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Metabolism:产妇孕前吸烟与脐带血激素水平之间的相关性分析!

2017-06-25 xing.T MedSci原创

与从不吸烟的母亲相比,早孕期吸烟者分娩的胎儿具有较低脐血IGF-1水平,这可能会引起不良代谢结局。这些研究结果为育龄期妇女的戒烟计划提供了更进一步的证据。

妊娠期间产妇吸烟与胎儿发育不良和后代的心脏代谢健康不良密切相关。然而,这些关联的激素途径尚不清楚。近日,代谢性疾病领域权威杂志Metabolism-Clinical and Experimental上发表了一篇研究文章,研究人员设计了一个大型前瞻性队列研究评估了孕妇吸烟习惯与脐带血激素水平之间的相关性。

在1999-2002年期间从波士顿地区Viva项目的队列中研究人员招募了978对母婴进行了研究。研究人员将母亲分为早孕吸烟者、孕前吸烟者或从不吸烟者,并检测了脐带血中IGF-1、IGF-2、IGFBP-3、瘦素、脂联素、胰岛素和C肽的浓度。研究人员使用调整了母体妊娠前体重指数(BMI)、种族/民族、胎次、教育和婴儿性别的线性回归模型进行分析。研究人员对整个队列和根据婴儿性别分层后进行了分析。

研究人员发现13%的女性是早孕吸烟者,20%是孕前吸烟者,68%的女性是从不吸烟者。早孕吸烟者的婴儿IGF-1水平较低,在调整了IGFBP-3后[-5.2 ng/mL(95%可信区间为-8.6至-1.7)],这种相关性在女孩中更加明显[-10.7 ng/mL(95%可信区间为-18.5至-2.9)vs. 男孩为-4.0ng/mL(95%可信区间为-8.4至0.4)。妊娠早期吸烟与IGF-1以外的其他脐带血激素无关。孕前吸烟者的婴儿脐带血激素类似于从不吸烟者的婴儿。

与从不吸烟的母亲相比,早孕期吸烟者分娩的胎儿具有较低脐血IGF-1水平,这可能会引起不良代谢结局。这些研究结果为育龄期妇女的戒烟计划提供了更进一步的证据。

原始出处:

Abby F. Fleisch,et al. Associations of maternal prenatal smoking with umbilical cord blood hormones: the Project Viva cohort. Metabolism-Clinical and Experimental.2017. http://dx.doi.org/10.1016/j.metabol.2017.04.001

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    2017-07-31 guojianrong
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    2018-06-03 szhvet
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    2017-12-14 一闲
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style='color:#2F92EE;'>#ABO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1762, encryptionId=6c6f1e62c5, topicName=ABO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b6c918580135, createdName=闆锋旦, createdTime=Tue Jun 27 10:22:00 CST 2017, time=2017-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577174, encodeId=c27b15e7174b4, content=<a href='/topic/show?id=d86d1159e36' target=_blank style='color:#2F92EE;'>#Metabolism#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11597, encryptionId=d86d1159e36, topicName=Metabolism)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a6516392333, createdName=1249859em43(暂无昵称), createdTime=Tue Jun 27 10:22:00 CST 2017, time=2017-06-27, status=1, ipAttribution=), 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    2017-07-24 lofter

    学习了,感谢分享

    0

  6. 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  8. 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GetPortalCommentsPageByObjectIdResponse(id=1542384, encodeId=1f551542384d1, content=<a href='/topic/show?id=82c0846654a' target=_blank style='color:#2F92EE;'>#脐带#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84665, encryptionId=82c0846654a, topicName=脐带)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06713409761, createdName=1249859em42(暂无昵称), createdTime=Tue Jun 27 10:22:00 CST 2017, time=2017-06-27, status=1, ipAttribution=)]
    2017-06-27 闆锋旦
  9. 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12月13日中午,湖南省人民医院实施了一例特殊的手术,一名重280斤的孕妇来到医院,因体重严重超标,手术及麻醉难度倍增。于是,在产科医生的紧急讨论与求助下,产科、麻醉科、新生儿科等共16名医务人员共同努力,终于接生成功!感人小细节:医生用嘴吸痰救新生儿。这名280斤的孕妇实施剖宫产手术后,婴儿出现面色略显青紫,不能啼哭,呼吸困难症状。危急时刻,一名医生用嘴将黏稠物不停往外吸,不一会儿,婴儿喉咙里的

产妇抢救无效死亡 医生被打致脊髓受损下半身暂无知觉

6日,一名产妇生命垂危在广水市第一人民医院接受救治,最终抢救无效不幸身亡。患者家属情绪激动堵住产房的门,不准医护人员离开,一名麻醉科男医生在冲突中被打伤。昨日(4月7日),广水警方介入调查此事。受伤的麻醉医生被转到武汉协和医院治疗,情况有所好转。●网传患者家属殴打医生昨日,微信朋友圈一条《惊呆!网爆广水一麻醉师被病人家属打成截瘫》的消息被频频转发。

9小时,11000ml血,这个产妇被救回来了……

产妇因为盆腹腔严重粘连,子宫下段与膀胱致密粘连,手术医生至今记得“自己手术刀划过的地方都‘硬邦邦’的”,且“腹腔内处处在冒血,出血的速度不慢。”集结了8大学科专家,历时9个小时,输血过万,上海交通大学医学院附属新华医院(下称新华医院)才终于把45岁的产妇余萍(化名)从鬼门关上拉回来……故事要从4月份说起。4月5日,孕24周的余萍到新华医院产科门诊,B超提示中央性前置胎盘,盆腔MRI显示中央性前置胎

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