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Gastroenterology:长期服用诺氟沙星治疗晚期肝硬化的疗效观察

2018-12-09 MedSci MedSci原创

关于长期口服氟喹诺酮治疗晚期肝硬化患者的疗效一直存在很多争议,因此,研究人员进行了一项随机对照试验,以评估氟喹诺酮诺氟沙星长期治疗对肝硬化患者生存的影响。

背景与目的
关于长期口服氟喹诺酮治疗晚期肝硬化患者的疗效一直存在很多争议,因此,研究人员进行了一项随机对照试验,以评估氟喹诺酮诺氟沙星长期治疗对肝硬化患者生存的影响。

方法
研究人员对291名Child-Pugh C级肝硬化患者进行了随机双盲试验。所有患者被随机分配到每天一次给予400 mg诺氟沙星(n = 144)或安慰剂(n = 147)进行6个月试验。在前6个月以及之后的9个月和12个月对患者进行身体评估。主要观察结果是通过Kaplan-Meier方法估计6个月的死亡率,并检查自发性细菌性腹膜炎,肝移植的事件或随访期间的失访。

结果
本项研究显示接受诺氟沙星治疗的患者6个月死亡率为14.8%,接受安慰剂治疗的患者为19.7%(P= .21)。在考虑肝移植的竞争风险分析中,诺氟沙星组6个月的累积死亡率显着低于安慰剂组(HR,0.59; 95%CI,0.35-0.99)。诺氟沙星与安慰剂相比,6个月死亡的亚分布危险比为腹水蛋白浓度<15 g / L和1.39(95%CI,0.42-4.57)的患者为0.35(95%CI,0.13-0.93)。诺氟沙星显着降低革兰氏阴性细菌感染的发生率,而不会增加由艰难梭菌或多重耐药细菌引起的感染

结论
在这项氟喹诺酮治疗的晚期肝硬化患者的随机对照试验显示,诺氟沙星没有降低肝硬化患者6个月的死亡率,然而,诺氟沙星似乎可以增加腹水蛋白浓度低的患者的生存率。

原始出处:

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    2019-10-31 许安
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  6. [GetPortalCommentsPageByObjectIdResponse(id=1711750, encodeId=c2fd1e11750fc, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sun Jun 30 01:24:00 CST 2019, time=2019-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2064569, encodeId=6c02206456911, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Thu Sep 26 12:24:00 CST 2019, time=2019-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2072393, encodeId=850520e239309, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Thu Oct 31 18:24:00 CST 2019, time=2019-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504546, encodeId=57c215045461b, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Tue Dec 11 12:24:00 CST 2018, time=2018-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1604561, encodeId=cb551604561a6, content=<a href='/topic/show?id=2a959193334' target=_blank style='color:#2F92EE;'>#诺氟沙星#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91933, encryptionId=2a959193334, topicName=诺氟沙星)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f75719226432, createdName=wsusan1972, createdTime=Tue Dec 11 12:24:00 CST 2018, time=2018-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031997, encodeId=a59c103199e10, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Mon Dec 10 00:24:00 CST 2018, time=2018-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046359, encodeId=c2cc1046359f3, content=谢谢!最新的信息读起来就是收获大, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Mon Dec 10 00:24:00 CST 2018, time=2018-12-10, status=1, ipAttribution=)]
    2018-12-10 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1711750, encodeId=c2fd1e11750fc, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sun Jun 30 01:24:00 CST 2019, time=2019-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2064569, encodeId=6c02206456911, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Thu Sep 26 12:24:00 CST 2019, time=2019-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2072393, encodeId=850520e239309, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Thu Oct 31 18:24:00 CST 2019, time=2019-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504546, encodeId=57c215045461b, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Tue Dec 11 12:24:00 CST 2018, time=2018-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1604561, encodeId=cb551604561a6, content=<a href='/topic/show?id=2a959193334' target=_blank style='color:#2F92EE;'>#诺氟沙星#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91933, encryptionId=2a959193334, topicName=诺氟沙星)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f75719226432, createdName=wsusan1972, createdTime=Tue Dec 11 12:24:00 CST 2018, time=2018-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031997, encodeId=a59c103199e10, content=谢谢梅斯提供这么好的信息,学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=内科新手, createdTime=Mon Dec 10 00:24:00 CST 2018, time=2018-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046359, encodeId=c2cc1046359f3, content=谢谢!最新的信息读起来就是收获大, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Mon Dec 10 00:24:00 CST 2018, time=2018-12-10, status=1, ipAttribution=)]
    2018-12-10 guging

    谢谢!最新的信息读起来就是收获大

    0

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