念验证,证明了1年内适度体重减轻对临床膝OA发生率有预防作用。这项试验提供了今后关于预防膝OA的研究的重要见解,其正是当前所缺少的。

原始出处:

Bastiaan C. de Vos, et al. Long-term effects of a lifestyle intervention and oral glucosamine sulphate in primary care on incident knee OA in overweight women. Rheumatology, Volume 56, Issue 8, 1 August 2017, Pages 1326–1334.

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    2018-02-06 lisa438
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    2017-09-02 lmm397
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    2017-09-01 hfuym10906

    学习了学习了学习了学习了学习了学习了学习了学习了学习了

    0

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    2017-09-01 龙胆草

    学习谢谢分享

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    2017-08-31 楠博One

    为中老年妇女的常见病

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