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JAHA:心力衰竭患者的家族性死亡风险

2018-12-16 xing.T MedSci原创

由此可见,该研究结果表明与HF特定相关的不良生存家族史是HF患者死亡的重要危险因素。需要进一步的研究来归纳这些患者的分子基础和详细的临床表型特征。

家族因素对心力衰竭(HF)患者预后的影响尚不清楚。近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,这项全国性的随访研究旨在明确因HF住院治疗的兄弟姐妹发生HF的家族性死亡风险。

研究人员将几个瑞典全国性登记中心中0至80岁的个人数据进行链接。研究人群为2000年至2012年期间373例首次住院治疗的HF患者,兄弟姐妹中1名先证者曾在2000年至2007年间首次因HF住院治疗。排除了患有先天性心脏病的家庭。首次因HF住院治疗后死亡率的家庭风险比(HRs)通过Cox回归来确定。先证者存活的影响被分类为短期存活(<5年)或长期存活(≥5年),并且在先证者存活的最初5年中连续进行确认。

研究人员对年龄、性别、时间段和常见HF合并症进行了调整。先证者短期存活与总体死亡率相关,其HR为2.02(95%置信区间为1.32-3.09)。在既往没有冠心病的患者中,该HR为2.35(95%可信区间为1.18-4.67),而缺血性HF患者的HR为1.84(95%置信区间为1.05-3.23)。对于先证者每多活一年,死亡风险均有所降低,HR为0.86(95%置信区间为0.77-0.98)。

由此可见,该研究结果表明与HF特定相关的不良生存家族史是HF患者死亡的重要危险因素。需要进一步的研究来归纳这些患者的分子基础和详细的临床表型特征。

原始出处:

Magnus P. Lindgren.et al.Familial Mortality Risks in Patients With Heart Failure—A Swedish Sibling Study.JAHA.2018.https://www.ahajournals.org/doi/full/10.1161/JAHA.118.010181

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    2018-12-18 topnew

    学习学习谢谢

    0

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    2018-12-18 zhaohui6731
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    2018-12-16 ylzr123

    好文,值得点赞!认真学习,应用于实践!谢谢分享给广大同好!

    0

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    2018-12-16 1248f5dcm06(暂无昵称)

    学习

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