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Sci Rep:老年人前列腺癌的根治性放射治疗相关研究

2017-10-28 AlexYang MedSci原创

是否年龄能够预测前列腺癌治疗的结果仍旧具有争议。随着全球人口的老龄化,对年龄能够产生的影响的理解也许能够促使人们更好的确定决策的选择以及更好的理解前列腺的自然史。最近,有研究人员对患有局部前列腺恶性腺瘤且接受过根治性放射治疗(RT)(76-78Gy)的581名病人进行了回顾性的分析,时间为2004年到2015年年间,地点在台湾地区的医疗中心。受试者的平均年龄为78岁。跟踪调查的平均时间为66个月。

是否年龄能够预测前列腺癌治疗的结果仍旧具有争议。随着全球人口的老龄化,对年龄能够产生的影响的理解也许能够促使人们更好的确定决策的选择以及更好的理解前列腺的自然史。

最近,有研究人员对患有局部前列腺恶性腺瘤且接受过根治性放射治疗(RT)(76-78Gy)的581名病人进行了回顾性的分析,时间为2004年到2015年年间,地点在台湾地区的医疗中心。受试者的平均年龄为78岁。跟踪调查的平均时间为66个月。研究人员对所有参与的受试者分析发现,5年生化失败自由生存(BFFS)、远距离转移自由生存(DMFS)、疾病特异性生存(DSS)和总生存(OS)率分别为84.9%、93.8%、97.8%和86.6%。研究人员比较80岁以上和以下受试者发现,5年BFFS、DMFS或者DSS并没有差异。多变量Cox回归分析表明在RT之前,肿瘤阶段、格林森得分、初始PSA和潜伏期为BFFS的显著风险因子。另外,RT之前的潜伏期在80岁以上组别中要比80岁以下组别显著更长。在其他研究中,进行RT时间的推迟也许能够解释之前所发现的在老年人患者中劣质的疾病控制。最后,研究人员指出,除了OS,并没有发现老年患者中的治疗结果或者毒性的差异。

原始出处:

Yuan-Hung Wu, Wan-Chin Yang, Yu-Wen Hu et al. Definitive Radiotherapy for Older Patients with Prostate Cancer: Experience of a Medical Center in Taiwan. Sci Rep. 24 Oct 2017.

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    2017-10-30 jeanqiuqiu
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    2017-10-29 Y—xianghai

    学习了新知识

    0

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    2017-10-28 wxl882001

    学习一下

    0

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    2017-10-28 清风拂面

    很好的文章.谢谢分享.

    0

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    2017-10-28 183****7028

    学习

    0

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