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J Allergy Clin Immun:湿疹病因新说:是由于皮肤缺乏微丝蛋白

2017-05-07 tulip1999 来宝网

一项最新研究首次揭示了,缺乏关键屏障蛋白微丝蛋白可能导致皮肤蛋白发生改变使人易患湿疹的独立因素。

一项最新研究首次揭示了,缺乏关键屏障蛋白微丝蛋白可能导致皮肤蛋白发生改变使人易患湿疹的独立因素。

来自英国纽卡斯尔大学及葛兰素史克公司下属Stiefel公司的研究人员在《过敏与临床免疫学杂志》发表了他们的最新研究成果。

首席研究员,来自纽卡斯尔大学皮肤病学教授,同时也是纽卡斯尔皇家维多利亚医院皮肤病学及湿疹病专家Nick Reynolds说道,他们的发现“证实了微丝蛋白缺乏导致皮肤屏障功能出现问题从而诱发湿疹的重要性。”

同时,他和他的同事还认为,这项研究可能会导致针对湿疹根本病因的药物出现,而不仅仅是减轻症状。

湿疹通常是以皮肤干燥、瘙痒、皲裂、粗糙为特征的一种疾病,主要累及手、脚、脸以及腘窝和肘部。

湿疹还会出现水泡,挠抓时会有液体流出。这种状况会导致睡眠不安,严重者甚至会影响到生活质量。

最常见的一类湿疹是一种被称为特应性皮炎的炎症性、非传染性皮肤病。在美国,大约有30%的人患有这种疾病,其中大多数是儿童和青少年。

本文中,湿疹这个词特指特应性皮炎。

湿疹的确切病因不明。然而,研究表明,它很可能是由遗传和环境因素相互作用的结果,可能与皮肤屏障功能障碍及免疫系统功能障碍有关。患有湿疹的人也可能患上哮喘和花粉症。

在他们的研究报告中,研究人员解释道,微丝蛋白在维持皮肤屏障功能方面起着重要的作用,之前的研究已经证实,缺乏微丝蛋白很容易诱发湿疹。

“此类研究使得科学家能够开发出针对湿疹病因治疗的药物,而不仅仅是改善其症状。鉴于湿疹引发的种种不适,这是一个极为关键的研究课题。”英国皮肤科医师协会的Nina Goad如是说。

原始出处:

Martina S. Elias, et al. Proteomic analysis of filaggrin deficiency identifies molecular signatures characteristic of atopic eczema. The Journal of Allergy and Clinical Immunology.Published online: May 04, 2017

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    2017-05-10 尹玉伟

    学习了……厉害厉害

    0

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    2017-05-08 膀胱癌
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content=微丝蛋白。, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/5s91rMfm6qvY69RmicgQoiadpG5Djkdl1h3QrsGylJnQHFNiaQz1HvqgV2QCQD6kVnb15swwZFYjZhVWmOv3AOQrQ/132, createdBy=6c5c2055186, createdName=七堇, createdTime=Sun May 07 06:41:54 CST 2017, time=2017-05-07, status=1, ipAttribution=)]
    2017-05-08 186****0580(小山羊)

    学习了谢谢了。

    0

  4. 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content=微丝蛋白。, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/5s91rMfm6qvY69RmicgQoiadpG5Djkdl1h3QrsGylJnQHFNiaQz1HvqgV2QCQD6kVnb15swwZFYjZhVWmOv3AOQrQ/132, createdBy=6c5c2055186, createdName=七堇, createdTime=Sun May 07 06:41:54 CST 2017, time=2017-05-07, status=1, ipAttribution=)]
    2017-05-07 王秀

    很好,又学到了新的知识

    0

  5. 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content=微丝蛋白。, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/5s91rMfm6qvY69RmicgQoiadpG5Djkdl1h3QrsGylJnQHFNiaQz1HvqgV2QCQD6kVnb15swwZFYjZhVWmOv3AOQrQ/132, createdBy=6c5c2055186, createdName=七堇, createdTime=Sun May 07 06:41:54 CST 2017, time=2017-05-07, status=1, ipAttribution=)]
    2017-05-07 医张生

    微丝蛋白缺乏只有改变基因。

    0

  6. 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content=微丝蛋白。, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/5s91rMfm6qvY69RmicgQoiadpG5Djkdl1h3QrsGylJnQHFNiaQz1HvqgV2QCQD6kVnb15swwZFYjZhVWmOv3AOQrQ/132, createdBy=6c5c2055186, createdName=七堇, createdTime=Sun May 07 06:41:54 CST 2017, time=2017-05-07, status=1, ipAttribution=)]
    2017-05-07 医艺依意

    学习了,谢谢分享

    0

  7. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Sun May 07 13:58:14 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194992, encodeId=100819499258, content=微丝蛋白缺乏只有改变基因。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=01bb1684217, createdName=医张生, createdTime=Sun May 07 11:58:16 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194867, encodeId=4e8c19486e8f, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, 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likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Sun May 07 06:56:47 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194819, encodeId=fc0c1948196c, content=学习了,很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun May 07 06:45:26 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194815, encodeId=55331948157c, content=微丝蛋白。, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/5s91rMfm6qvY69RmicgQoiadpG5Djkdl1h3QrsGylJnQHFNiaQz1HvqgV2QCQD6kVnb15swwZFYjZhVWmOv3AOQrQ/132, createdBy=6c5c2055186, createdName=七堇, createdTime=Sun May 07 06:41:54 CST 2017, time=2017-05-07, status=1, ipAttribution=)]
    2017-05-07 执着追梦

    学习,感谢分享!

    0

  8. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Sun May 07 13:58:14 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194992, encodeId=100819499258, content=微丝蛋白缺乏只有改变基因。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=01bb1684217, createdName=医张生, createdTime=Sun May 07 11:58:16 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194867, encodeId=4e8c19486e8f, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, 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likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Sun May 07 06:56:47 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194819, encodeId=fc0c1948196c, content=学习了,很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun May 07 06:45:26 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194815, encodeId=55331948157c, content=微丝蛋白。, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/5s91rMfm6qvY69RmicgQoiadpG5Djkdl1h3QrsGylJnQHFNiaQz1HvqgV2QCQD6kVnb15swwZFYjZhVWmOv3AOQrQ/132, createdBy=6c5c2055186, createdName=七堇, createdTime=Sun May 07 06:41:54 CST 2017, time=2017-05-07, status=1, ipAttribution=)]
    2017-05-07 三生有幸9135

    学习一下谢谢分享

    0

  9. 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likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Sun May 07 06:56:47 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194819, encodeId=fc0c1948196c, content=学习了,很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun May 07 06:45:26 CST 2017, time=2017-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194815, encodeId=55331948157c, content=微丝蛋白。, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/5s91rMfm6qvY69RmicgQoiadpG5Djkdl1h3QrsGylJnQHFNiaQz1HvqgV2QCQD6kVnb15swwZFYjZhVWmOv3AOQrQ/132, createdBy=6c5c2055186, createdName=七堇, createdTime=Sun May 07 06:41:54 CST 2017, time=2017-05-07, status=1, ipAttribution=)]
    2017-05-07 1ddf0692m34(暂无匿称)

    学习了,很好

    0

  10. 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content=微丝蛋白。, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/5s91rMfm6qvY69RmicgQoiadpG5Djkdl1h3QrsGylJnQHFNiaQz1HvqgV2QCQD6kVnb15swwZFYjZhVWmOv3AOQrQ/132, createdBy=6c5c2055186, createdName=七堇, createdTime=Sun May 07 06:41:54 CST 2017, time=2017-05-07, status=1, ipAttribution=)]
    2017-05-07 七堇

    微丝蛋白。

    0

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