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2016美国感染病协会:更新曲霉菌感染临床实践指南

2016-07-02 MedSci MedSci原创

美国感染病学会近期更新了曲霉菌的诊断和管理临床实践指南,提倡使用更加具有耐受性的抗真菌药物,并建议内科医师在诊断时更加积极主动。

美国感染病协会近期更新了曲霉菌的诊断和管理临床实践指南,提倡使用更加具有耐受性的抗真菌药物,并建议内科医师在诊断时更加积极主动。

德克萨斯大学医学科学中心感染科教授Thomas F. Patterson博士指出:“侵袭性曲霉菌病经常被忽略,早期的诊断和治疗是关键。这是一种复杂的感染,有多种治疗方案。患者将从多学科的管理方法中获益,包括参考感染科专家的意见。”

此次指南更新自2008年的版本,由17位专家组成的多学科小组收集了近期发表的关于过敏反应,慢性侵袭性曲霉菌感染的文献。经过10个月的讨论,使用GRADE评估系统将证据分为“弱”或“强”。根据两位外部同行评议专家的反馈,发表了指南并由儿科感染协会支持和IDSA临床实践指南委员会批准。

主要更新包括:倾向于Cresemba(艾沙康唑硫酸酯,安斯泰来),Noxafil(泊沙康唑,默克)或伏立康唑/棘白霉素联合治疗,取决于患者的风险大小。除此之外,小组建议,优先使用抗真菌药物,或使用感染风险评估系统对患者进行筛查,如那些住院和免疫抑制的患者。另外,要加强对曲霉菌病的检测,包括侵入性检查手段的使用。


尽管临床水平的进步,Patterson 和他的同事写到:“对此类感染性疾病的管理仍存在重要的知识欠缺,包括最佳的联合治疗方案,早期诊断工具,对治疗反应的评估,爆发性和难治性感染的治疗,以及将从预防中获益最大的患者群体。”

指南全文下载:2016IDSA:曲霉菌感染临床实践指南 (下载梅斯医学APP,也可以直接下载大量指南)

原始出处:

Patterson TF, et al. IDSA updates aspergillosis clinical practice guidelines,Clin Infect Dis. 2016;doi:10.1093/cid/ciw326.

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    2016-08-10 cocoyan

    为啥下载了看不见?

    0

  3. 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createdTime=Mon Jul 04 05:34:00 CST 2016, time=2016-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570790, encodeId=b02d15e0790f1, content=<a href='/topic/show?id=1e296025e18' target=_blank style='color:#2F92EE;'>#曲霉菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60257, encryptionId=1e296025e18, topicName=曲霉菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d77115715468, createdName=fzwish20005, createdTime=Mon Jul 04 05:34:00 CST 2016, time=2016-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571938, encodeId=1b7415e193886, content=<a href='/topic/show?id=413922e74cd' target=_blank style='color:#2F92EE;'>#临床实践指南#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22774, encryptionId=413922e74cd, topicName=临床实践指南)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=276d15780972, createdName=lily1621, createdTime=Mon Jul 04 05:34:00 CST 2016, time=2016-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1604319, encodeId=d7cd1604319f4, content=<a href='/topic/show?id=71b95335396' target=_blank style='color:#2F92EE;'>#感染病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53353, encryptionId=71b95335396, topicName=感染病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=337119178396, createdName=xugc, createdTime=Mon Jul 04 05:34:00 CST 2016, time=2016-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91818, encodeId=26bd918182a, content=真菌感染很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b3781729882, createdName=WEIXINa82df6bc, createdTime=Sun Jul 03 08:58:00 CST 2016, time=2016-07-03, status=1, ipAttribution=)]
    2016-07-05 zybear

    好东西!

    0

  5. 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CST 2016, time=2016-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91920, encodeId=d2569192037, content=好好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151110/IMG5641A6F12C0732294.jpg, createdBy=2f901662448, createdName=乐奕11, createdTime=Mon Jul 04 23:14:00 CST 2016, time=2016-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323622, encodeId=f6e013236222f, content=<a href='/topic/show?id=42b922e7350' target=_blank style='color:#2F92EE;'>#临床实践#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22773, encryptionId=42b922e7350, topicName=临床实践)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Mon Jul 04 05:34:00 CST 2016, time=2016-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570790, encodeId=b02d15e0790f1, content=<a href='/topic/show?id=1e296025e18' target=_blank style='color:#2F92EE;'>#曲霉菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60257, encryptionId=1e296025e18, topicName=曲霉菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d77115715468, createdName=fzwish20005, createdTime=Mon Jul 04 05:34:00 CST 2016, time=2016-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571938, encodeId=1b7415e193886, content=<a href='/topic/show?id=413922e74cd' target=_blank style='color:#2F92EE;'>#临床实践指南#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22774, encryptionId=413922e74cd, topicName=临床实践指南)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=276d15780972, createdName=lily1621, createdTime=Mon Jul 04 05:34:00 CST 2016, time=2016-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1604319, encodeId=d7cd1604319f4, content=<a href='/topic/show?id=71b95335396' target=_blank style='color:#2F92EE;'>#感染病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53353, encryptionId=71b95335396, topicName=感染病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=337119178396, createdName=xugc, createdTime=Mon Jul 04 05:34:00 CST 2016, time=2016-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91818, encodeId=26bd918182a, content=真菌感染很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b3781729882, createdName=WEIXINa82df6bc, createdTime=Sun Jul 03 08:58:00 CST 2016, time=2016-07-03, status=1, ipAttribution=)]
    2016-07-04 乐奕11

    好好的

    0

  6. 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attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b3781729882, createdName=WEIXINa82df6bc, createdTime=Sun Jul 03 08:58:00 CST 2016, time=2016-07-03, status=1, ipAttribution=)]
  7. 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  8. 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createdTime=Mon Jul 04 05:34:00 CST 2016, time=2016-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570790, encodeId=b02d15e0790f1, content=<a href='/topic/show?id=1e296025e18' target=_blank style='color:#2F92EE;'>#曲霉菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60257, encryptionId=1e296025e18, topicName=曲霉菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d77115715468, createdName=fzwish20005, createdTime=Mon Jul 04 05:34:00 CST 2016, time=2016-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571938, encodeId=1b7415e193886, content=<a href='/topic/show?id=413922e74cd' target=_blank style='color:#2F92EE;'>#临床实践指南#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22774, encryptionId=413922e74cd, 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attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b3781729882, createdName=WEIXINa82df6bc, createdTime=Sun Jul 03 08:58:00 CST 2016, time=2016-07-03, status=1, ipAttribution=)]
  9. [GetPortalCommentsPageByObjectIdResponse(id=2030991, encodeId=0587203099148, content=<a href='/topic/show?id=5df2460e269' target=_blank style='color:#2F92EE;'>#实践指南#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46072, encryptionId=5df2460e269, topicName=实践指南)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=796422, createdName=lvliquan, createdTime=Thu Jun 01 07:34:00 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97272, encodeId=b7aa9e27209, content=为啥下载了看不见?, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=95d71609171, createdName=cocoyan, createdTime=Wed Aug 10 14:03:00 CST 2016, time=2016-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1723826, encodeId=c0d01e23826e8, content=<a href='/topic/show?id=36ea988949a' target=_blank style='color:#2F92EE;'>#霉菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98894, encryptionId=36ea988949a, topicName=霉菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sun Jan 15 13:34:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91935, encodeId=e73c9193515, content=好东西!, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210720/81c525def1c4490db2c4d4fd31f4b910/367559b074d146aeab71188669c2396a.jpg, createdBy=3ec21628724, createdName=zybear, createdTime=Tue Jul 05 06:21:00 CST 2016, time=2016-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91920, encodeId=d2569192037, content=好好的, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20151110/IMG5641A6F12C0732294.jpg, createdBy=2f901662448, createdName=乐奕11, createdTime=Mon Jul 04 23:14:00 CST 2016, time=2016-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1323622, encodeId=f6e013236222f, content=<a href='/topic/show?id=42b922e7350' target=_blank style='color:#2F92EE;'>#临床实践#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22773, encryptionId=42b922e7350, topicName=临床实践)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Mon Jul 04 05:34:00 CST 2016, time=2016-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570790, encodeId=b02d15e0790f1, content=<a href='/topic/show?id=1e296025e18' target=_blank style='color:#2F92EE;'>#曲霉菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60257, encryptionId=1e296025e18, topicName=曲霉菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d77115715468, createdName=fzwish20005, createdTime=Mon Jul 04 05:34:00 CST 2016, time=2016-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571938, encodeId=1b7415e193886, content=<a href='/topic/show?id=413922e74cd' target=_blank style='color:#2F92EE;'>#临床实践指南#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22774, encryptionId=413922e74cd, topicName=临床实践指南)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=276d15780972, createdName=lily1621, createdTime=Mon Jul 04 05:34:00 CST 2016, time=2016-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1604319, encodeId=d7cd1604319f4, content=<a href='/topic/show?id=71b95335396' target=_blank style='color:#2F92EE;'>#感染病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53353, encryptionId=71b95335396, topicName=感染病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=337119178396, createdName=xugc, createdTime=Mon Jul 04 05:34:00 CST 2016, time=2016-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91818, encodeId=26bd918182a, content=真菌感染很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b3781729882, createdName=WEIXINa82df6bc, createdTime=Sun Jul 03 08:58:00 CST 2016, time=2016-07-03, status=1, ipAttribution=)]
    2016-07-04 xugc
  10. [GetPortalCommentsPageByObjectIdResponse(id=2030991, encodeId=0587203099148, content=<a href='/topic/show?id=5df2460e269' target=_blank style='color:#2F92EE;'>#实践指南#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46072, encryptionId=5df2460e269, topicName=实践指南)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=796422, createdName=lvliquan, createdTime=Thu Jun 01 07:34:00 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=97272, encodeId=b7aa9e27209, content=为啥下载了看不见?, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=95d71609171, createdName=cocoyan, createdTime=Wed Aug 10 14:03:00 CST 2016, time=2016-08-10, status=1, ipAttribution=), 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topicName=临床实践指南)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=276d15780972, createdName=lily1621, createdTime=Mon Jul 04 05:34:00 CST 2016, time=2016-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1604319, encodeId=d7cd1604319f4, content=<a href='/topic/show?id=71b95335396' target=_blank style='color:#2F92EE;'>#感染病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53353, encryptionId=71b95335396, topicName=感染病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=337119178396, createdName=xugc, createdTime=Mon Jul 04 05:34:00 CST 2016, time=2016-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91818, encodeId=26bd918182a, content=真菌感染很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b3781729882, createdName=WEIXINa82df6bc, createdTime=Sun Jul 03 08:58:00 CST 2016, time=2016-07-03, status=1, ipAttribution=)]
    2016-07-03 WEIXINa82df6bc

    真菌感染很多

    0

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