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Pediatrics:接种疫苗后母乳中的新冠抗体升高

2021-08-19 xiangting MedSci原创

通过母乳 (HM) 获得被动和主动免疫是婴儿免疫力发展的关键。一些传染性疾病和疫苗会导致母乳免疫成分的改变。

通过母乳 (HM) 获得被动和主动免疫是婴儿免疫力发展的关键。一些传染性疾病和疫苗会导致母乳免疫成分的改变。这项发表在儿科学顶级期刊Pediatrics上的研究分析了母亲接种新冠疫苗后,母乳中的新冠病毒抗体是否升高。

该研究采用前瞻性队列设计,纳入接种 COVID-19 疫苗时正处于哺乳期的女性,在其接种第二剂疫苗后的第 14 天,收集血液和母乳样本。后续分析了血液和母乳中的核衣壳蛋白IgG 抗体,以及刺突 1 蛋白受体结合域 (RBD) IgM 和IgG 抗体,以及母乳中的新冠病毒IgA、IgM 和 IgG 抗体。

结果发现,94%的参与者接种了 BNT162b2 mRNA 新冠疫苗,6% 接种了mRNA-1273 新冠疫苗。针对新冠病毒刺突蛋白 RBD 的 IgG 抗体平均血清浓度为 3379.6±1639.5 BAU/mL。所有接种疫苗的参与者母乳中都有新冠病毒IgG 抗体,而89% 有 IgA 抗体。母乳喂养≥24 个月的参与者乳汁中的 IgG 和IgA 抗体浓度明显高于母乳喂养<24 个月的参与者(P<.001)。

                                                       母乳中的抗体浓度

由此可见,接种COVID-19 疫苗与母乳中的特定免疫球蛋白有明确关联。这种影响在哺乳超过 23 个月的母亲中更为明显。哺乳对免疫球蛋白的影响是特定的,且与其他因素无关。

 

原始出处:

Dolores Sabina Romero Ramìreza.SARS-CoV-2 Antibodies in Breast Milk After Vaccination. Pediatrics. August  2021.

 

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    2022-02-18 feather89
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    2021-10-19 hbwxf
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    2021-08-21 villahu
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    2021-08-19 公卫新人

    新冠肺炎,疫情何时才能消失

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