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Diabetes Care:妊娠期糖尿病发病趋势严峻

2014-07-09 佚名 dxy

众所周知,女性糖尿病患者妊娠期间各种妊娠并发症发生率显著增加。然而,近年来妊娠期糖尿病发病趋势,以及围产期结局危险因素尚不清楚。 为此,来自加拿大多伦多大学医学院的Denice S. Feig教授及其团队进行了一项研究,探讨近年来妊娠期糖尿病发病趋势,并调查近年来严重围产期结局的危险因素是否有变化。该研究结果发表在2014年06月的Diabetes Care杂志上。 该研究是一项基于人群的队列研究

众所周知,女性糖尿病患者妊娠期间各种妊娠并发症发生率显著增加。然而,近年来妊娠期糖尿病发病趋势,以及围产期结局危险因素尚不清楚。

为此,来自加拿大多伦多大学医学院的Denice S. Feig教授及其团队进行了一项研究,探讨近年来妊娠期糖尿病发病趋势,并调查近年来严重围产期结局的危险因素是否有变化。该研究结果发表在2014年06月的Diabetes Care杂志上。

该研究是一项基于人群的队列研究,共纳入1996年04月01日至2010年03月31日期间在加拿大多伦多市分娩的1109605例产妇。Feig教授等将这些产妇分为三组:妊娠糖尿病(GDM),45384例;糖尿病合并妊娠,13278例;以及非糖尿病,1050943例。利用Poissom回归分析计算妊娠期糖尿病经年龄校正后的年发病率,并比较各组间每年严重围产期结局的发病率。

该研究发现,从1996年至2010年期间,妊娠糖尿病和糖尿病合并妊娠经年龄校正后的发病率都翻了一倍。尽管1996年至2010年期间先天异常发生率下降了23%,但是,围产期死亡率没有显著变化。此外,与非糖尿病产妇相比,糖尿病合并妊娠和妊娠糖尿病产妇所生胎儿先天异常风险显著增加,而且,糖尿病合并妊娠产妇围产期死亡率仍比较高。

该研究提示,在过去14年期间,妊娠糖尿病和糖尿病合并妊娠发病率增加了一般,而且,伴随着妊娠期糖尿病患病率的增加,妊娠期糖尿病的总体社会负担也在增加。尽管糖尿病产妇所生胎儿的先天性异常发生率下降,但是,围产期死亡率没有显著变化,而且,与非糖尿病产妇相比,妊娠糖尿病和糖尿病合并妊娠产妇的围产期死亡率仍明显升高。Feig教授指出,还需要继续努力以降低妊娠糖尿病和糖尿病合并妊娠产妇的各种围产期不良结局。

原始出处:

Feig DS1, Hwee J2, Shah BR3, Booth GL4, Bierman AS5, Lipscombe LL6.Trends in incidence of diabetes in pregnancy and serious perinatal outcomes: a large, population-based study in Ontario, Canada, 1996-2010.Diabetes Care. 2014 Jun;

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    2015-04-11 x35042875

    糖尿病肾病进展风险的关系没有发现。

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    2015-04-02 智智灵药
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