Baidu
map

Science:成像技术活体监测HIV的扩散过程

2015-10-10 佚名 生物谷

逆转录病毒(比如HIV)如何在宿主中进行扩散,目前科学家们并不清楚,近日,来自耶鲁大学的研究人员通过研究设计了一种方法,可以在活的有机体中实现对HIV扩散过程的观察,相关研究刊登在了国际杂志Science上,文章中研究者成功观察到了HIV如何到达并且在小鼠淋巴结中实现扩散的过程。研究者Walther Mothes教授说道,我们所观察到的病毒的扩散方式和人们想象中并不相同,实验中我们对小鼠机体中荧光

逆转录病毒(比如HIV)如何在宿主中进行扩散,目前科学家们并不清楚,近日,来自耶鲁大学的研究人员通过研究设计了一种方法,可以在活的有机体中实现对HIV扩散过程的观察,相关研究刊登在了国际杂志Science上,文章中研究者成功观察到了HIV如何到达并且在小鼠淋巴结中实现扩散的过程。

研究者Walther Mothes教授说道,我们所观察到的病毒的扩散方式和人们想象中并不相同,实验中我们对小鼠机体中荧光标记的病毒进行追踪,利用复杂的成像技术来捕捉病毒颗粒结合巨噬细胞的过程,这一结合过程是通过位于淋巴结表面的粘性蛋白来完成的。

研究者表示,捕获的病毒颗粒可以向一种罕见类型的B细胞开放,随后病毒颗粒就会将自身吸附于这些B细胞的尾部,并且被拖入淋巴结内部,在一至两天内这些B细胞就会同组织建立稳定的联系,从而促进病毒的完全传递。研究者所拍摄的视频中就描述了一种潜在的途径来帮助抑制HIV感染患处周围的组织,如果研究人员可以开发出一种阻断HIV利用粘性蛋白来结合巨噬细胞的方法,那么病毒的扩散传播就会被抑制。

Mothes说道,对活体动物机体中病毒的发病机制进行直接研究或可帮助揭示很多新的现象和机制。目前我们仍然投入了大量的精力进行相关研究,希望通过后期的研究可以更清楚地解析HIV感染宿主并且在宿主机体中扩散的机制,同时也为开发新型抵御HIV感染的新型疗法提供一定帮助和思路。

原始出处:

Xaver Sewald et al.Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection.Science.Oct 1, 2015.DOI: 10.1126/science.aab2749

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2079105, encodeId=eeea20e910562, content=<a href='/topic/show?id=caa55488ea4' target=_blank style='color:#2F92EE;'>#技术活#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54887, encryptionId=caa55488ea4, topicName=技术活)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=54f9127, createdName=tulenzi, createdTime=Mon Dec 21 06:05:00 CST 2015, time=2015-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375098, encodeId=0b0013e509854, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Mon Oct 12 00:05:00 CST 2015, time=2015-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570733, encodeId=820615e073320, content=<a href='/topic/show?id=03d55395183' target=_blank style='color:#2F92EE;'>#成像技术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53951, encryptionId=03d55395183, topicName=成像技术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d6b515702368, createdName=photoman, createdTime=Mon Oct 12 00:05:00 CST 2015, time=2015-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38354, encodeId=b53438354ee, content=感谢作者分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Sun Oct 11 17:32:00 CST 2015, time=2015-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38283, encodeId=669d38283f8, content=动态成像发展迅速, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Oct 10 17:49:00 CST 2015, time=2015-10-10, status=1, ipAttribution=)]
    2015-12-21 tulenzi
  2. [GetPortalCommentsPageByObjectIdResponse(id=2079105, encodeId=eeea20e910562, content=<a href='/topic/show?id=caa55488ea4' target=_blank style='color:#2F92EE;'>#技术活#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54887, encryptionId=caa55488ea4, topicName=技术活)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=54f9127, createdName=tulenzi, createdTime=Mon Dec 21 06:05:00 CST 2015, time=2015-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375098, encodeId=0b0013e509854, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Mon Oct 12 00:05:00 CST 2015, time=2015-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570733, encodeId=820615e073320, content=<a href='/topic/show?id=03d55395183' target=_blank style='color:#2F92EE;'>#成像技术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53951, encryptionId=03d55395183, topicName=成像技术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d6b515702368, createdName=photoman, createdTime=Mon Oct 12 00:05:00 CST 2015, time=2015-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38354, encodeId=b53438354ee, content=感谢作者分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Sun Oct 11 17:32:00 CST 2015, time=2015-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38283, encodeId=669d38283f8, content=动态成像发展迅速, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Oct 10 17:49:00 CST 2015, time=2015-10-10, status=1, ipAttribution=)]
    2015-10-12 jichang
  3. [GetPortalCommentsPageByObjectIdResponse(id=2079105, encodeId=eeea20e910562, content=<a href='/topic/show?id=caa55488ea4' target=_blank style='color:#2F92EE;'>#技术活#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54887, encryptionId=caa55488ea4, topicName=技术活)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=54f9127, createdName=tulenzi, createdTime=Mon Dec 21 06:05:00 CST 2015, time=2015-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375098, encodeId=0b0013e509854, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Mon Oct 12 00:05:00 CST 2015, time=2015-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570733, encodeId=820615e073320, content=<a href='/topic/show?id=03d55395183' target=_blank style='color:#2F92EE;'>#成像技术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53951, encryptionId=03d55395183, topicName=成像技术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d6b515702368, createdName=photoman, createdTime=Mon Oct 12 00:05:00 CST 2015, time=2015-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38354, encodeId=b53438354ee, content=感谢作者分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Sun Oct 11 17:32:00 CST 2015, time=2015-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38283, encodeId=669d38283f8, content=动态成像发展迅速, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Oct 10 17:49:00 CST 2015, time=2015-10-10, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=2079105, encodeId=eeea20e910562, content=<a href='/topic/show?id=caa55488ea4' target=_blank style='color:#2F92EE;'>#技术活#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54887, encryptionId=caa55488ea4, topicName=技术活)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=54f9127, createdName=tulenzi, createdTime=Mon Dec 21 06:05:00 CST 2015, time=2015-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375098, encodeId=0b0013e509854, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Mon Oct 12 00:05:00 CST 2015, time=2015-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570733, encodeId=820615e073320, content=<a href='/topic/show?id=03d55395183' target=_blank style='color:#2F92EE;'>#成像技术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53951, encryptionId=03d55395183, topicName=成像技术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d6b515702368, createdName=photoman, createdTime=Mon Oct 12 00:05:00 CST 2015, time=2015-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38354, encodeId=b53438354ee, content=感谢作者分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Sun Oct 11 17:32:00 CST 2015, time=2015-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38283, encodeId=669d38283f8, content=动态成像发展迅速, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Oct 10 17:49:00 CST 2015, time=2015-10-10, status=1, ipAttribution=)]
    2015-10-11 hlycom3356

    感谢作者分享

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2079105, encodeId=eeea20e910562, content=<a href='/topic/show?id=caa55488ea4' target=_blank style='color:#2F92EE;'>#技术活#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54887, encryptionId=caa55488ea4, topicName=技术活)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=54f9127, createdName=tulenzi, createdTime=Mon Dec 21 06:05:00 CST 2015, time=2015-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375098, encodeId=0b0013e509854, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Mon Oct 12 00:05:00 CST 2015, time=2015-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570733, encodeId=820615e073320, content=<a href='/topic/show?id=03d55395183' target=_blank style='color:#2F92EE;'>#成像技术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53951, encryptionId=03d55395183, topicName=成像技术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d6b515702368, createdName=photoman, createdTime=Mon Oct 12 00:05:00 CST 2015, time=2015-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38354, encodeId=b53438354ee, content=感谢作者分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=157, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=332823945, createdName=hlycom3356, createdTime=Sun Oct 11 17:32:00 CST 2015, time=2015-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=38283, encodeId=669d38283f8, content=动态成像发展迅速, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sat Oct 10 17:49:00 CST 2015, time=2015-10-10, status=1, ipAttribution=)]
    2015-10-10 lovetcm

    动态成像发展迅速

    0

相关资讯

Lancet HIV:蛋白酶抑制剂单药治疗可作为HIV感染的长期管理方法

抗逆转录病毒疗法(ART)的标准护理使用药物组合被认为必不可少的,这样可以尽量减少治疗失败和耐药性事件。蛋白酶抑制剂是有效的,具有高耐药基因屏障,并在联合治疗后达到病毒载量抑制与单一疗法相同的潜在用途。该研究的目的是评估蛋白酶抑制剂单一疗法在长期的临床使用的好处和临床风险:特别是,对耐药性和将来的治疗方案的效果。 在这项务实,平行组,随机,对照,开放性,非劣效性试验,研究人员在英国招募了

AJRCCM:HIV感染者与非感染者肺部微生物菌群或具有相似性

近日,一项发表在国际杂志the American Journal of Respiratory and Critical Care Medicine的研究论文中,来自科罗拉多大学的科学家表示,尽管HIV携带者和非携带者之间口腔微生物明显不同,但其肺部微生物菌群却表现出了一定的相似性。研究者James M. Beck表示,我们对86名未感染HIV的个体、18名正在进行首次治疗的HIV感染者以及38名

Nat Immunol:HIV的致命弱点

波恩大学的研究人员发现细胞在体内如何找到逆转录病毒的遗传物质。免疫缺陷疾病艾滋病的病原体HIV-1病毒也属于这一组。同时,HIV病毒似乎绕过这一重要防御机制。研究人员将研究结果发表在著名的《自然免疫学》杂志上。免疫系统的第一道防线是对病原体的先天免疫。它基于一种专门的传感器蛋白受体,这些受体能检测异质结构,例如细胞壁成分的细菌或病毒的遗传物质。被称为cGAS的细胞分子充当一种遗传物质的传感器。当c

eLife:靶向治疗精液中HIV病毒 绝杀AIDS

                         近日,来自美国宾夕法尼亚大学医学院的研究人员在国际学术期刊eLife发表了一项最新研究进展,他们发现在

mBio:特定类型避孕药会增加HIV感染风险

                                                        &nb

便宜有效的方法对抗HIV和疱疹病毒——女性高效阴道环

女性植入硅酮阴道环可以释放亲水分子如泰诺福韦(艾滋病抗病毒药物)和阿昔洛韦(治疗单纯疱疹病毒药物)。这一举措将有助于有暴露风险的女性避免艾滋病和性传播疾病(STIs)等疾病的感染。 法国圣艾蒂安大学病毒学家、化学家和硅胶工程师等研究人员通过努力,使得这一设想有望变成现实。 使用高分子材料实行控释技术的设想最早出现于20世纪60年代,研究人员已成功使用阴道环设备为女性提供长效类固醇以治疗更年期临床表

Baidu
map
Baidu
map
Baidu
map