Sci Rep：外泌体miRNAs的变化或可预测1型糖尿病的发生

2017-08-06 MedSci MedSci原创

1型糖尿病（T1DM）是自身免疫攻击胰岛素产生ß细胞而导致的慢性高血糖的结果。外泌体是来自细胞的膜状脂质囊泡，富含特异性miRNA，或可为某特定疾病的诊断提供信息。为了评估从外泌体中提取的miRNAs作为T1DM诊断的生物标志物的价值。研究人员利用差速离心分离出血浆中的外泌体，并通过纳米粒子跟踪分析和透射电子显微镜观察证实外泌体的存在。提取出外泌体内的总RNA，然后比较了12个T1DM患者和12个

1型糖尿病（T1DM）是自身免疫攻击胰岛素产生ß细胞而导致的慢性高血糖的结果。外泌体是来自细胞的膜状脂质囊泡，富含特异性miRNA，或可为某特定疾病的诊断提供信息。

为了评估从外泌体中提取的miRNAs作为T1DM诊断的生物标志物的价值。研究人员利用差速离心分离出血浆中的外泌体，并通过纳米粒子跟踪分析和透射电子显微镜观察证实外泌体的存在。提取出外泌体内的总RNA，然后比较了12个T1DM患者和12个对照者miRNA的区别。

结果显示，T1DM患者外泌体中7种miRNA的表达与对照组不同（1个上调，6个下调）。然后通过qRT-PCRFenix在24名T1DM和24名对照者的中进行了验证。结果显示大部分下调的miRNAs参与了T1DM的发生。

总之，该研究结果表明，外泌体miRNAs具有诊断T1DM的潜力，并对T1DM发生的分子机制提供了新的见解。

原始出处：

Marta Garcia-Contreras, Sanket H. Shah, et al., Plasma-derived exosome characterization reveals a distinct microRNA signature in long duration Type 1 diabetes. Sci Rep. 2017; 7: 5998. Published online 2017 Jul 20. doi: 10.1038/s41598-017-05787-y.

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2017-12-08 smallant2002

#miR#

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2018-07-10 dzx0922889

#RNAs#

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2017-08-08 Homburg

#miRNA#

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2017-08-08 30397609

#miRNAs#

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2017-08-07 清风拂面

谢谢分享，学习了

108 0
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2017-08-06 wxl882001

学习一下

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