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J Periodontal Res: :乳酸杆菌治疗种植体周围疾病的评价

2018-07-25 MedSci MedSci原创

之前有研究表明,口服益生菌似乎可以改善牙周病的治疗效果,但是它们在治疗种植体周围疾病方面的疗效证据有限。本研究的目的是在临床和微生物学上评估口服益生菌乳酸杆菌(Lactobacillus reuteri Prodentis)作为佐剂用于种植体周围粘膜炎或种植体周围炎的治疗,并评估其效果。

之前有研究表明,口服益生菌似乎可以改善牙周病的治疗效果,但是它们在治疗种植体周围疾病方面的疗效证据有限。本研究的目的是在临床和微生物学上评估口服益生菌乳酸杆菌(Lactobacillus reuteri Prodentis)作为佐剂用于种植体周围粘膜炎或种植体周围炎的治疗,并评估其效果。

设计了一项随机,对照,平行设计,三盲前瞻性临床研究。纳入研究的患者部分无牙颌,并且患有种植体周围粘膜炎或种植体周围炎。X射线检测骨吸收≥5mm和/或≥50%种植体长度的种植体被排除在外,每个患者仅包含一个种植体。在非手术机械治疗后,受试者被随机分配,每天服用1片益生菌锭剂或1片安慰剂锭剂,持续30天。在治疗前,治疗后30天和90天时,进行牙周检查(一般菌斑指数和探诊出血)和植入部位(探诊深度,菌斑指数和探诊出血)微生物学检查(以确定聚集性放线杆菌,在进行临床测量的相同研究时间点进行放线菌,Tannerella forsythia,,牙龈卟啉单胞菌,密螺旋体,中间普氏菌,消化链球菌,具核杆菌,直肠弯曲杆菌和Eikenella corrodens)。

结果:共有44名患者,其中22名患有种植体周围粘膜炎,22名患有种植体周围炎,随机接受益生菌或安慰剂治疗。益生菌乳酸杆菌与机械疗法相比,单独使用机械疗法治疗产生了额外的改善,包括粘膜炎患者的一般临床参数(探查出血)和种植体周围粘膜炎的水平(探诊深度)或种植体周围炎(探查出血和探诊深度)。然而,乳酸杆菌对种植体外微生物群的影响非常有限,因为发现唯一显着减少的参数是粘膜炎中牙龈卟啉单胞菌的细菌负荷(P = .031)。

结论:连续给予乳酸杆菌30天结合全口刮治,至少在90天内改善了患有粘膜炎或种植体周围炎的种植体的临床参数,但微生物效应更有限。益生菌为预防和治疗种植体周围疾病提供了另一种治疗方法,但仍需要进一步开展标准化变量的长期前瞻性研究

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    2018-12-09 huangdf
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    2018-10-30 feather89
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    2018-07-27 huagfeg
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    2018-07-26 131****1460

    学习了受益匪浅

    0

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    2018-07-26 飛歌

    学习了很有用

    0

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    2018-07-25 清风拂面

    谢谢分享学习

    0

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