CLIN CHEM：胃癌无创检测的唾液细胞外RNA生物标记物的发现和验证

2018-10-30 MedSci MedSci原创

对胃癌无创早期检测需要有效的生物标志物。在此，研究人员研究了唾液细胞外RNA (exRNA)作为胃癌临床评估工具的生物标记物。在韩国三星医疗中心对294例(163例胃癌患者和131例非胃癌患者)进行内镜检查，采集未刺激的唾液标本。对63例胃癌和31例非胃癌患者的唾液转录组进行了分析，并通过逆转录定量实时PCR (RT-qPCR)验证了mRNA生物标志物候选。同时，对10例胃癌和10例非胃癌

对胃癌无创早期检测需要有效的生物标志物。在此，研究人员研究了唾液细胞外RNA (exRNA)作为胃癌临床评估工具的生物标记物。

在韩国三星医疗中心对294例(163例胃癌患者和131例非胃癌患者)进行内镜检查，采集未刺激的唾液标本。对63例胃癌和31例非胃癌患者的唾液转录组进行了分析，并通过逆转录定量实时PCR (RT-qPCR)验证了mRNA生物标志物候选。同时，对10例胃癌和10例非胃癌患者的唾液样本进行了microRNA (miRNA)生物标志物的分析和验证。候选生物标志物通过RT-qPCR在100/100份胃癌和非胃癌患者唾液样本的独立队列中进行验证。对经过验证的单个标记进行最优面板设计。

研究结果鉴定了30个mRNA和15个miRNA候选基因，它们的表达模式与GC的存在有关。其中，12条mRNA和6条miRNA候选基因通过RT-qPCR的发现队列进行验证，并通过独立队列(n = 200)进一步验证。配置的biomarker panel由3个mRNA (SPINK7, PPL, SEMA4B)和2个miRNA (MIR140-5p, MIR301a)组成，在GC组中都出现显著下调，在ROC曲线(AUC)下的面积为0.81 (95% CI, 0.72 0.89)。结合人口因素，生物标志物小组的AUC达到0.87 (95% CI, 0.80 0.93)。

本研究已经发现并验证了一组唾液外显RNA生物标记物，其临床性能可靠，可用于胃癌的检测。研究表明唾液外显RNA生物标志物在GC筛选和风险评估中具有的潜在效用。

原始出处：

Feng Li, Janice M. Yoshizawa, Kyoung-Mee Kim, Discovery and Validation of Salivary Extracellular RNA Biomarkers for Noninvasive Detection of Gastric Cancer

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2019-08-16 医者仁心

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2018-11-01 hbwxf

#生物标记物#

74 0
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2018-11-01 zhangpaul93

#无创检测#

89 0
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2018-11-01 zhangpaul93

#无创检测#

89 0
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2018-11-01 1209e435m98(暂无昵称)

学习了，谢谢分享

96 0

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