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Ann Neurol:电阻抗肌动描记法用于杜氏肌营养不良症评价

2017-06-24 zhangfan MedSci原创

电阻抗肌动描记法是有效的杜氏肌营养不良症检测和糖皮质激素治疗效果评价的方法

目前杜氏肌营养不良症(DMD)临床评估和治疗需要敏感、客观和简易评价方法。近日研究人员就电阻抗肌动法(EIM)在DMD评估和治疗中的应用进行了考察。

研究招募了36名DMD男童以及29名健康对照儿童进行多次的EIM测试,研究持续2年对6个方面肌肉功能评估,其中7名患儿使用激素治疗。采用线性混合效应模型与随机截距和斜率评估EIM与肌肉功能测试的结果。

对于7岁以上男童,其6个月和2年的上肢EIM相斜率轨迹存在显著差异,6个月时为-0.074/月,p=0.023,95%,CI,-0.013-0.14;2年时为-0.048/月,p<0.0001,95%,CI-0.028-0.068。对于7岁以下男童,差异存在于6个月时腓肠肌结果(EIM相斜率为0.83°/kHz/mo, =0.007, 95% CI,0.26-1.40)。EIM测试结果异常显著早于功能测试。使用糖皮质激素显著提高EIM相率(0.057/mo,p=0.00019,95% CI=0.028-0.086)以及斜率 (0.14°/kHz/mo, p=0.013, 95% CI=0.028- 0.25), 与糖皮质激素的临床收益相一致。

研究表明电阻抗肌动描记法是有效的杜氏肌营养不良症检测和糖皮质激素治疗效果评价的方法。

原始出处:


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    2017-09-30 yinhl1978
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    2017-06-30 虈亣靌

    小编最牛!啥都知道

    0

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    2017-06-26 虈亣靌

    值得推荐一下

    0

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    2017-06-26 huagfeg
  7. [GetPortalCommentsPageByObjectIdResponse(id=1737043, encodeId=2bbb1e370438e, content=<a href='/topic/show?id=6ee1810e0ad' target=_blank style='color:#2F92EE;'>#肌营养不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81070, encryptionId=6ee1810e0ad, topicName=肌营养不良)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd6034244098, createdName=751943081_32627960, createdTime=Mon Jul 10 09:06:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999999, encodeId=f2c319999997e, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sat Sep 30 11:06:00 CST 2017, time=2017-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2007045, encodeId=a5a2200e04562, content=<a href='/topic/show?id=21fe810e29d' target=_blank style='color:#2F92EE;'>#肌营养不良症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81072, encryptionId=21fe810e29d, topicName=肌营养不良症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7482500171, createdName=ms4468361851264128, createdTime=Thu Mar 29 15:06:00 CST 2018, time=2018-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217172, encodeId=1d3d21e17209, content=小编最牛!啥都知道, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Jun 30 20:34:23 CST 2017, time=2017-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=215578, encodeId=27572155e8a0, content=值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon Jun 26 10:44:23 CST 2017, time=2017-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1444226, encodeId=c58314442263e, content=<a href='/topic/show?id=3d9291459d1' target=_blank style='color:#2F92EE;'>#评价#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91459, encryptionId=3d9291459d1, topicName=评价)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1fee5134542, createdName=huagfeg, createdTime=Mon Jun 26 01:06:00 CST 2017, time=2017-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=215310, encodeId=43f8215310d9, content=学习了很好的内容, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJiaCBO9f33YY0a9cL4rhSH23PNEOVia2szWTbUl6IgFnukCuC2ptOD5mAC0Ax8qGt2pjwudkREHlmA/132, createdBy=d39e1630897, createdName=1dd8aa01m06(暂无匿称), createdTime=Sun Jun 25 17:02:11 CST 2017, time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214796, encodeId=c3de214e96d7, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Sat Jun 24 12:19:24 CST 2017, time=2017-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214753, encodeId=463d214e5380, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sat Jun 24 10:51:00 CST 2017, time=2017-06-24, status=1, ipAttribution=)]
    2017-06-25 1dd8aa01m06(暂无匿称)

    学习了很好的内容

    0

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    2017-06-24 dhzzm

    学习了分享了

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1737043, encodeId=2bbb1e370438e, content=<a href='/topic/show?id=6ee1810e0ad' target=_blank style='color:#2F92EE;'>#肌营养不良#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81070, encryptionId=6ee1810e0ad, topicName=肌营养不良)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd6034244098, createdName=751943081_32627960, createdTime=Mon Jul 10 09:06:00 CST 2017, time=2017-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1999999, encodeId=f2c319999997e, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Sat Sep 30 11:06:00 CST 2017, time=2017-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2007045, encodeId=a5a2200e04562, content=<a href='/topic/show?id=21fe810e29d' target=_blank style='color:#2F92EE;'>#肌营养不良症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81072, encryptionId=21fe810e29d, topicName=肌营养不良症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f7482500171, createdName=ms4468361851264128, createdTime=Thu Mar 29 15:06:00 CST 2018, time=2018-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=217172, encodeId=1d3d21e17209, content=小编最牛!啥都知道, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Jun 30 20:34:23 CST 2017, time=2017-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=215578, encodeId=27572155e8a0, content=值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon Jun 26 10:44:23 CST 2017, time=2017-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1444226, encodeId=c58314442263e, content=<a href='/topic/show?id=3d9291459d1' target=_blank style='color:#2F92EE;'>#评价#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91459, encryptionId=3d9291459d1, topicName=评价)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1fee5134542, createdName=huagfeg, createdTime=Mon Jun 26 01:06:00 CST 2017, time=2017-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=215310, encodeId=43f8215310d9, content=学习了很好的内容, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJiaCBO9f33YY0a9cL4rhSH23PNEOVia2szWTbUl6IgFnukCuC2ptOD5mAC0Ax8qGt2pjwudkREHlmA/132, createdBy=d39e1630897, createdName=1dd8aa01m06(暂无匿称), createdTime=Sun Jun 25 17:02:11 CST 2017, time=2017-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214796, encodeId=c3de214e96d7, content=学习了分享了, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=387d1660055, createdName=dhzzm, createdTime=Sat Jun 24 12:19:24 CST 2017, time=2017-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214753, encodeId=463d214e5380, content=学习了新知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Sat Jun 24 10:51:00 CST 2017, time=2017-06-24, status=1, ipAttribution=)]
    2017-06-24 Y—xianghai

    学习了新知识

    0

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