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Neurology:妊娠高血压疾病与认知障碍

2020-12-31 MedSci原创 MedSci原创

妊娠15年后,HDP病史与较差的工作记忆和言语学习独立相关。该关联主要由GH女性所介导。临床医生和经历过HDP的妇女应意识到这种风险。

近日,神经病学领域权威杂志Neurology上发表了一篇研究文章,该研究旨在明确妊娠期高血压疾病(HDP)与妊娠15年后认知障碍之间的关联,研究人员测量了115名具有HDP病史的女性和481名血压正常女性的认知能力。

该研究是一项嵌套队列研究,妊娠后十五年(平均为14.7年,90%范围为[13.9至16.1])通过认知测试评估认知功能。研究人员在不同的认知领域中测量了受试者认知表现:执行功能、处理速度、语言记忆、运动功能和视觉空间能力。整体认知因子(g因子)来自主成分分析。

在HDP的妇女中,妊娠高血压(GH)孕妇为80例(69.6%),先兆子痫的孕妇有35例(30.4%)。患有HDP的女性的g因子低于血压正常的妊娠女性(平均差异为-0.22,90%范围为[-2.06; 1.29])。HDP与15个单词的学习测试结果呈负相关:即时回忆(-0.25,95%CI为[-0.44至-0.06])和延迟回忆(-0.30,95%CI为-0.50至-0.10)。GH女性在15个单词的学习测试中的表现要比血压正常的妊娠女性差很多。

由此可见,妊娠15年后,HDP病史与较差的工作记忆和言语学习独立相关。该关联主要由GH女性所介导。临床医生和经历过HDP的妇女应意识到这种风险。

原始出处:

Maria C ADANK.et al.Hypertensive disorders of pregnancy and cognitive impairment: A prospective cohort study.Neurology.2020.https://doi.org/10.1212/WNL.0000000000011363

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    2022-02-01 ms8000002131411968

    涨知识了

    0

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    2021-05-06 MedSciZeng

    #Neurology#点击进入话题查看更多相关文章 或评论时插入话题加入讨论

    0

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    2021-05-10 yinhl1978
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    2021-01-07 zhouqu_8

    妊娠期高血压会造成以后的工作记忆下降和言语学习能力下降,#妊娠期高血压#

    0

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    2020-12-31 IVF密密

    妊娠高血压这一类妊娠疾病,需要加强关注,甚至包括妊娠心肌病

    0

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    2020-12-31 jyzxjiangqin

    好文章!

    0

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