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Heart:心内膜炎幸存者瓣膜反流及随后发生心力衰竭的风险

2019-12-11 xing.T MedSci原创

由此可见,在接受药物治疗的IE幸存者中,严重或中度左侧瓣膜反流患者HF的风险明显高于IE出院时无反流的患者。需要对这些患者进行严密监视以及时进行手术。

原发性瓣膜感染性心内膜炎(IE)幸存者常发生明显的瓣膜反流,但与IE出院后发生心力衰竭(HF)风险之间的相关性很少描述。近日,心脏病领域权威杂志Heart上发表了一篇研究文章,研究人员链接了东丹麦心内膜炎登记中心2002年至2016年的数据,其中包括接受IE药物治疗且存活的患者。

IE出院时通过超声心动图评估左侧瓣膜反流情况,并评估了HF的纵向风险。研究人员采用多变量校正Cox分析法评估了有反流(中度或重度)与没有反流患者发生心力衰竭的相关风险。

研究人员纳入了192例患者,87例出院时存在反流症状(30例主动脉瓣反流和57例二尖瓣反流),105例患者没有反流。IE出院时出现反流的患者在随访5年内HF累积风险为28.7%,而没有反流的患者为12.4%。相应的多变量调整后HR为3.53(95%CI为1.72至7.25)。研究人员发现,与无瓣膜反流的患者相比,主动脉瓣反流(HR=2.91,95%CI为1.14至7.43)和二尖瓣反流(HR=3.95,95%CI为1.80至8.67)患者的心衰风险增加。在随访期间,有或没有反流的患者中分别有21.9%和5.7%的患者接受了左侧瓣膜手术。

由此可见,在接受药物治疗的IE幸存者中,严重或中度左侧瓣膜反流患者HF的风险明显高于IE出院时无反流的患者。需要对这些患者进行严密监视以及时进行手术。 

原始出处:

Lauge Østergaard.et al.Valve regurgitation in patients surviving endocarditis and the subsequent risk of heart failure.heart.2019.http://dx.doi.org/10.1136/heartjnl-2019-315715

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    2019-12-13 zhaojie88
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    2019-12-13 slcumt
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    2019-12-13 feifers
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  7. [GetPortalCommentsPageByObjectIdResponse(id=1708555, encodeId=b8a11e0855566, content=<a href='/topic/show?id=4c2d3051535' target=_blank style='color:#2F92EE;'>#内膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30515, encryptionId=4c2d3051535, topicName=内膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=730431558473, createdName=12498974m61暂无昵称, createdTime=Fri Sep 04 21:06:00 CST 2020, time=2020-09-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350737, encodeId=40701350e3702, content=<a href='/topic/show?id=a32d508e8c3' target=_blank style='color:#2F92EE;'>#心内膜炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50878, encryptionId=a32d508e8c3, topicName=心内膜炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Dec 13 04:06:00 CST 2019, time=2019-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357331, encodeId=b1e5135e331fe, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Dec 13 04:06:00 CST 2019, time=2019-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563184, encodeId=834a1563184ac, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Fri Dec 13 04:06:00 CST 2019, time=2019-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571674, encodeId=126815e1674f3, content=<a href='/topic/show?id=41e33e76137' target=_blank style='color:#2F92EE;'>#反流#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37761, encryptionId=41e33e76137, topicName=反流)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=220d15750403, createdName=feifers, createdTime=Fri Dec 13 04:06:00 CST 2019, time=2019-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1583643, encodeId=9f79158364376, content=<a href='/topic/show?id=508d68e698c' target=_blank style='color:#2F92EE;'>#瓣膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68769, encryptionId=508d68e698c, topicName=瓣膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58dc16986228, createdName=12498e5fm17(暂无昵称), createdTime=Fri Dec 13 04:06:00 CST 2019, time=2019-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=376844, encodeId=d08b3e6844c4, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/05/49dbda1c7803de9dd7c04cdf52fa2202.jpg, createdBy=2d225218913, createdName=拿着枪的小啰啰, createdTime=Wed Dec 11 21:15:13 CST 2019, time=2019-12-11, status=1, ipAttribution=)]
    2019-12-11 拿着枪的小啰啰

    学习了

    0

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