Baidu
map

Diabetologia:产妇妊娠期糖尿病或与后代认知下降有关

2013-12-23 佚名 丁香园

研究要点: 1.该研究探讨产妇妊娠期糖尿病与后代认知能力的关系; 2.发现产妇妊娠期糖尿病或与后代认知下降有关; 3.这种相关性可以通过共同的家族特征来解释。 为了探讨产妇妊娠期糖尿病与后代认知能力的关系,并评估这种相关性是否由宫内机制或共同的家族特征引起,来自英国布里斯托大学的Abigail Fraser教授及其团队进行了一项研究,该研究发现产妇妊

研究要点:

1.该研究探讨产妇妊娠期糖尿病与后代认知能力的关系;

2.发现产妇妊娠期糖尿病或与后代认知下降有关;

3.这种相关性可以通过共同的家族特征来解释。

为了探讨产妇妊娠期糖尿病与后代认知能力的关系,并评估这种相关性是否由宫内机制或共同的家族特征引起,来自英国布里斯托大学的Abigail Fraser教授及其团队进行了一项研究,该研究发现产妇妊娠期糖尿病或与后代认知下降有关,这种相关性可以通过共同的家族特征来解释。该研究结果在线发表在2013年09月25日的Diabetologia杂志上。 【原文下载】

该研究小组联合瑞典国家登记处对瑞典出生的单胎男婴进行一相前瞻性队列研究,探讨产妇妊娠期糖尿病与后代16岁时教育成就、完成瑞典义务教育的年龄和18岁强制征兵检查时的智商的关系。

该研究结果表明,即使在矫正产妇生产年龄、产次、受教育程度、孕前BMI、后代出生年份、胎龄和出生体重后,产妇妊娠期糖尿病也与后代(无血缘关系)认知能力降低有关。例如,妊娠期有糖尿病的母亲生下男孩智商比没有糖尿病母亲生下的男孩平均低1.36分。相比之下,有血缘关系的男孩中未发现这种相关性。

该研究发现,产妇妊娠期糖尿病与后代认知结局的关系可以通过共同的家族特征,而不是宫内机制来解释。

研究背景:

很多研究比较妊娠期有糖尿病母亲后代与妊娠期没有糖尿病母亲后代的认知指标,发现西方人群中,糖尿病母亲的后代某些认知指标评分下降,但总的智商没有下降。使用瑞典人口登记数据进行的最大流行病学研究发现产妇妊娠糖尿病与后代16岁时教育成就下降有关。

原文出处:

Fraser A, Almqvist C, Larsson H, Långström N, Lawlor DA.Maternal diabetes in pregnancy and offspring cognitive ability: sibling study with 723,775 men from 579,857 families.Diabetologia. 2014 Jan;57(1):102-9. doi: 10.1007/s00125-013-3065-z.Epub 2013 Sep 25. 【原文下载】

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1636780, encodeId=6e391636e8033, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Feb 01 07:09:00 CST 2014, time=2014-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2028583, encodeId=3a7a202858334, content=<a href='/topic/show?id=bc58912088f' target=_blank style='color:#2F92EE;'>#认知下降#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91208, encryptionId=bc58912088f, topicName=认知下降)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Tue Jan 14 04:09:00 CST 2014, time=2014-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759379, encodeId=103b1e59379fe, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Wed Jan 15 20:09:00 CST 2014, time=2014-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250930, encodeId=bfb212509307f, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Wed Dec 25 05:09:00 CST 2013, time=2013-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1253571, encodeId=26f412535e136, content=<a href='/topic/show?id=9d5d44888a9' target=_blank style='color:#2F92EE;'>#妊娠期糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44888, encryptionId=9d5d44888a9, topicName=妊娠期糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Wed Dec 25 05:09:00 CST 2013, time=2013-12-25, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1636780, encodeId=6e391636e8033, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Feb 01 07:09:00 CST 2014, time=2014-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2028583, encodeId=3a7a202858334, content=<a href='/topic/show?id=bc58912088f' target=_blank style='color:#2F92EE;'>#认知下降#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91208, encryptionId=bc58912088f, topicName=认知下降)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Tue Jan 14 04:09:00 CST 2014, time=2014-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759379, encodeId=103b1e59379fe, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Wed Jan 15 20:09:00 CST 2014, time=2014-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250930, encodeId=bfb212509307f, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Wed Dec 25 05:09:00 CST 2013, time=2013-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1253571, encodeId=26f412535e136, content=<a href='/topic/show?id=9d5d44888a9' target=_blank style='color:#2F92EE;'>#妊娠期糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44888, encryptionId=9d5d44888a9, topicName=妊娠期糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Wed Dec 25 05:09:00 CST 2013, time=2013-12-25, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1636780, encodeId=6e391636e8033, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Feb 01 07:09:00 CST 2014, time=2014-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2028583, encodeId=3a7a202858334, content=<a href='/topic/show?id=bc58912088f' target=_blank style='color:#2F92EE;'>#认知下降#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91208, encryptionId=bc58912088f, topicName=认知下降)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Tue Jan 14 04:09:00 CST 2014, time=2014-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759379, encodeId=103b1e59379fe, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Wed Jan 15 20:09:00 CST 2014, time=2014-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250930, encodeId=bfb212509307f, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Wed Dec 25 05:09:00 CST 2013, time=2013-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1253571, encodeId=26f412535e136, content=<a href='/topic/show?id=9d5d44888a9' target=_blank style='color:#2F92EE;'>#妊娠期糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44888, encryptionId=9d5d44888a9, topicName=妊娠期糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Wed Dec 25 05:09:00 CST 2013, time=2013-12-25, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1636780, encodeId=6e391636e8033, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Feb 01 07:09:00 CST 2014, time=2014-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2028583, encodeId=3a7a202858334, content=<a href='/topic/show?id=bc58912088f' target=_blank style='color:#2F92EE;'>#认知下降#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91208, encryptionId=bc58912088f, topicName=认知下降)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Tue Jan 14 04:09:00 CST 2014, time=2014-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759379, encodeId=103b1e59379fe, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Wed Jan 15 20:09:00 CST 2014, time=2014-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250930, encodeId=bfb212509307f, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Wed Dec 25 05:09:00 CST 2013, time=2013-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1253571, encodeId=26f412535e136, content=<a href='/topic/show?id=9d5d44888a9' target=_blank style='color:#2F92EE;'>#妊娠期糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44888, encryptionId=9d5d44888a9, topicName=妊娠期糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Wed Dec 25 05:09:00 CST 2013, time=2013-12-25, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1636780, encodeId=6e391636e8033, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat Feb 01 07:09:00 CST 2014, time=2014-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2028583, encodeId=3a7a202858334, content=<a href='/topic/show?id=bc58912088f' target=_blank style='color:#2F92EE;'>#认知下降#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91208, encryptionId=bc58912088f, topicName=认知下降)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Tue Jan 14 04:09:00 CST 2014, time=2014-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1759379, encodeId=103b1e59379fe, content=<a href='/topic/show?id=9bea33520d' target=_blank style='color:#2F92EE;'>#BET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3352, encryptionId=9bea33520d, topicName=BET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a1a37427546, createdName=ms5439512287675881, createdTime=Wed Jan 15 20:09:00 CST 2014, time=2014-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250930, encodeId=bfb212509307f, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Wed Dec 25 05:09:00 CST 2013, time=2013-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1253571, encodeId=26f412535e136, content=<a href='/topic/show?id=9d5d44888a9' target=_blank style='color:#2F92EE;'>#妊娠期糖尿病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44888, encryptionId=9d5d44888a9, topicName=妊娠期糖尿病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Wed Dec 25 05:09:00 CST 2013, time=2013-12-25, status=1, ipAttribution=)]

相关资讯

美国妊娠期糖尿病新指南仍力挺两步筛查法

近期,美国妇产科医师学会(ACOG)更新妊娠期糖尿病(GDM)治疗指南,仍建议用两步法来诊断GDM。(Obstet Gynecol.2013,122:406) GDM两步诊断法是指:妊娠24~28周先做50g葡萄糖负荷试验进行初步筛查,即口服50g葡萄糖,1h后抽血化验血糖,血糖水平≥7.8mmol/L为异常;异常者需进一步行100g糖耐量试验(OGTT)进行确诊,分别测定空腹血糖(FBG)及负

WHO:全世界有3.47亿人患有糖尿病

  重要事实全世界有3.47亿人患有糖尿病。2004年,估计有340万人死于高血糖引起的后果。超过80%的糖尿病死亡发生在低收入和中等收入国家。据世卫组织预测,2005至2030年期间糖尿病死亡数将增加一倍。健康饮食、经常锻炼身体、保持正常体重和避免使用烟草,可预防或推迟二型糖尿病发病。什么是糖尿病?   糖尿病是一种慢性疾病,当胰腺产生不了足够的胰岛素或者人体无法有效地利用所产生的胰岛素时,就

Diabetes Care:低碳饮食对妊娠期糖尿病无效

  根据《Diabetes Care》4月5日在线发表的一项研究结果,较少热量来自碳水化合物的饮食并不能减少妊娠期糖尿病患者对胰岛素治疗的需求,也不影响妊娠结局。   高级作者、西班牙Lleida大学的Didac Mauricio博士指出:“我们应当开始反思膳食糖负荷在妊娠期糖尿病治疗中的角色。而且,需要进一步研究妊娠期糖尿病的医学营养治疗(MNT)。”MNT是妊娠期糖尿病治疗的支柱,而且是以控

Diabetes Care:低碳饮食对妊娠期糖尿病无效

  根据Diabetes Care 4月5日在线发表的一项研究结果,较少热量来自碳水化合物的饮食并不能减少妊娠期糖尿病患者对胰岛素治疗的需求,也不影响妊娠结局。   高级作者、西班牙Lleida大学的Didac Mauricio博士指出:“我们应当开始反思膳食糖负荷在妊娠期糖尿病治疗中的角色。而且,需要进一步研究妊娠期糖尿病的医学营养治疗(MNT)。”MNT是妊娠期糖尿病治疗的支柱,而且是以控制

2013 NIH 妊娠期糖尿病(GDM)诊断声明

    3月6日,美国国立卫生研究院(NIH)发布妊娠期糖尿病(GDM)诊断声明,建议诊断GDM仍需分两步走:先做50 g葡萄糖负荷试验进行初步筛查,即口服50 g葡萄糖,1 h后抽血化验血糖,若血糖水平≥7.8 mmol/L为异常,异常者需进一步做75 g或者100 g糖耐量试验(OGTT)进行确诊,测定空腹血糖(FBG)、1 h、2 h和3 h的血糖水平,正常值分

Diabetes Care:初次产检血糖不宜确诊妊娠期糖尿病

  北京大学第一医院杨慧霞教授等报告,孕妇初次产检时空腹血糖(FPG) 水平≥5.10mmol/L 不能确诊为妊娠期糖尿病(GDM)。若6.10 mmol/L ≤初次产检时FPG 水平<7.00 mmol/L,则应视作GDM 并给予营养和运动干预;当FPG 水平处5.10~6.09mmol/L 时, 也可适当加强营养和锻炼,同时在妊娠24~28 周时进行口服葡萄糖耐量试验(OGTT), 以排

Baidu
map
Baidu
map
Baidu
map