Cell Rep：重磅级发现！抗疟疾神药氯喹或能有效治疗癌症

2017-01-13 佚名生物谷

图片来源：medicalxpress.com 日前，一项发表在国际杂志Cell Reports上的研究报告中，来自肯塔基大学Markey癌症中心的研究人员通过研究发现，一种用于治疗疟疾的药物—氯喹或能够有效治疗转移性癌症患者。在临床试验中，研究者发现，氯喹能够诱导小鼠模型和癌症患者机体中肿瘤抑制蛋白Par-4的分泌，而蛋白Par-4的分泌对于肿瘤细胞死亡以及肿瘤转移的抑制非常关键。

图片来源：medicalxpress.com

日前，一项发表在国际杂志Cell Reports上的研究报告中，来自肯塔基大学Markey癌症中心的研究人员通过研究发现，一种用于治疗疟疾的药物—氯喹或能够有效治疗转移性癌症患者。在临床试验中，研究者发现，氯喹能够诱导小鼠模型和癌症患者机体中肿瘤抑制蛋白Par-4的分泌，而蛋白Par-4的分泌对于肿瘤细胞死亡以及肿瘤转移的抑制非常关键。

研究者表示，氯喹能够通过依赖p53激活的经典分泌通路来诱导Par-4分泌，p53能够直接诱导Rab8b激活，Rab8b是一种GTP酶，其对于Par-4运输到质膜非常重要，本文研究结果表明，氯喹能够诱导正常细胞分泌p53和Rab8b依赖性的Par-4，从而就能够对转移性肿瘤生长进行Par-4依赖性的抑制。

研究人员Rangnekar说道，由于p53在肿瘤中经常会发生突变，其就会使得肿瘤对疗法产生耐受性，然而本文研究中我们发现，一种FDA批准的名为氯喹的药物就能够激活表达p53的正常细胞，使其分泌Par-4来阻断p53缺失的肿瘤进行转移。

目前研究人员正在进行一项临床试验，即利用氯喹来诱导蛋白Par-4分泌从而治疗多种类型癌症患者，研究人员计划进行第二项临床试验，给予癌症缓解的患者持续剂量的氯喹来观察这种药物是否能够有效抑制患者疾病复发。

原始出处

Ravshan Burikhanov9, Nikhil Hebbar9, Sunil K. Noothi, Nidhi Shukla, James Sledziona, Nathália Araujo, Meghana Kudrimoti, Qing Jun Wang, David S. Watt, Danny R. Welch, Jodi Maranchie, Akihiro Harada, Vivek M. Rangnekar10.Chloroquine-Inducible Par-4 Secretion Is Essential for Tumor Cell Apoptosis and Inhibition of Metastasis.Cell Rep.2016

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#插入话题

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2017-04-10 维他命

#CEL#

55 0
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2017-07-25 zhangying8800

#抗疟疾#

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2017-12-06 zhaozhouchifen

#Cell#

108 0
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2017-01-15 xxxx1054

#重磅#

78 0
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2017-01-15 docwu2019

#有效治疗#

63 0
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2017-01-13 yafeiliutjh

老药新用

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