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J Periodontol:唾液神经肽、应激与牙周炎

2018-02-23 MedSci MedSci原创

目前心理压力作为牙周炎风险因素还没有确切的科学证据,主要依据问卷或生物标记研究。本项研究的目的是调查脑源性神经营养因子,P物质,血管活性肠肽(VIP),神经肽Y(NPY),降钙素基因相关肽和肾上腺髓质素以及唾液和血清中的皮质醇,以及牙周健康和疾病与压力的不同方面以及与临床参数可能的关联相结合。

目前心理压力作为牙周炎风险因素还没有确切的科学证据,主要依据问卷或生物标记研究。本项研究的目的是调查脑源性神经营养因子,P物质,血管活性肠肽(VIP),神经肽Y(NPY),降钙素基因相关肽和肾上腺髓质素以及唾液和血清中的皮质醇,以及牙周健康和疾病与压力的不同方面以及与临床参数可能的关联相结合。

实验通过酶联免疫吸附试验和质谱分析法,对56名侵袭性或慢性牙周炎患者和44名健康者进行唾液和血清中神经肽和皮质醇的筛查。通过验证问卷对心理压力进行评估。探讨其与牙周炎,临床参数和压力可能的关系。

结果发现,牙周炎患者VIP和NPY的唾液水平显着高于血清水平。这些神经肽与牙周炎患者的探诊出血的程度,严重性和出血分数相关。女性的唾液VIP水平显着降低。参与者在心理压力方面没有差异。

结论:无论心理压力如何,唾液中的VIP和NPY可能是牙周炎的潜在性别特异性唾液生物标志物。

原始出处:

Hady Haririan, et al. Salivary neuropeptides, stress, and periodontitis. Journal of Periodontology. 2018 January. doi:10.1902/jop.2017.170249

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    2018-10-09 1e145228m78(暂无匿称)

    学习了,谢谢作者分享/

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    2018-11-21 feather89
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