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JAHA:心血管健康指标及其变化与心血管疾病终生风险的关系

2021-11-13 MedSci原创 MedSci原创

较多数量的CVH指标与较低的终生心血管疾病风险相关。CVH状态的改善可以降低CVD的终生风险并延长无CVD的生命年龄。

尽管血管疾病(CVD)患者的结局在过去几十年中得到了显著改善,但CVD仍然是全球发病率和死亡率的最大单一因素。中国的CVD死亡人数最多,远高于其他何国家。心血管健康(CVH)状态与心血管疾病(CVD)相关。然而,关于CVH变化与CVD风险之间存在的相关性证据很少。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员采用七个指标(吸烟状况、体重指数、身体活动、饮食、总胆固醇、血压和空腹血糖)评估了CVH的状态。

受试者具有0到2、3到4和5到7个理想的心血管指标分别被分类为低、中和高CVH状态。研究人员还评估了受试者2006-2007年期间至2010-2011年期间CVH状态的变化情况。研究人员使用改良的Kaplan-Meier方法计算了CVD的终生风险,并通过多态生命表方法评估了预期寿命。

该研究的分析纳入了82349名参与者。在35岁时,随着理想CVH指标数量的减少,年龄调整后的CVD发病率和终生风险增加。CVH状态的变化方向始终与年龄调整后的CVD发病率和终生风险相关。在35岁时,与CVH状态持续低水平相比(44.6%[95%CI为40.8%–48.5%]),从CVH状态低水平到中等水平(37.6%[95%CI为32.8%–42.4%])或高水平状态(24.4%[95%CI为12.7%–36.0%])改善具有较低的终生风险CVD。CVH的改善可以延长无CVD的寿命。CVH状态变化的发生率和终生风险模式在45岁和55岁时相似。

由此可见,较多数量的CVH指标与较低的终生心血管疾病风险相关。CVH状态的改善可以降低CVD的终生风险并延长无CVD的生命年龄。

原始出处:

Lulin Wang,et al.Ideal Cardiovascular Health Metric and Its Change With Lifetime Risk of Cardiovascular Diseases: A Prospective Cohort Study.JAHA.2021.https://www.ahajournals.org/doi/10.1161/JAHA.121.022502

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    2021-11-15 zhaohui6731
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    2021-11-13 之昂张

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